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Join Megan Erspamer, RN, BSN, as she walks a patient through everything they need to know about starting GLP-1 medication, specifically tirzepatide. From when to inject to step-by-step instructions on how to inject, this video covers it all. If you're new to tirzepatide or want a clear guide on the injection process, this consultation offers practical tips and expert advice. Subscribe for more health and wellness guidance!" PremierU Med 🩵 🌐 https://premierumed.com 📱 1-618-750-5433 📍Swansea, IL 📍St. Louis, MO 📍Marion, IL #glp1 #tirzepatide #tirzepatideweightloss #tirz #glp1medication #glp1forweightloss #weightloss #medicalweightloss #inflammation #reducedinflammation #modernmedicine #modernmedicineforyourlifestyle #lifestyle #functionalmedicine
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In this video, I dive deep into the reasons behind the infamous “GLP plateau”—that frustrating point where fat loss on GLP-1 peptides like semaglutide, tirzepatide, and retatrutide comes to a grinding halt. I break down the physiological, hormonal, and lifestyle factors that drive plateaus, plus practical, science-backed solutions to get results moving again.
If you’re struggling with stalled progress, this is the most comprehensive breakdown you’ll find on how to identify, understand, and push through GLP plateaus.
Let’s break it all down step by step:
⸻
Timestamps
0:00 – Introduction: Why Do GLP-1 Plateaus Happen?
0:35 – Why Weight Loss Plateaus Are Universal
1:22 – How GLP-1s Work (Mechanisms: Semaglutide, Tirzepatide, Retatrutide)
2:36 – Typical Weight Loss Trajectory on GLP-1s
3:18 – When (and Why) Most People Plateau
4:55 – Plateau ≠ Failure: The New Weight Set Point
5:39 – Physiological & Metabolic Causes of Plateaus
6:26 – Resting Metabolic Rate Drop & Adaptive Thermogenesis
7:31 – Decreased Thermogenesis, Exercise Efficiency, & Mitochondria
8:42 – Muscle Loss and Its Impact on Plateaus
9:44 – NEAT (Non-Exercise Activity Thermogenesis) Drops
10:18 – Why the Body Adapts: Our Ancestral Survival Mechanism
11:06 – Hormonal Adaptations: Leptin, Ghrelin, Insulin
13:03 – Leptin Drop: Increased Hunger, Lower Metabolism
13:41 – Ghrelin Rise: Appetite Returns
15:17 – Insulin, Metabolic Health & Fat Loss
17:20 – Thyroid Hormones: T3, Metabolic Rate, and the Plateau
19:03 – Cortisol, Stress, and Fat Storage
20:07 – Sex Hormones: Testosterone, Fat Loss, and Plateaus
21:46 – Amylin, Neuropeptide Y, and Brain Pathways
22:44 – Behavioral & Lifestyle Factors: NEAT, Adherence, Calorie Creep
24:44 – Psychological Fatigue, Sleep, Diet Quality, & Hydration
28:27 – Is It a True Plateau? Body Fat vs. Weight Loss
28:32 – Pharmacological Tolerance & Dosing Issues
30:00 – Appetite Pathways and Receptor Desensitization
31:52 – Dose Ceiling: When More Isn’t Always Better
33:26 – Strategies to Break Through a Plateau
34:16 – Re-evaluating Diet: Macros, Sugar Diet, and Tracking
34:45 – Activity, Resistance Training, and NEAT
35:03 – Sleep, Stress, Thyroid, and Other Medications
35:44 – Add-On Pharmacology: LDN, Cagrilintide, Leptin Analogs
37:01 – Mitochondrial Pathways: BAM15, SLU-PP-332, Carnitine
37:50 – Cycling, Refeeds, and Metabolic Resensitization
39:55 – Fasting, Intermittent Fasting, and Nutrition
40:08 – Recap: Everyone Plateaus—How Will You Respond?
41:02 – Thank You & Outro
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