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Dr Tamaan K. Osbourne-Roberts reviews the list of patients who probably should not be taking GLP-1 receptor agonists. https://www.medscape.com/viewarticle/glp-1-ras-when-not-prescribe-2024a1000nd8?src=soc_yt -- TRANSCRIPT -- Hi. I'm Tamaan K. Osbourne-Roberts, family medicine physician and lifestyle medicine physician, here to discuss GLP-1 receptor agonist (RA) contraindications — the skinny on when not to prescribe. It can be hard not to think of GLP-1 RAs like Ozempic and Mounjaro as silver bullets, long-awaited miracle drugs that we should probably be putting in the water. And it's true they have the potential to help a lot of people. However, there are definitely groups of patients who should not take these drugs or should take them with caution. They include the following: Patients with a family history of certain cancers. Given that GLP-1 RAs can increase the risk for thyroid cancer, patients with a personal or family history of medullary thyroid cancer or multiple endocrine neoplasia type 2 should not take these drugs. Gut motility issues. Since one of the primary mechanisms of action for these drugs is to slow down the gut, patients with gastroparesis — diabetic or otherwise — or other gut motility issues should avoid these drugs. Patients with inflammatory bowel disease also should not use GLP-1 RAs. Pancreatitis. These medications can increase the risk for serious pancreatitis on their own, so use in patients who have had pancreatitis already is not recommended. Renal impairment. An eGFR [estimated glomerular filtrationrate] below threshold, typically around 30 mL/min/1.73 m2, excludes GLP-1 RAs for some patients. Be certain to check the threshold for individual medications before prescribing. And finally, pregnancy. These drugs generally should not be used in pregnancy, and people of childbearing age with the ability to become pregnant should use contraception while taking these medications. GLP-1 RAs are great medications and have the potential to revolutionize obesity medicine, but like all drugs, it's important to use them safely. Knowing when not to prescribe them is an important step in ensuring patient safety and will help ensure they are available for those who need them. Transcript in its entirety can be found by clicking here: https://www.medscape.com/viewarticle/glp-1-ras-when-not-prescribe-2024a1000nd8?src=soc_yt

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A banana diet, or a banana island, as it is also known is an easy and sweet way to achieve weight loss, help your body cleanse, help you enjoy simplicity and aids your body's healing. The banana plan is very much what it sounds – you eat just bananas for a period of time. I’ve personally done a banana diet myself several times, lasting from 3-12 days and I often get questions from people that ask: “Should I just drink bananas? Can I add milk to my smoothies? Can I drink coffee? Can I add sugar to my smoothies?” The point of a banana island is that all you eat is bananas. In saying that, I would also recommend adding greens (like lettuce, celery, micro greens) and even coconut water to your banana smoothies, at least once a day. FREE WEBINAR: Discover the exact blueprint our clients use to release 10-50 pounds without dieting, get off or reduce their medication and heal their ongoing health issues naturally. Sign up to your FREE masterclass here: www.rawsomehealthy.com/webinar

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Have you ever watched an episode of Shark Tank and been amazed by the innovative products and ideas presented by entrepreneurs? In a recent episode, keto gummies were featured as a potential investment opportunity for the sharks. Keto gummies are a low-carb, high-fat snack that is popular among those following the ketogenic diet. Let’s dive into the key takeaways from this episode and learn more about this new trend in the health and wellness industry.

The Pitch

The entrepreneurs behind the keto gummies presented their product as a tasty and convenient snack for those following a keto lifestyle. They emphasized the benefits of their gummies, which are made with high-quality ingredients and contain no added sugar. The sharks were intrigued by the potential market for this product, as the ketogenic diet continues to gain popularity among health-conscious consumers.

During the pitch, the entrepreneurs shared their vision for growing the keto gummies brand and expanding their product line to include new flavors and variations. They highlighted the unique selling points of their gummies, such as being gluten-free, dairy-free, and keto-friendly. The sharks were impressed by the entrepreneurs’ passion and commitment to creating a product that meets the needs of those following a ketogenic diet.

