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In this episode of the Ayık Kafa podcast, Dr. Sandra Kaufmann, MD. In this 2nd part of our 2-part podcast series, she discusses her unique approach to longevity and aging, emphasizing the importance of cellular health. Dr. Kaufmann is an award-winning physician who specialized in pediatric anesthesia at Johns Hopkins, served as Chief of Pediatric Anesthesia at Joe DiMaggio Children’s Hospital, and founded The Kaufmann Anti-Aging Institute, where she developed a comprehensive theory of aging science. She shares her theories on aging, “The 7 Tenets” of cellular decline, and the significance of DNA repair and epigenetics. Last week, we covered the first 3 principles of the Seven Tenets. In this episode, we complete the set: Tenet 4 is Quality Control: how cells repair damaged DNA and proteins, and clean up waste through autophagy. Tenet 5 is Immune Balance: why a bad immune system increases the risk of chronic inflammation, infections, and cancer. Tenet 6 is Cellular Characteristics: each cell type, like brain, bone, or skin, has its own lifespan and nutritional needs. And Tenet 7 is Waste Management: how advanced glycation end products (AGEs), the sugar-related junk, are stopped and cells kept clear. The podcast concludes with a focus on glycation and its detrimental effects on health, highlighting the need for effective waste management in the body. She discusses various aspects of health, longevity, and the role of supplements and pharmaceuticals in maintaining well-being. She highlights the critical role of sirtuins in cellular health and longevity, the importance of sleep and circadian rhythms, and the interaction between AMP kinase and mTOR in energy regulation. She emphasizes the importance of understanding the mechanisms behind aging and how to mitigate damage through lifestyle choices and targeted interventions. The discussion covers topics such as trans-glycosylating agents, the impact of diet soda, navigating toxins in modern life, the use of GLP-1 agonists, and her unique approach to supplement recommendations through the Kaufmann rating system. She shares her personal experiences with medications and supplements, highlighting the importance of a multifactorial approach to health. #EsraÇavuşoğlu #AyıkKafa #ElevatingLifeEvolvingHealth #Longevilab #DrSandraKaufmann Dr. Sandra Kaufmann, MD: Website: https://kaufmannprotocol.com/bio Instagram: https://www.instagram.com/kaufmannlongevity/ *Collaborations & Sponsors: https://dotshub.com/ Special thanks to T.C. Istanbul Gedik University https://www.gedik.edu.tr/en/ *To subscribe to our channel 👉* https://www.youtube.com/@ayikkafa *Dr. Esra Çavuşoğlu, PhD* Instagram: https://www.instagram.com/esracavusoglu/ https://www.instagram.com/longevilab Web: https://www.longevilab.com/hakkimizda#esra-cavusoglu *To Reach Us 👉* [email protected] *About Ayık Kafa* Dr. Esra Çavuşoğlu, PhD, took her studies, starting from her personal treatment experiences and continuing with her clinical psychology education, to the next level by completing her PhD focused on Addiction. Dr. Esra in Ayık Kafa podcast discusses the world’s latest technologies, protocols, products and research in the fields of Biohacking and Longevity, while sharing first-hand information and experiences about the Disease of Addiction, as well as her latest academic studies. *About Dr. Esra Çavuşoğlu, PhD* Longevilab's founder, Dr. Esra, is a United States and internationally trained clinical psychologist and a certified addiction therapist in New York. She served as International Development Advisor on the Yale University Faculty of Medicine Clinical Advisory Board. She is the founder and supervisor of Gaziantep Oya Bahadır Yüksel Rehabilitation Center, Dr. Esra is the designer and implementer of the Turkey Rehabilitation Model. Dr. Esra founded the Contemporary Addiction Studies Association (ÇABAÇAD) in order to combat Turkey's growing addiction problem.

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