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Orforglipron also reduced blood sugar levels in participants with type 2 diabetes A significant trial of a daily weight-loss pill has found that it helped people to shed the pounds and reduce their blood sugar levels, making it a contender to join the new wave of drugs that combat obesity and diabetes. People who took a 36mg pill of orforglipron lost an average of 7.3kg (16lbs) over nine months, according to results from a phase 3 clinical trial reported by the drug’s manufacturer, Eli Lilly, on Thursday. The trial, which enrolled 559 obese people with type 2 diabetes from the US, China, India, Japan and Mexico, also found that the daily pill reduced blood sugar levels, in some cases bringing them below the formal threshold for diabetes. Results from the trial have been eagerly awaited by health researchers. Orforglipron is a daily pill version of a GLP-1 agonist, the medication used in blockbuster weight-loss injections such as Ozempic and Wegovy. David Ricks, Eli Lilly’s chief executive, said: “As a convenient once-daily pill, orforglipron may provide a new option and, if approved, could be readily manufactured and launched at scale for use by people around the world.” In a statement accompanying the results, the company said the drug met expectations on safety, tolerability, glucose control and weight loss. While weight-loss jabs have soared in popularity, health officials believe that daily pill versions of the medicine could allow more people to control their weight and blood sugar levels. In Britain, two-thirds of adults are either overweight or living with obesity and more than 5 million people have type 2 diabetes. The 40-week trial showed that taking a daily pill of 3mg, 12mg or 36mg reduced blood sugar by 1.2% to 1.5%. During the same period, participants saw their weight drop by an average of 4.5% on the 3mg pill, 5.8% on the 12mg pill and 7.6% on the 36mg pill. The results will be presented at a meeting of the American Diabetes Association in June before publication in a peer-reviewed journal. The company said it would apply for approval to market the drug for weight management later this year and for type 2 diabetes next year. Naveed Sattar, a professor of cardiometabolic medicine at the University of Glasgow, said: “These are important results. Having new oral agents that lower glucose but also meaningfully lower weight well beyond levels seen with most existing diabetes therapies is critical to future type 2 diabetes care. Of course, one caveat is that we do not know the effects of this newer therapy on cardiovascular outcomes but this will be forthcoming in future trials.” - The Guardian

