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In this first episode, I am mainly talking about how and why I became interested in learning more about GLP-1 agonists. Future episodes will discuss what these peptides do and why lifestyle changes should be paired with the use of them.
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🎙️EP282｜善纖達，猛健樂，所有GLP-1受體促效劑：減重、控糖、護心腎？從藥物比較到臨床應用全解析 — 📌主題亮點： • GLP-1受體促效劑的作用機轉是什麼？為何能兼顧控糖與體重管理？ • Tirzepatide、Semaglutide、Liraglutide 怎麼選？療效與副作用比較一次看懂 • 台灣健保給付限制、仿單外使用、心腎保護證據，全方位解析臨床現況 — 🔍內容解析： 本集重點： GLP-1受體促效劑（Glucagon-like peptide-1 receptor agonists, GLP-1 RAs）是目前糖尿病與肥胖症領域中最受矚目的藥物類別之一。這類藥物最初設計目的是控制第二型糖尿病血糖，但其延緩胃排空與降低食慾的機制，逐漸展現出優異的體重控制效果，成為減重治療的重要選項。 本集將全面比較目前臨床上常見的 GLP-1 RAs，包括 Semaglutide、Liraglutide、Dulaglutide、Exenatide、Tirzepatide 等，從作用機制、臨床療效、安全性，到心腎保護與健保給付現況，帶你掌握這波醫藥創新的核心。 — 🧩主題分段解析： — 🧬 GLP-1作用機轉：多重代謝效應的關鍵介質 GLP-1 是人體腸道於進食後釋放的一種腸泌素，具有多重生理功能： • 刺激胰島素分泌（在高血糖狀態下） • 抑制昇糖素分泌 • 延緩胃排空，增加飽足感 • 對中樞神經產生抑制食慾作用 GLP-1受體促效劑則是模擬這一生理訊號的藥物。由於天然 GLP-1 在體內迅速被 DPP-4 分解，因此這類藥物皆經修飾以延長半衰期，使其可每日或每週注射。 ⸻ 🩺 臨床療效比較：控糖與體重減輕雙重奏 根據大型隨機試驗與統合分析，GLP-1 RAs 在控制血糖（HbA1c）與體重管理上皆展現出顯著成效。 📌 各藥物臨床成效對比： 藥物名稱 HbA1c 降幅 體重減輕效果 使用頻率 核准適應症 Semaglutide -1.4 ~ -1.9% -6~15% 每週1次 第2型糖尿病、肥胖（國際核准） Tirzepatide -2.0 ~ -2.4% -10~20% 每週1次 第2型糖尿病（減重待核准） Liraglutide -1.0 ~ -1.5% -5~8% 每日1次 糖尿病、肥胖（Saxenda商品名） Dulaglutide -0.7 ~ -1.5% -2~5% 每週1次 糖尿病 Exenatide -0.8 ~ -1.0% -2~3% 每週或每日 糖尿病 其中 Tirzepatide 屬於 GIP/GLP-1 雙重受體促效劑，在 SURMOUNT 與 SURPASS 試驗中展現出前所未有的血糖控制與減重表現，有望改寫治療標準。 — 💖 心血管與腎臟保護：超越控糖的新方向 越來越多研究指出，GLP-1 RAs 除了降血糖與減重，也具有心腎保護效果，這點在糖尿病病人族群中特別重要。 📌 心血管研究亮點： • LEADER試驗（Liraglutide）： 減少 MACE（重大心血管事件）13% • SUSTAIN-6（Semaglutide）： 顯著降低心血管事件與腎功能惡化風險 • REWIND（Dulaglutide）： 在高風險群中降低中風與心臟衰竭住院率 腎臟方面，GLP-1 RAs 可延緩 eGFR 下降速度、降低蛋白尿發生，與 SGLT2i 一同被納入 CKD 病患用藥建議中（KDIGO 2022）。 — ⚠️ 常見副作用與風險考量 GLP-1 類藥物最常見的不良反應是胃腸道不適： • 噁心、嘔吐、腹瀉（劑量上升時尤明顯） • 厭食、味覺改變 此外，也需注意以下安全議題： 1. 胰臟炎風險： 少見但需警惕，特別是胰臟病史者 2. 甲狀腺 C 細胞腫瘤： 動物實驗有顯示，故有甲狀腺腫瘤病史者應避免使用 3. 低血糖風險： 單用風險低，但與 SU 類或胰島素併用時需留意 4. 腎功能不全： 輕中度 CKD 可使用，但末期腎病需個別評估 目前各大指引皆建議以「緩慢劑量上升」的方式起始治療，以改善耐受性。 — 📋 台灣市場與健保現況：法規限制與臨床建議 雖然 GLP-1 RAs 在國際間已被廣泛應用於肥胖與代謝症候群治療，但在台灣市場仍受到幾項限制： 1. 健保給付範圍有限： 僅核准用於第二型糖尿病患者，且常須 HbA1c ＞ 7.5% 且合併肥胖者 2. 體重管理為仿單外使用： 減重用途目前無正式健保核准 3. 高藥價問題： 自費族群常成經濟負擔障礙 4. 專科醫師使用限制： 多數藥品須由內分泌科或新陳代謝科開立 根據 NHIA 公告，目前 Semaglutide（Ozempic）與 Liraglutide（Victoza）皆列為給付藥品，但需符合嚴格條件。 — 🚶♀️ 臨床應用建議：如何選擇最適合的 GLP-1 受體促效劑？ 臨床選擇應考慮以下因素： • 目標： 控糖為主或減重為主？ • 用藥頻率接受度： 每日注射 vs 每週注射 • 腎功能狀況 • 副作用耐受性 • 病患偏好與經濟狀況 📌舉例： • 對減重有高度期待者：Tirzepatide ＞ Semaglutide ＞ Liraglutide • CKD早期患者：Semaglutide、Dulaglutide皆可考慮 • 容易噁心者：可考慮低劑量起始且選擇耐受性較佳者如 Dulaglutide • 自費負擔有限者：評估 Liraglutide 台灣仿單內使用是否適用 — 📣負責任的行動： GLP-1 受體促效劑不只是「減重神藥」，而是結合代謝改善、心腎保護與控糖成效的複合型療法。醫師在使用前應評估患者整體代謝風險、心血管病史與用藥習慣，避免將此藥物視為「萬靈丹」。 病患亦應接受完整衛教，了解可能副作用與正確使用方法，避免自行停藥或過度依賴。 — 📚熱門關鍵字： #GLP1受體促效劑 #Semaglutide #Ozempic #Tirzepatide #Mounjaro #Liraglutide #Saxenda #減重藥物 #糖尿病治療 #心血管保護 #腎臟保護 #胰島素促進劑 #胃排空延緩 #體重管理 #胃腸道副作用 #甲狀腺C細胞腫瘤 #台灣健保給付 #仿單外使用 #慢性腎病新療法 #糖尿病臨床指引 — 🎤主講人資訊： Dr.Happy Human Plumber｜心血管知識推廣者 擅長將複雜代謝藥物與心腎內科整合知識，轉化為清晰易懂的內容，關注台灣臨床處方趨勢與全球新藥發展，致力於提升醫病雙方的治療選擇品質。 Powered by Firstory Hosting (https://firstory.me/zh)
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