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There are no quick solutions or magical pills that easily solve the problems of obesity. But new anti-obesity drugs are proving remarkably effective, cutting body weight by an average 15% to 22%. Medicines including Ozempic and Wegovy could trigger a shift in how doctors treat obesity. We hear from some people taking them and William Brangham speaks with Dr. Fatima Cody Stanford about the drugs. Stream your PBS favorites with the PBS app: https://to.pbs.org/2Jb8twG Find more from PBS NewsHour at https://www.pbs.org/newshour Subscribe to our YouTube channel: https://bit.ly/2HfsCD6 Follow us: Facebook: http://www.pbs.org/newshour Twitter: http://www.twitter.com/newshour Instagram: http://www.instagram.com/newshour Subscribe: PBS NewsHour podcasts: https://www.pbs.org/newshour/podcasts Newsletters: https://www.pbs.org/newshour/subscribe
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When we eat a meal containing carbohydrates a peptide called GLP-1 is released into the blood and acts in several ways to improve glucose regulation. It stimulates insulin release from the pancreas, increases insulin sensitivity, and suppresses appetite. A peptide called exenatide originally discovered in the venom of the Gila monster activates GLP-1 receptors and is now prescribed as a treatment for diabetes and obesity. Preclinical studies at the NIH showed that exenatide prevents neuronal damage and improves functional outcome in experimental models of Parkinson’s and Alzheimer’s diseases. Professor Tom Foltynie at University College London then led clinical trials of exenatide in Parkinson’s disease which demonstrated beneficial effects of exenatide. In this episode I talk with Professor Foltynie about GLP1 receptor agonists and how they protect neurons against damage and dysfunction in Parkinson’s and other neurological disorders. LINKS Professor Foltynie’s webpage: https://www.ucl.ac.uk/ion/research/our-departments/clinical-and-movement-neurosciences/people/prof-t-foltynie Lancet article: RCT of Exenatide in Parkinson’s disease: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831666/pdf/nihms939356.pdf Review articles on GLP1 and its effects on diabetes and obesity https://www.cell.com/action/showPdf?pii=S1550-4131%2818%2930179-7 Review article on energy metabolism and Parkinson’s disease: https://content.iospress.com/download/journal-of-parkinsons-disease/jpd130335?id=journal-of-parkinsons-disease%2Fjpd130335 Preclinical studies of Exenatide for: Parkinson’s disease: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2633544/pdf/zpq1285.pdf Alzheimer’s disease: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948479/ Huntington’s disease: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628604/pdf/318.pdf
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Do you associate chocolate cake with guilt or celebration? Your answer will have surprising consequences for the success of your diet, says David Robson, author of The Expectation Effect: How Your Mindset Can Transform Your Life. In BBC Reel's latest Rethink episode, he explains how our thoughts can powerfully shape our body’s response to food – and how enjoyment and indulgence are essential ingredients of any healthy diet. Video by Izabela Cardoso & Fernando Teixeira Animation by Maria Adriana Ventura Exectutive Producer: Griesham Taan #bbcreel #bbc #bbcnews
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