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#drk #medical #medico #diabetes #learnmedical #basicmedical #health #sitagliptin #diabetesdrug #incretins #insulin Sitagliptin is a diabetes drug that works by increasing levels of natural substances called incretins. Incretins help to control blood sugar by increasing insulin release, especially after a meal. They also decrease the amount of sugar your liver makes. What is the mechanism of action of sitagliptin? Sitagliptin increases insulin production and decreases hepatic glucose overproduction. Sitagliptin prolongs the action of GLP-1 and GIP. By enhancing active incretin levels, sitagliptin increases insulin production and lowers glucagon secretion from alpha cells, which decreases hepatic glucose overproduction. How sitagliptin works differently from metformin in the body? Metformin reduces the absorption of sugar from the stomach, reduces the release of stored sugar from the liver, and helps your body use sugar better. Sitagliptin helps to control blood sugar levels by increasing substances in the body that make the pancreas release more insulin. How long does it take for sitagliptin to work? The effect of Januvia (generic name: sitagliptin) on your blood sugar levels may begin quickly, within the first 1 to 2 weeks. You may start to see your blood sugar drop after just a few doses. How does sitagliptin help control blood glucose? It works by increasing the amounts of certain natural substances that lower blood sugar when it is high. Sitagliptin is not used to treat type 1 diabetes (condition in which the body does not produce insulin and therefore cannot control the amount of sugar in the blood) When is the best time to take sitagliptin? You can generally take the tablet at a time of day to suit you, but it is best to take your doses at the same time of day each day. You can take sitagliptin before or after a meal. How sitagliptin works differently from metformin in the body? Metformin reduces the absorption of sugar from the stomach, reduces the release of stored sugar from the liver, and helps your body use sugar better. Sitagliptin helps to control blood sugar levels by increasing substances in the body that make the pancreas release more insulin. How long does it take for sitagliptin to work? The effect of Januvia (generic name: sitagliptin) on your blood sugar levels may begin quickly, within the first 1 to 2 weeks. You may start to see your blood sugar drop after just a few doses. How effective is sitagliptin? Conclusion. In routine clinical practice, sitagliptin produces a significant reduction in mean HbA1c (0.8%) within the first 6 months of use which corresponds to efficacy data obtained in controlled clinical trials.
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Keeping weight off isn’t about quick fixes it’s about supporting your body naturally and staying consistent. Check out this progress from just 24 days with MindBody GLP-1 System. Want to feel more in control of cravings and your wellness? ➡️Tap the link in bio to learn how to get started. #glp1 #HealthConsultant #WellnessJourney, #HealthAndVitality #HealthyLifestyle #GregDieker
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Dr. Christy shares her excitement about Zepbound - going over the data and the reasons why this is moving obesity medicine forward. REFERENCES: https://investor.lilly.com/news-releases/news-release-details/fda-approves-lillys-zepboundtm-tirzepatide-chronic-weight SURMOUNT-1 data: https://www.nejm.org/doi/full/10.1056/NEJMoa2206038 SURMOUNT-2 data: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)01200-X/fulltext