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If you want to build every major muscle with just 6 exercises, a full body split is the way to go. Full body workout plans not only boost growth by training each muscle multiple times a week, but new research suggests they might also enhance fat loss. Five years ago, I shared a full body workout routine. But new research and hands-on experience have shown me how to make it even better. Today, I’m bringing you the upgraded version: a full body workout plan that includes 3 workouts per week — with as few as 6 key exercises per workout. I’ll walk you through all 3 workouts in the full body workout program, breaking down each exercise with science-backed tips. And the best part? You can try this entire routine for free on my new app. Click below to try the workout on the BWS+ app FREE for 2 weeks: https://builtwithscience.com/app Click below to subscribe for more videos: https://www.youtube.com/jeremyethier/?sub_confirmation=1 Timestamps: 0:00 - Full Body Routine Overview 0:42 - Full Body Workout A 8:10 - Full Body Workout B 12:12 - Full Body Workout C 17:36 - Download The Routine To kick off Workout 1 of our full body workout plan, we’ll target the upper chest with the incline dumbbell press for 3 sets of 8-12 reps. The incline dumbbell press is one of the best all-around chest builders. Next, we’re moving to the lower body with squats for 3 sets of 6-8 reps. Research shows they don’t just grow the glutes as effectively as glute-focused exercises like hip thrusts, they also strengthen and grow the quads, adductors, and even your lower back. Next we’re focusing on the mid and upper back muscles with the dumbbell chest-supported row for 3 sets of 8-12 reps. To squeeze out extra growth: once you’ve hit failure on your last set, try to get at least 3-5 more half reps in that bottom position. Next, the hamstrings. You'll want both a leg curl movement and a deadlift-type movement in your workout plan. Today, we’ll focus on the leg curl. And to finish off this full body workout, you have 2 options. If you're using dumbbells, perform a superset of lying incline dumbbell curls for the biceps, then go right into dumbbell overhead extensions shortly after. Repeat that for a total of 3 times. If you're using cables, you can do behind the body cable curls superset with overhead rope extensions. Time for Workout 2 in our full body split. First up, the barbell bench press for 3 sets of 4-6 reps. Next, hamstrings with Romanian deadlifts for 3 sets of 6-8 reps. Then, lat pulldowns for 3 sets of 8-12 reps. Don’t forget: on your last set, push past failure by doing as many full reps as you can, then extend your set with 3-5 half reps in the stretched position to squeeze out extra growth. Next, 3 sets of walking lunges, aiming for about 6-10 reps per leg. To finish up Workout 2, we’ve got another isolation exercise superset with the side delts and abs. For the side delts, I’d recommend behind the body cable lateral raise with the cables set up 3-4 notches up from the bottom. After you’re done, we’ll immediately go into an ab exercise: reverse crunches. Repeat for a total of 3 times.  Alright, that wraps out Workout 2 of our full body workout routine. Time for Workout 3. First, we have the seated dumbbell shoulder press for 3 sets of 8-12 reps. Next up, the dumbbell row, with 3 sets of 8-12 reps. Don’t forget. On your last set, push past failure by doing as many half-reps as you can in the stretched position to maximize growth. Next up, 3 sets of 10-15 reps of hip thrusts. An effective swap are dumbbell step-ups on a bench or platform. To finish off the quads for the week, we’re doing 3 sets of 10-15 reps of leg extensions. Next, we’re working the chest with 3 sets of 10-15 reps of flyes to compliment the pressing we’ve done earlier in the week. My preferred setup is a seated cable fly with a pad or foam roller between my back and the bench for a deeper stretch in the chest. Alright, to finish off the week, we’ve got our final isolation superset, starting with calf raises. For maximum growth, standing calf raises are the way to go. Once you’re done, move straight into reverse cable flyes to target the rear delts. Repeat this superset for a total of 3 sets to wrap up your week of training (and week of full body workout routine). Now, if you’re wondering how to track all of this or remember the form for each move in the full body workout program, BuiltWithScience+, my new app, is designed to do all the heavy lifting for you — except the actual weights, of course. It’s super simple. Just click on the exercise, and you’ve got the form video right there. You can even swap exercises if you’re missing equipment or have an injury, and the app will still make sure you’re still working the right muscles. Plus, it tracks your sets and even starts coaching you after the first week. It’s just like having me with you at the gym. You can try 2 weeks of it for free by simply heading to https://builtwithscience.com/app.

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Are you looking to shed those extra pounds and achieve a healthier weight? If so, then you may want to consider harnessing the power of natural fat burners. These natural ingredients can help boost your metabolism, increase fat burning, and support weight loss in a safe and effective way. By incorporating these fat burners into your diet and lifestyle, you can make significant progress towards achieving your weight loss goals.

The Benefits of Natural Fat Burners

Natural fat burners are a great way to enhance your weight loss efforts. These ingredients work to increase your body’s metabolism, helping you burn more calories throughout the day. They can also help suppress your appetite, making it easier to stick to a healthy diet. Additionally, natural fat burners can improve your energy levels, allowing you to stay active and motivated to exercise regularly.

One of the key benefits of natural fat burners is their ability to target stubborn fat stores in the body. These ingredients can help break down fat cells and release stored fat for energy, resulting in a slimmer and more toned physique. Natural fat burners can also support your overall health and well-being by providing essential nutrients and antioxidants that promote optimal function of your body’s organs and systems.

Unlike synthetic weight loss supplements, natural fat burners are safe and free from harmful side effects. These ingredients are derived from plants, herbs, and other natural sources, making them a healthier alternative for those looking to lose weight. By choosing natural fat burners, you can support your body’s natural processes and promote long-term weight loss without compromising your health.

