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Professor Barry Borlaug presents the SUMMIT trial on the use of the GIP / GLP-1 receptor dual agonist in patients with obesity-associated Heart-Failure with Preserved Ejection Fraction, which has been published in New Engl J Med 2024 and elected the most important study in cardiology and lipidology 2024 by MARKUS at HOMe.
Dr. Borlaug is Professor of Medicine and Director, Circulatory Failure Research, Division of Cardiovascular Diseases, and Chair for Research, Division of Circulatory Failure, Department of Cardiovascular Medicine at the Mayo Clinic, Rochester, Minnesota.
He is a global leader in studies on mechanisms, diagnosis and treatment of heart failure, particularly heart failure with preserved ejection fraction (HFPEF).
The interview was recorded on January 16th, 2025.
Moderators: Prof. Dr. Dr. Stephan Schirmer (Kaiserslautern, Germany), Prof. Dr. Florian Custodis (Saarbrücken, Germany) and Prof. Dr. Gunnar Heine (Frankfurt, Germany).
Articles discussed:
GLP-1 receptor agonists are promising but unproven treatments for alcohol and substance use disorders.
Leggio L, Hendershot CS, Farokhnia M, Fink-Jensen A, Klausen MK, Schacht JP, Simmons WK.
Nat Med 2023
doi: 10.1038/s41591-023-02634-8
Tirzepatide Reduces LV Mass and Paracardiac Adipose Tissue in Obesity-Related Heart Failure: SUMMIT CMR Substudy.
Kramer CM, Borlaug BA, Zile M MR, Ruff D, DiMaria JM, Menon V, Ou Y, Zarante AM, Hurt KC, Murakami M, Packer M; SUMMIT Trial Study Group.
J Am Coll Cardiol 2024
doi: 10.1016/j.jacc.2024.11.001
Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity.
Packer M, Zile MR, Kramer CM, Baum SJ, Litwin SE, Menon V, Ge J, Weerakkody GJ, Ou Y, Bunck MC, Hurt KC, Murakami M, Borlaug BA; SUMMIT Trial Study Group.
N Engl J Med 2024
doi: 10.1056/NEJMoa2410027
Effects of tirzepatide on circulatory overload and end-organ damage in heart failure with preserved ejection fraction and obesity: a secondary analysis of the SUMMIT trial.
Borlaug BA, Zile MR, Kramer CM, Baum SJ, Hurt K, Litwin SE, Murakami M, Ou Y, Upadhyay N, Packer M.
Nat Med 2024
doi: 10.1038/s41591-024-03374-z
Evidence Supporting the Existence of a Distinct Obese Phenotype of Heart Failure With Preserved Ejection Fraction.
Obokata M, Reddy YNV, Pislaru SV, Melenovsky V, Borlaug BA.
Circulation 2017
doi: 10.1161/CIRCULATIONAHA.116.026807
An evidence-based screening tool for heart failure with preserved ejection fraction: the HFpEF-ABA score.
Reddy YNV, Carter RE, Sundaram V, Kaye DM, Handoko ML, Tedford RJ, Andersen MJ, Sharma K, Obokata M, Verbrugge FH, Borlaug BA.
Nat Med 2024
doi: 10.1038/s41591-024-03140-1
A Simple, Evidence-Based Approach to Help Guide Diagnosis of Heart Failure With Preserved Ejection Fraction.
Reddy YNV, Carter RE, Obokata M, Redfield MM, Borlaug BA.
Circulation 2018
doi: 10.1161/CIRCULATIONAHA.118.034646
How to diagnose heart failure with preserved ejection fraction: the HFA-PEFF diagnostic algorithm: a consensus recommendation from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC).
Pieske B, Tschöpe C, de Boer RA, Fraser AG, Anker SD, Donal E, Edelmann F, Fu M, Guazzi M, Lam CSP, Lancellotti P, Melenovsky V, Morris DA, Nagel E, Pieske-Kraigher E, Ponikowski P, Solomon SD, Vasan RS, Rutten FH, Voors AA, Ruschitzka F, Paulus WJ, Seferovic P, Filippatos G.
Eur J Heart Fail 2020
doi: 10.1002/ejhf.1741
Dapagliflozin Enhances Arterial and Venous Compliance During Exercise in Heart Failure With Preserved Ejection Fraction: Insights From the CAMEO-DAPA Trial.
Tada A, Burkhoff D, Naser JA, Harada T, Pourmussa B, Reddy YNV, Jensen MD, Carter RE, Demmer RT, Testani JM, Chirinos JA, Borlaug BA.
Circulation 2024
doi: 10.1161/CIRCULATIONAHA.124.068788
Cardiac and Metabolic Effects of Dapagliflozin in Heart Failure With Preserved Ejection Fraction: The CAMEO-DAPA Trial.
Borlaug BA, Reddy YNV, Braun A, Sorimachi H, Omar M, Popovic D, Alogna A, Jensen MD, Carter R
Circulation 2023
doi: 10.1161/CIRCULATIONAHA.123.065134
Milton Clinic Weight Loss Program Example Biscuits
Download the FREE HASfit app:
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Are fat burners the key to weight loss? 🔥 Dr. Mike Israetel dives into the truth about fat burners, their effectiveness, and what really works for shedding fat. Learn the science behind fat loss! 💪 #MikeIsraetel #FatBurners #WeightLossTips #FatLossJourney #NutritionScience #FitnessFacts
Credit - Chris Willamson Fat loss Science Podcast With Dr Mike Israetel we are not associated with mike israetel or any youtuber, we post clips cut from their podcast in the hope for it to reach more people
Eli Lilly Weight Loss Pill Shows Promising Results In Phase 3 Trials
Are you looking for a natural and effective way to support your weight loss goals? Simply Health ACV Keto Gummies may be the solution you’ve been searching for. These gummies are designed to help boost metabolism, curb cravings, and promote fat burning, all while having the added benefits of apple cider vinegar and keto-friendly ingredients. But do they really live up to their claims of being simply effective? Let’s dive into some reviews and find out.
