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Metformin: Mechanism of action
Metformin is an oral anti-diabetic drug, which belongs to biguanide class. It is the only drug available in this class.
Still now it’s difficult to find a full explanation of the mechanism of action of metformin.
However, the primary effect of metformin is to activate the enzyme adenosine monophosphate activated protein kinase which is also called AMPK.
Metformin activates AMPK enzyme in liver which inhibits the gluconeogenesis. The inhibition of gluconeogenesis leads to decrease glucose production.
Patient with type 2 diabetes have considerably less fasting glycemia as well as lower post prandial hyperglycemia after administration of metformin. Also hypoglycemia is rare during metformin therapy. That’s why it is more appropriately termed as euglycemic agent.
There are other mechanisms also, like:
It increases the insulin sensitivity
Increases the fatty acid oxidation
Decreases the intestinal glucose absorption
Medical disclaimer: Medinaz Academy does not provide medical advice. The content available in our books and videos, on our website, or on our social media handles do not provide a diagnosis or other recommendation for treatment and are not a substitute for the professional judgment of a healthcare professional in diagnosis and treatment of any person or animal. We intend to provide educational information only. The determination of the need for medical services and the types of healthcare to be provided to a patient are decisions that should be made only by a physician or other licensed health care provider. Always seek the advice of a physician or other qualified healthcare provider with any questions you have regarding a medical condition.
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Homemade salad | weight loss diet
High Protein diet
Total Carbs: ~43.7g approx
Total Fiber: ~8.6g approx
Total Protein: ~31.6g approx
Total Calories: ~500 kcal approx
Ingredients
1. Lettuce
2. Onion
3. Tomato
4. Cucumber
5. Boiled chickpeas (120gm)
6. Paneer (100gm)
7. Curd (100gm)
8. Salt
9. Black pepper
10. Oregano
11. Chilli Flakes
12. Garlic
13. Pizza Pasta Sauce (homemade)
14. Water
15. Olive oil
For chickpeas
1. Add a little bit of olive oil in the pan, then add boiled chickpeas to it
2. Then sprinkle some salt, black pepper, oregano, and red chilli powder and let it cook for about 4 to 5 minutes.
For paneer
1. In a pan, add little bit of olive oil, then add Paneer cubes, then add little bit of salt, black pepper, oregano, and chilli flakes
2. Let it cook for about 4 to 5 minutes.
For dressing
1. Add Paneer 30 g, then add hundred grams of curd, 5 to 6 cloves of garlic, salt, black pepper, oregano, pizza, pasta sauce, and a little bit of water.
2. Grind everything well, and our dressing is ready.
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