Investment Offers

As the pitch progressed, the sharks began to consider making investment offers to the entrepreneurs. Each shark shared their thoughts on the potential of the keto gummies business and how they could help the entrepreneurs scale and grow their company. Offers were made based on the valuation of the business and the potential for future growth in the health and wellness market.

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Ultimately, a deal was struck between the entrepreneurs and one of the sharks, who saw the potential for success in the keto gummies industry. The entrepreneurs were thrilled to have the support and expertise of a shark investor to help them navigate the competitive landscape and expand their business. The deal was celebrated as a win-win for both parties, with the potential for long-term growth and success.

Lessons Learned

From this episode of Shark Tank, we can learn valuable lessons about entrepreneurship and innovation in the health and wellness industry. The success of the keto gummies pitch demonstrates the importance of identifying market trends and meeting the needs of a specific target audience. By developing a product that aligns with popular diet trends like keto, entrepreneurs can capitalize on the growing demand for healthy and convenient snack options.

Additionally, the importance of passion and dedication to your product cannot be overstated. The entrepreneurs behind the keto gummies brand were not only knowledgeable about their product but also deeply committed to creating a high-quality snack for those following a ketogenic lifestyle. Their enthusiasm and vision for their business resonated with the sharks and ultimately led to a successful investment deal.

Conclusion

In conclusion, the episode on keto gummies on Shark Tank showcased the potential for success in the health and wellness industry. The entrepreneurs’ pitch and product resonated with the sharks, leading to a successful investment deal that has the potential for long-term growth and success. By staying true to their vision and meeting the needs of consumers following a specific diet trend, the keto gummies brand has positioned itself for success in a competitive market.

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In this video, I explain the three main reasons why people struggle to lose fat, based on my personal experience losing 20kg in 2024. First, I discuss how your body adapts to your current diet, making it necessary to continuously reduce calories to maintain weight loss. I explain the concept of "set point" and why initial progress often leads to plateaus. Second, I address why trying to lose weight through exercise alone is ineffective. Drawing from Herman Pontzer's research, I explain how our bodies maintain constant energy output by reducing BMR when we increase exercise. While exercise is crucial for health, it's not the primary driver of weight loss. Finally, I delve into insulin resistance and its role in fat storage. Based on Dr. Jason Fung's work, I explain how high insulin levels can "lock away" fat stores. I share how fasting helped me break through plateaus by improving insulin sensitivity and making caloric restriction easier. I conclude with my personal journey, where I started with the slow carb diet but found greater success with alternate day fasting. Currently, I eat only three days per week and recently completed a manageable 5-day fast. Beyond weight loss, I've experienced improved mental clarity, focus, and better skin. ⌚️Timestamps: 0:00 Intro 0:13 Your body has adapted to your current diet 1:29 You're trying to exercise to burn body fat 2:57 You're partially insulin resistant 5:09 Personal experience 7:32 Current fasting schedule 8:30 Conclusion 🍿 WATCH NEXT: 1. https://youtu.be/er4LPP8Nnro?si=a1giZJrVR6CO0vQo 2. https://youtu.be/PzPcubTKV5g?si=inN_GtvqqWsEkp7k 3. https://youtu.be/0jlkLfAWRm0?si=jrMj4XYpMTz8-sX5 📚BOOKS MENTIONED: - Burn - Herman Pontzer - The Obesity Code - Dr Fung MY OTHER SOCIALS: 💌 Substack - https://substack.com/@joshpalmer 🐦 Twitter - https://twitter.com/joshpalmer862 📸 Instagram - https://www.instagram.com/joshpalmer862/ 📱  TikTok - https://www.tiktok.com/@jlgpalmer 👨‍💻  Linkedin - https://www.linkedin.com/in/jlgpalmer/ 🎥  Facebook - https://www.facebook.com/JLGPalmer WHO AM I? Hey everyone, my name is Josh and I’m an Investment Actuary-turned-YouTuber. Through my videos here on this channel I share my career experience and also general self-improvement experiments based on my experience. I hope you enjoy!

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