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Breaking Down Cagrisema: Novo Nordisk's Next Big Obesity Drug In this episode, Christopher Durham from the Downsized channel discusses Novo Nordisk's promising new experimental drug, Cagrisema, which aims to treat obesity more effectively. Durham delves into the unique composition of Cagrisema, combining semaglutide with an additional compound, cagrilintide, which together target multiple hormonal pathways to enhance weight loss results. He also touches on the logistical challenges Novo Nordisk has faced with GLP-1 medications like Ozempic and Wegovy, including shortages and manufacturing bottlenecks. Durham highlights the ongoing clinical trials for Cagrisema, expected timelines for market availability, and the company's extensive efforts to scale up production capacity. He also explained the innovative work of developing a more efficient single-chamber injection pen for future use. This episode provides comprehensive insights into Cagrisema's potential to revolutionize obesity treatment and addresses the critical hurdles in bringing such a groundbreaking medication to market. We use Mochi Health: https://joinmochi.com/. Use Laraine’s code for $40 off: QIYGO8. DOWNSIZED WEBSITE: https://thedownsized.org/ JOIN CLUB DOWNSIZED: https://www.youtube.com/@thedownsized/join DOWNSIZED GLP-1 COMPANION PRODUCT STORE: https://thedownsized.org/downsized-store 00:00 Introduction to Cagrisema 00:25 Meet the Hosts 00:33 Our GLP-1 Journey 01:04 Overview of Cagrisema 01:50 The GLP-1 Market Landscape 02:50 Supply Chain Challenges 05:18 What Makes Cagrisema Unique 06:09 Clinical Trial Results 07:18 Manufacturing and Delivery Systems 10:12 Future Prospects and Conclusion

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In this episode of the Lean and Lethal Podcast, Bridger Deaton tackles the most common questions about fitness and nutrition, delivering evidence-based answers to help you cut through the noise. From protein needs and muscle building to weight loss, supplements, and the truth about alcohol, this episode is packed with actionable insights to help you optimize your health and performance. Whether you’re wondering how much protein you really need, how to train for hypertrophy, or why you can’t seem to lose stubborn belly fat, Bridger breaks it all down in his no-nonsense style. Plus, he debunks myths like ‘carbs after 6 PM’ and explains why sleep quality is just as important as your workout routine. 00:00 - Introduction to Lean and Lethal Podcast 01:19 - Understanding Protein Needs for Muscle Building 03:57 - Gaining Muscle Without Excess Fat 05:52 - Optimal Training Frequency and Volume 08:45 - Rep Schemes and Hypertrophy 10:07 - Supplements: Creatine vs. BCAAs 12:03 - Caloric Needs for Weight Loss 15:02 - Alcohol’s Impact on Fitness Goals 16:59 - Addressing Stubborn Belly Fat 18:55 - Exercise vs. Diet in Fat Loss 22:17 - Debunking Carbs After 6 PM Myth

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