Top Natural Fat Burners to Include in Your Diet

Green tea extract is a powerful natural fat burner that has been shown to boost metabolism and increase fat oxidation. This ingredient contains catechins, a type of antioxidant that promotes fat loss by stimulating the breakdown of fat cells. Green tea extract can also help reduce appetite and improve energy levels, making it an excellent addition to your weight loss regimen.

Cayenne pepper is another effective natural fat burner that can help increase metabolism and promote fat burning. This spicy ingredient contains capsaicin, a compound that has been shown to boost calorie expenditure and fat oxidation. Cayenne pepper can also help curb cravings and suppress appetite, making it easier to maintain a healthy diet and lose weight.

Coconut oil is a versatile natural fat burner that can be used for cooking, baking, and as a dietary supplement. This healthy fat contains medium-chain triglycerides (MCTs) that can help boost metabolism and promote fat loss. Coconut oil can also improve satiety and reduce calorie intake, making it a valuable addition to your weight loss plan.

Tips for Incorporating Natural Fat Burners into Your Routine

When incorporating natural fat burners into your diet, it’s important to choose high-quality ingredients that are free from fillers and additives. Look for reputable brands that use pure and organic sources of fat burners to ensure their effectiveness and safety. It’s also essential to follow the recommended dosage and guidelines provided on the product label to maximize results and avoid any potential side effects.

In addition to taking fat burner supplements, focus on maintaining a balanced diet rich in fruits, vegetables, lean protein, and whole grains. Stay hydrated by drinking plenty of water throughout the day, as dehydration can slow down your metabolism and hinder fat burning. Incorporate regular exercise into your routine, including cardio, strength training, and flexibility exercises, to maximize the benefits of natural fat burners and achieve long-lasting weight loss.

Remember to consult with a healthcare professional or nutritionist before starting any new supplement regimen, especially if you have underlying health conditions or are taking medication. They can provide personalized guidance and recommendations based on your individual needs and goals. By following these tips and staying consistent with your fat burner routine, you can effectively harness the power of natural ingredients to support healthier weight loss and achieve a leaner, fitter body.

FAQ about Natural Fat Burners

Q: Are natural fat burners safe to use for weight loss?

A: Yes, natural fat burners are generally safe to use for weight loss as long as they are taken in moderation and according to the recommended dosage. It’s important to choose high-quality ingredients and consult with a healthcare professional before starting any new supplement regimen.

Q: How long does it take to see results from natural fat burners?

A: The results from natural fat burners can vary depending on individual factors such as diet, exercise, and metabolism. Some people may see results within a few weeks of starting a fat burner regimen, while others may take longer to experience noticeable changes in weight and body composition.

Q: Can natural fat burners help reduce belly fat specifically?

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A: Yes, some natural fat burners, such as green tea extract and cayenne pepper, have been shown to target abdominal fat and promote fat loss in the midsection. By incorporating these ingredients into your diet and exercise routine, you can effectively reduce belly fat and achieve a slimmer waistline.

