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Key Points Question Are glucagon-like peptide-1 receptor agonists semaglutide and liraglutide, which were originally introduced for the treatment of type 2 diabetes and are frequently prescribed due to their weight loss properties, associated with disproportionately increased reporting of suicidality? Findings This disproportionality analysis through the case-control design based on the World Health Organization global database collecting suspected adverse drug reactions, identified a disproportionality signal of suicidal ideation with semaglutide, which remained significant when comparing semaglutide with dapagliflozin and metformin and in the subgroup of patients with coreported use of antidepressants and benzodiazepines. Meaning A detected signal of semaglutide-associated suicidal ideation warrants urgent clarification. Abstract Importance Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have gained use primarily due to their weight-reduction effects, although a regulatory review was undertaken for potential suicidality concern. Objectives To evaluate potential signals for suicidal and self-injurious adverse drug reactions (ADRs) associated with the GLP-1 RAs semaglutide and liraglutide. Design, Setting, and Participants Disproportionality analysis through the case-control design using the World Health Organization (WHO) global database of suspected ADRs. Participants were clinical patients worldwide experiencing an ADR suspectedly attributable to semaglutide or liraglutide in the database from inception to August 30, 2023. Data were analyzed from September to December 2023. Exposure Treatment with semaglutide or liraglutide regardless of indication or treatment duration. Main Outcomes and Measures Reporting odds ratio (ROR) and the bayesian information component (IC) with 95% CIs were calculated as measures of disproportionate reporting of suicidal and self-injurious ADRs associated with semaglutide and liraglutide compared with all other medications. Sensitivity analyses were conducted including patients with coreported use of antidepressants and benzodiazepines and using dapagliflozin, metformin, and orlistat as comparators. A disproportionality signal was considered when the lower limits of the ROR and IC were above 1 and 0, respectively. Results A total of 107 (median [IQR] age 48 [40-56] years; 59 female patients [55%]) and 162 (median [IQR] age 47 [38-60] years; 100 female patients [61%]) cases of suicidal and/or self-injurious ADRs were reported between November 2000 and August 2023 with semaglutide and liraglutide, respectively. Significant disproportionality was detected only for semaglutide-associated suicidal ideation (ROR, 1.45; 95% CI, 1.18-1.77; IC, 0.53; 95% CI, 0.19-0.78), which remained significant in patients with coreported use of antidepressants (ROR, 4.45; 95% CI, 2.52-7.86; IC, 1.96; 95% CI, 0.98-2.63) and benzodiazepines (ROR, 4.07; 95% CI, 1.69-9.82; IC, 1.67; 95% CI, 0.11-2.65), when compared with dapagliflozin (ROR, 5.56; 95% CI, 3.23-9.60; IC, 0.70; 95% CI, 0.36-0.95), metformin (ROR, 3.86; 95% CI, 2.91-5.12; IC, 1.20; 95% CI, 0.94-1.53) and orlistat (ROR, 4.24; 95% CI, 2.69-6.69; IC, 0.70; 95% CI, 0.36-0.95). Conclusions and Relevance This study using the WHO database found a signal of semaglutide-associated suicidal ideation, which warrants urgent clarification.
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facts on metformin explained in Tamil in this video, here you can find the details of what is metformin? How metformin is made? The side effects of metformin and also the misuse of metformin. Metformin also used for other purposes such as #weight loss #PCOD #cancer treatment and #anti ageing all those facts are briefly explained in this video. நவீன மருத்துவத்தில் நீரிழிவுக்கு வழங்கப்படும் பிரதான சிகிச்சையான Metformin மருந்து பற்றிய தெளிவுக்கு இந்த வீடியோவை பார்க்கவும். சமூக வலைத்தளங்கள் மூலம் இணைய Facebook-https://www.facebook.com/drlavapirathan Tictok-https://vm.tiktok.com/ZGJB6SWD5/
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00:00 - GLP-1 Drugs Fail to Provide Key Weight-Loss Benefit 01:55 - Weight-Loss Drugs and Fitness: UVA Health Study Finds Surprising Results 04:25 - GLP-1 Weight Loss Drugs: The Hidden Muscle Loss Risk You Need to Know 1. GLP-1 Drugs Fail to Provide Key Weight-Loss Benefit Doctors may need to recommend exercise programs or develop other approaches, such as nutrition supplements or complementary medications, to help GLP-1 patients get the full cardiorespiratory benefits of substantial weight loss, new research suggests. University of Virginia experts warn in a new paper that these drugs fail to provide essential improvements in heart and lung function needed for long-term health. While GLP-1 drugs help many people drop significant amounts of weight, they do not significantly enhance cardiovascular fitness (VO2max) or improve blood-sugar control, leading to potential risks for patients already at risk for malnutrition or low muscle mass. Researchers emphasize that weight loss associated with these drugs has clear health benefits but requires additional strategies to ensure long-term well-being. 2. Weight-Loss Drugs and Fitness: UVA Health Study Finds Surprising Results A recent study from UVA Health reveals that popular weight-loss drugs, such as Ozempic and Wegovy, may lead to significant weight loss, but they do not substantially improve cardiorespiratory fitness, which is a critical predictor of mortality. This means that while patients may see a reduction in body weight, they may not experience an improvement in physical fitness. The researchers suggest that incorporating exercise and adequate dietary protein intake into the weight-loss regimen could help maximize the health benefits of these medications. The study also notes that patients on GLP-1 medications lose a significant amount of fat-free mass, including muscle, which can impact posture, physical function, and overall well-being. The research team emphasizes the importance of maintaining muscle mass while using these drugs for weight loss. #WeightLoss #Fitness #Health #UVAHealth #Ozempic #Wegovy #CardioFitness #GLP1 #agriculturetechnology 3. GLP-1 Weight Loss Drugs: The Hidden Muscle Loss Risk You Need to Know Discover the surprising truth about popular weight-loss medications like Ozempic and Wegovy! UVA Health experts reveal critical insights: • How GLP-1 drugs can cause unexpected muscle mass reduction • Why losing 'fat-free mass' impacts your overall health • Essential strategies to protect your muscle mass while losing weight Key takeaways from leading endocrinologist Dr. Zhenqi Liu: - Weight loss medications aren't a one-size-fits-all solution - Potential risks to metabolic health and body function - Importance of protein-rich diet and exercise Protect your health, understand the full picture of weight loss medications. Consult your healthcare provider and make informed decisions about your wellness journey.