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A look at the new Lean Mass Hyper-responder report by Feldman, Budoff, and Norwitz leading people to claim that high LDL doesn't cause heart disease. Let's look at a whistleblower's claims and over 20 studies for an answer. - Links and Sources - Support Me Here: https://www.patreon.com/micthevegan My Cookbook: https://micthevegan.com/product/mics-whole-vegan-cookbook/ https://www.tiktok.com/@micthevegan https://www.facebook.com/micthevegan https://www.instagram.com/micthevegan - @micthevegan Vegan Bootcamp: https://vbcamp.org/Micthevegan TIY Tiny House Channel: https://www.youtube.com/channel/UCYhthOBh4_459pAge62at8g My New Newsletter Sign-Up: https://mailchi.mp/2785ad113ff7/micthevegan-emails Miami Heart Study: https://www.sciencedirect.com/science/article/pii/S266666772100057X Sitting and Plaque Studies: https://journals.lww.com/jcma/fulltext/2022/01000/prolonged_sitting_time_links_to_subclinical.8.aspx https://www.sciencedirect.com/science/article/pii/S0735109715614462?via%3Dihub BMI and Plaque: https://journals.sagepub.com/doi/10.1177/1479164119825761 Dr Spencer Nadolsky Twitter Thread: https://twitter.com/DrNadolsky/status/1733541113904910667 Carnivore Dieter 90th and 97th Percentile Clogging Case Study: https://www.atherosclerosis-journal.com/article/S0021-9150(22)00975-3/fulltext Standard FH Timeline of CAD Development and Risk: https://www.mp.pl/paim/issue/article/16248/ FH 3x Mortality Risk: https://www.frontiersin.org/articles/10.3389/fcvm.2022.860196/full Severe FH Event Risk: https://www.nature.com/articles/s41598-023-47147-z Severe FH Plaque Reversal: https://www.atherosclerosis-journal.com/action/showPdf?pii=S0021-9150%2821%2900206-9 Genetically Higher HDL Doesn't Lower Risk: https://pubmed.ncbi.nlm.nih.gov/22607825/ Triglycerides 50 vs 100 Risk: https://www.researchgate.net/publication/8152665_Addressing_Cardiovascular_Disease_in_Women_Focus_on_Dyslipidemia Heme Iron, Stroke, and Oxidative Stress: https://www.ahajournals.org/doi/10.1161/strokeaha.112.679662 Heterocyclic Amines and Oxidative Stress: https://pubmed.ncbi.nlm.nih.gov/25812604/ Trans Fat Oxidized LDL Study: https://www.sciencedirect.com/science/article/pii/S0914508717300151 Dietary Oxidized Cholesterol Enters Blood: https://www.sciencedirect.com/science/article/pii/S0022227520311603 Dietary Oxidized Cholesterol Increases Lesions in Mice: https://www.ahajournals.org/doi/full/10.1161/01.ATV.18.6.977 Antioxidants Buffer LDL Oxidation: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6211048/pdf/antioxidants-07-00133.pdf Hyperlipidemia Most Correlated with Oxidized LDL over Diabetes: https://www.ahajournals.org/doi/10.1161/01.atv.21.5.844 LMHR Lipid Energy Model: https://www.mdpi.com/2218-1989/12/5/460 Letter to Editor Warning about LMHR Narrative: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9154254/pdf/nzac042.pdf Intro/Outro Song: Sedução Momentânea by Roulet: http://freemusicarchive.org/music/Roulet/Beats_dAmor/Roulet_-_Beats_dAmor_-_07_Seduo_Momentnea #LMHR #Keto #heartdisease
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🚨 GLP-1 Drugs & Pancreatic Cancer Risk: What You Need to Know 🚨
GLP-1 receptor agonists like Ozempic and Wegovy are heavily marketed for weight loss and diabetes—but are they truly safe?
📚 Research Warning Signs:
A 2013 study in JAMA Internal Medicine found that exenatide and sitagliptin (GLP-1-related drugs) were associated with a 2.24-fold increased risk of pancreatitis and potential precancerous changes in the pancreas.
(Butler et al., JAMA Intern Med. 2013;173(6):534-539)
A 2011 FDA Adverse Event Reporting System (FAERS) review revealed a 6-fold increase in reported pancreatic cancer cases with GLP-1 drugs compared to other diabetes medications.
(Elashoff et al., Gastroenterology. 2011;141(1):150-156)
Long-term concerns were also raised by a 2023 study in Diabetes Care, which showed increased pancreatic enzyme levels in some users, a marker for potential pancreatic stress.
(Kapitza et al., Diabetes Care. 2023;46(1):110-117)
⚠️ These findings don’t prove causation—but they highlight why caution is needed and more long-term research is essential.
📌 If you’re considering GLP-1 drugs, make sure to weigh the benefits against these potential risks—and know there are safer, natural ways to reverse insulin resistance through lifestyle.
#diabetes180 #glp1 #ozempic #wegovy #diabetesreversal #pancreaticcancer #plantbasedhealing