Customer Reviews
One customer, Sarah, shared her experience with Simply Health ACV Keto Gummies, stating that she noticed a significant decrease in her appetite after incorporating the gummies into her daily routine. She also mentioned that she felt more energized throughout the day, which helped her stay on track with her weight loss journey. Overall, Sarah was pleased with the results she saw from using the gummies.
Another customer, John, was skeptical at first but decided to give the gummies a try. He was pleasantly surprised by how much they helped control his cravings and prevent him from overeating. John mentioned that he felt more motivated to exercise and make healthier food choices while taking the gummies. He noted that he was able to lose a few pounds within the first few weeks of using the product.
One more customer, Emily, shared that she struggled with bloating and digestive issues, which were hindering her weight loss progress. After incorporating Simply Health ACV Keto Gummies into her routine, she noticed a significant improvement in her digestion and a reduction in bloating. Emily was happy that the gummies were able to address her issues while also supporting her weight loss goals.
Ingredients and Benefits
Simply Health ACV Keto Gummies contain a powerful blend of ingredients that work together to support weight loss and overall health. Apple cider vinegar is known for its ability to boost metabolism and promote fat burning. It also helps regulate blood sugar levels and curb cravings, making it a great addition to any weight loss supplement. The gummies also contain keto-friendly ingredients like MCT oil, which can help increase energy levels and support ketosis.
One of the key benefits of Simply Health ACV Keto Gummies is their convenience. Unlike traditional apple cider vinegar supplements or keto pills, these gummies are easy to take on the go. You can simply pop a few gummies in your mouth whenever you need a boost of energy or support for your weight loss goals. This convenience makes it easier to stay consistent with taking the gummies, which can lead to better results in the long run.
In addition to their weight loss benefits, Simply Health ACV Keto Gummies also support overall health and well-being. The ingredients in the gummies have antioxidant properties that can help protect cells from damage and reduce inflammation in the body. This can lead to a stronger immune system and improved skin health, among other benefits. By incorporating these gummies into your daily routine, you can support your weight loss goals while also promoting a healthier body.
Side Effects and Considerations
While Simply Health ACV Keto Gummies are generally safe for most people to use, there are some potential side effects to be aware of. Some users may experience digestive issues like bloating or diarrhea when first starting to take the gummies. This is usually temporary and should subside as your body adjusts to the ingredients. It’s important to start with a small dose of the gummies and gradually increase it to assess your tolerance.
It’s also important to note that Simply Health ACV Keto Gummies are a supplement and should not be used as a replacement for a healthy diet and exercise routine. For best results, it’s recommended to use the gummies in conjunction with a balanced diet and regular physical activity. While the gummies can help support your weight loss goals, they are not a magic solution and should be used as part of a comprehensive lifestyle approach to health and wellness.
If you have any underlying health conditions or are taking any medications, it’s always best to consult with your healthcare provider before starting any new supplement regimen. They can help determine if Simply Health ACV Keto Gummies are right for you and provide personalized guidance based on your individual health needs. By taking the time to talk to your healthcare provider, you can ensure that you are using the gummies safely and effectively.
Kelly Clarkson S Weight Loss Secret Revealed
http://www.BuiltLean.com - Have you heard of the term "lean body mass" before, but didn't understand what it meant, or even why it's important? I answer your questions in the video.
Here's a link to the full article: http://www.builtlean.com/2011/08/24/lean-body-mass-definition-formula/
MARK: Hi I'm Mark Perry the creator of BuiltLean.com
and today I'm going to answer the frequently
asked question,
which is "What is lean body mass?"
It's also known as LBM.
I talk a lot about it on my website, and I
finally wanted to
address it.
So, lean body mass is the simple definition:
Everything in your body besides fat.
So, what are we talking about?
We're talking about your blood, your bones,
your organs, your muscle, your skin.
Again, anything that is not body fat.
And just so you know how to calculate it,
essentially, you need your body fat percentage.
It's a little tricky sometimes, arriving at your
body fat percentage,
I prefer to use a skin fold caliper, you can also use
what's called Bioelectrical impedance analysis,
which is kinda, you know, holding onto those,
you know, kinda machines
Or, also you can do it by stepping on a scale
as well, but again, I strongly prefer calipers,
specially if you have under 30% body fat.
So once you have the body fat percentage calculation,
you're gonna take your total body weight,
multiply it by your body fat percentage,
and that's gonna give you
your fat in pounds.
Now, to get your LBM you're gonna take your
total body weight, subtract if from your fat pounds,
now you got your LBM.
And so, why is that so important?
Why is your LBM so important?
Well, fundamentally, how to get lean,
is losing fat without losing muscle.
So how do you know if you are not losing muscle?
If you don't have an LBM calculation,
you don't know if you're losing muscle.
So, having the LBM will allow you.
Let's just say you're about 180 pounds.
Right? You got, 30 pounds of body fat,
If you lose, you know, let's just say,
50 pounds of fat, without losing your LBM,
then, your body fat percentage will obviously
decrease,
however, if you're losing half LBM, and half fat,
your body fat percentage is not gonna change so much.
So that's one reason why I always talk about
the LBM, you wanna keep the LBM
you have, or increase it
and lose as much fat as you possibly can,
or that's reasonably healthy.
And so, I hope that's been helpful,
please do ask more questions, I'd love to
answer them, and I will see you next week.
