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This video explains how obesity is fundamentally a brain-based condition—shaped by neurohormonal signals like leptin, ghrelin, and GLP-1—not just a matter of willpower or lifestyle. Drawing on neuroscience and psychiatry, Dr Sanil Rege breaks down how dysregulation in homeostatic and hedonic systems can drive weight gain, resistance to weight loss, and why most diets fail. You'll also learn how GLP-1 receptor agonists like semaglutide and tirzepatide target brain circuits to support sustainable weight management. ⏱️ Chapter Breakdown: Timestamps 0:00 – Introduction: Why obesity is more than lifestyle 0:54 – The hypothalamic control centre: AgRP vs POMC neurons 1:07 – Leptin resistance and the broken satiety signal 1:49 – The two systems driving Hunger - Homeostatic and Hedonic 3:02 – GLP-1 receptor agonists: how they work on the brain 3:53 – Psychiatric medications and metabolic disruption 🎓 Educational Highlights: – Obesity is regulated by both homeostatic (hypothalamic) and hedonic (reward) systems in the brain – Leptin resistance and ghrelin signalling contribute to persistent hunger – Diets often fail because of neurobiological adaptations that resist sustained weight loss – GLP-1 receptor agonists target brain centres involved in satiety, cravings, and inflammation – Certain psychiatric medications exacerbate metabolic dysfunction—an integrative approach is key – Practical tools for clinicians include layered pharmacological strategies and patient-centred care 👨⚕️ About the Presenter Dr Sanil Rege is a consultant psychiatrist and educator who has trained over 10,000 mental health professionals. Explore advanced psychiatry and neuroscience-based education at The Academy by Psych Scene. #ObesityTreatment #GLP1 #Semaglutide #NeurobiologyOfObesity #WeightLossScience #PsychiatrySimplified #DrRege #PsychSceneAcademy #LeptinResistance #GLP1Agonists #BrainBasedMedicine Related Videos: 👉 What Fasting Does to Your Brain: https://youtu.be/q_5hZUnmsI4 🎓RESOURCES BY PSYCH SCENE: 🌐The Academy by Psych Scene: PSYCHIATRY EDUCATION REDEFINED https://academy.psychscene.com/ Revolutionary psychiatry learning. 🌐Psych Scene Hub: PSYCHIATRY TEXTBOOK OF THE FUTURE https://psychscenehub.com/ The Hub is devoted to making you a better mental health professional. Our team of academic and clinical experts bring you powerful summaries, videos and interviews in psychiatry and neurosciences. 🌐Psych Interview Online: REAL WORLD SKILLS FOR REAL WORLD SUCCESS https://www.psychinterview.com/ The Psych Interview online courses offer high-quality training to help you improve your psychiatric interview skills through self-study. 🌐Psych Scene Online: THE ONLINE COURSES TO HELP YOU SUCCEED https://ranzcpexams.psychscene.com/ Learn at your own pace with the RANZCP Written Exam prep online courses. 🌐Psych Scene: THE PSYCHIATRY TRAINING EXPERTS https://psychscene.com/ Psych Scene offers specialised training and professional development for Psychiatry Trainees, Psychiatrists, General Practitioners and Mental Health Practitioners. -- 📱SOCIALS Subscribe for weekly videos on Psychiatry and Neuroscience: Facebook: https://m.facebook.com/PsychSceneHub Instagram: https://www.instagram.com/psychiatry.excellence/ – 👋 LET’S CONNECT! Follow Sanil Rege on LinkedIn: https://www.linkedin.com/in/sanilrege
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Ginger Lemon Water comes with Great Health Benefits, Helps to lower CHOLESTEROL level, lower BLOOD SUGAR Level, Lose Belly FAT, Lose excess weight, helps improve Liver functions, Boosts your Immunity, Treats Nausea and Vomiting, Improve cognitive functioning, Soothes Pain, Menstrual Cramps, Headaches and improve your General HEALTH. Please, be sure to like, share, leave a comment and SUBSCRIBE if you haven't!. Many Thanks for your SUPPORT. PLEASE, CLICK ON THIS LINK TO SUBSCRIBE...https://www.youtube.com/channel/UCwBy1XdD4s-z9egA04EefEA PLEASE, BE SURE TO CHECK OUT AND WATCH MY OTHER VIDEOS BELOW. HOW TO MAKE COCONUT RICE...https://youtu.be/2WumtElD_os HOW TO MAKE OVEN ROASTED PEANUT...https://youtu.be/X9rgJtiEhy4 HOW TO MAKE HOMEMADE STRAWBERRY JAM...https://youtu.be/be5NXsIi3TI HOW TO MAKE PLANTAIN AND BEANS STEW...https://youtu.be/GIyR0lMX40s HOW TO MAKE FRESH COCONUT MILK...https://youtu.be/UFw2IXb6qS4 HOW TO MAKE OVEN BAKED CARROT BUNS...https://youtu.be/TSStfwEXHPM HOW TO MAKE CUCUMBER LEMONADE DRINK...https://youtu.be/XIcrAaruV4Y HOW TO MAKE PURE VIRGIN COCONUT OIL....https://youtu.be/I7B7r8EFWy8 HOW TO MAKE 100% PURE ORGANIC AVOCADO OIL FOR YOUR SKIN AND HAIR https://youtu.be/UOzXcAkrDzw HOW TO MAKE KOREAN TWISTED DOUGHNUT...https://youtu.be/sPRrVkovGFU HOW TO MAKE PERFECT SCONES...https://youtu.be/BZ0JXh2_KZA HOW TO MAKE COATED PEANUT...https://youtu.be/nkBt-hi4wS8 HOW TO MAKE NIGERIAN AKARA...https://youtu.be/0SsUgtAG_Sc HOW TO MAKE NIGERIAN CRUNCHY EGG ROLL...https://youtu.be/vja3JAuh_XY HOW TO MAKE CRUNCHY NIGERIAN CHIN CHIN...https://youtu.be/q7V9hx_y2Yc #shirleyskitchencuisine#gingerlemonwater#losebellyfat
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New research is boosting hopes that weight-loss surgery can put some patients' diabetes into remission for years and perhaps in some cases, for good. (March 31)
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