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I was sent this multiple times and had to respond. He mentions his patient lost 2/3 of his weight from lean body mass while using Semaglutide, which is a GLP-1 agonist and approved for obesity under the name Wegovy (also for type 2 diabetes as Ozempic).
The expected lean mass loss from weight loss in general is around 20-30% so if what he is saying is true, that would be a really big deal. Except it’s not.
There was a subgroup analysis done in the Step 1 trial showing close to a 40% lean mass loss. That is a tad higher than what would be expected, but honestly I’ve never actually seen it and I oversee one of the largest if not the largest companies who prescribes and manages these medicines. To top it off, tirzepatide, which is even more powerful than Semaglutide for weight loss, hits around that 25% lean mass loss.
I have requested DEXA scans from my patients and most have reported below 30% lean mass lost with many in the 10% or lower range. My patients do lift weights which may mean it’s a selection bias, but either way.
I would ask that we stay objective about medicine. We can be scientific without fear-mongering. I will be studying this extensively to know if there is truly an issue, but as far as I can see practically, it isn’t.
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Weight loss can be a challenging journey for many individuals, but with the introduction of semaglutide, a medication that aids in weight loss, it has become more achievable than ever. Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that works by reducing appetite and food intake, leading to significant weight loss in those struggling with obesity. While taking semaglutide can provide positive results, combining it with strategic approaches can further maximize weight loss outcomes. In this article, we will explore various strategies to help you make the most of your weight loss journey on semaglutide.
Healthy Eating Habits
One of the most crucial strategies to maximize weight loss on semaglutide is adopting healthy eating habits. Since semaglutide works by reducing appetite, it is important to focus on nutrient-dense foods that will provide your body with the necessary vitamins and minerals without unnecessary calories. Incorporating plenty of fruits, vegetables, lean proteins, and whole grains into your diet can help you feel full and satisfied while promoting weight loss. It is also essential to be mindful of portion sizes and avoid high-calorie, processed foods that can hinder your progress.
Furthermore, practicing mindful eating can help you develop a better relationship with food and listen to your body’s hunger and fullness cues. Paying attention to how your body responds to different foods can help you make more informed choices and avoid overeating. Additionally, staying hydrated by drinking plenty of water throughout the day can support your weight loss efforts and prevent dehydration, a common side effect of semaglutide.
Another effective strategy to enhance weight loss on semaglutide is incorporating regular physical activity into your routine. Exercise not only helps burn calories but also improves overall health and well-being. Aim for a combination of cardiovascular exercises, such as running or swimming, and strength training exercises, such as weightlifting or bodyweight exercises, to maximize weight loss and build lean muscle mass. Finding activities that you enjoy and can sustain long-term will help you stay motivated and consistent with your workouts.
Stress Management
Managing stress levels is another important aspect of optimizing weight loss on semaglutide. Chronic stress can lead to emotional eating, hormone imbalances, and poor sleep, all of which can hinder your weight loss progress. Incorporating stress-reducing activities into your daily routine, such as meditation, yoga, deep breathing exercises, or spending time in nature, can help lower cortisol levels and improve your overall well-being.
Additionally, getting an adequate amount of quality sleep is essential for weight loss and overall health. Lack of sleep can disrupt hunger hormones, increase cravings for high-calorie foods, and negatively impact your metabolism. Aim for 7-9 hours of sleep per night and establish a bedtime routine to promote restful sleep. Creating a relaxing environment in your bedroom, such as keeping the room dark and cool, can further enhance the quality of your sleep.
Support System
Building a strong support system can greatly enhance your weight loss journey on semaglutide. Surrounding yourself with family, friends, or a support group who understand your goals and can provide encouragement, accountability, and motivation can make a significant difference in your success. Sharing your progress, challenges, and victories with others can help you stay on track and navigate any obstacles that may arise.
Furthermore, seeking professional help from a nutritionist, dietitian, therapist, or personal trainer can provide you with expert guidance and personalized strategies to maximize weight loss on semaglutide. These professionals can help you develop a customized meal plan, exercise routine, and coping mechanisms to address any barriers to weight loss and support your overall well-being. Don’t hesitate to reach out for help and leverage the expertise of others to optimize your results.