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In this video, we'll explore the mechanism of action of diabetic drug Ozempic and its current controversial use for weight loss. This drug has specific criteria and has not been FDA approved for weigh loss. It’s crucial to remember that these drugs should only be used unless prescribed by a healthcare professional. They are not a quick fix for weight reduction and may have adverse effects. Check out our Instagram for a more in-depth look at Ozempic! This video was made by McMaster students Bhavika Nayyar, Umar Hayat, Jhanvi Shah, and Prabhjot Bangar in collaboration with the McMaster Demystifying Medicine Program. This video is provided for general and educational information only. Please consult your health care provider for Information about your health. Copyright McMaster University 2023 Join this channel to get access to perks: https://www.youtube.com/channel/UCEwEYnO7yey-oBzyNu-AauQ/join Subscribe to the McMaster Demystifying Medicine YouTube channel: https://www.youtube.com/c/DemystifyingMedicine References: Anderson, L. A. (2022, May 30). How long does it take for Ozempic to work? Drugs.com. Retrieved March 6, 2023, from https://www.drugs.com/medical-answers/long-ozempic-work-3543031/ Aubrey, A. (2023, January 30). Wegovy works. but here's what happens if you can't afford to keep taking the drug. NPR. Retrieved March 6, 2023, from https://www.npr.org/sections/health-shots/2023/01/30/1152039799/ozempic-wegovy-weight-loss-drugs#:~:text=Ozempic%20is%20approved%20for%20diabetes,at%20risk%20of%20heart%20disease. Blum, D. (2022, November 22). What is Ozempic and why is it getting so much attention? The New York Times. Retrieved March 6, 2023, from https://www.nytimes.com/2022/11/22/well/ozempic-diabetes-weight-loss.html Heiser, T. (2022, August 17). Wegovy vs. Ozempic. Norton Healthcare. Retrieved March 6, 2023, from https://nortonhealthcare.com/news/wegovy-vs-ozempic/#:~:text=What's%20the%20difference%20between%20Wegovy,treatment%20of%20Type%202%20diabetes. Rahman MS, Hossain KS, Das S, Kundu S, Adegoke EO, Rahman MA, Hannan MA, Uddin MJ, Pang MG. Role of insulin in health and disease: an update. International journal of molecular sciences. 2021 Jun 15;22(12):6403. Written By Heather Smith RN, H. G. (2022, November 17). What is glucagon, and what does it do? Healthgrades. Retrieved March 6, 2023, from https://www.healthgrades.com/right-care/endocrinology-and-metabolism/glucagon

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Navigating the Changing Landscape of Compounded GLP-1 Medications: A State-by-State Update In this episode of The Downsized, Christopher Durham follows up on recent developments impacting access to compounded GLP-1 medications like Tirzepatide and Semaglutide. Christopher begins by recounting the live session with attorney and TikTok creator Lee fits in, who discussed the state regulations emerging in Nevada, Georgia, and Ohio. These regulations, spurred by changes in federal law and backed by court rulings, are restricting the compounding and distribution of these medications. In Nevada, a pharmacy board notice has banned compounded GLP-1s due to the FDA removing Tirzepatide and Semaglutide from the shortage list. The Georgia Board of Nursing circulated a letter from Eli Lilly stating that compounded Tirzepatide is illegal, leading to uncertainty among nurses and nurse practitioners. In Ohio, several med spas and pharmacies have been shut down due to violations, including unsafe practices and mislabeling. Nationally, pharmaceutical giants Eli Lilly and Novo Nordisk are launching lawsuits to halt the practice of compounding GLP-1 medications, arguing against their legality post-shortage list removal. Christopher emphasizes that these compounded medications have significantly helped him and his wife lose weight and manage comorbidities. He advises patients to proactively discuss options with their doctors, consider stocking up within legal limits, and explore branded alternatives if compounded medications become unavailable. Christopher urges the manufacturers to lower their prices to eliminate the need for compounded alternatives and to build trust and loyalty among patients. The episode underscores a critical juncture in the battle for accessible and affordable healthcare, particularly for those dependent on GLP-1 medications for obesity. DOWNSIZED GLP-1 COMPANION PRODUCT STORE: https://thedownsized.org/downsized-store Join CLUB DOWNSIZED: https://www.youtube.com/@thedownsized/join DOWNSIZED WEBSITE: https://thedownsized.org/ FOR SPONSORSHIPS, BRAND DEALS & COLLABS: https://thedownsized.org/contact/ 00:00 Introduction and Overview 01:52 Nevada's Ban on Compounded GLP-1s 03:09 Georgia's Response and Concerns 04:39 Ohio's Enforcement Actions 06:51 Legal Backdrop and Federal Lawsuits 09:00 Advice for Patients 11:24 Message to Manufacturers 13:58 Conclusion and Community Support

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