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"It's not that we have non-responders. It's that we have unrealistic expectations." - 00:20:38 A Personal Insight from Greece: Aligning Your Environment with Your Energy Dr. Novitsky begins by sharing a story from her trip to Greece, where the simplicity of her surroundings inspired her to declutter her home. This serves as a metaphor for aligning one's environment with their energy and current needs. Common Concerns About GLP-1 Agonists Dr. Novitsky discusses why people often struggle with GLP-1 agonists. Two main reasons stand out: confusion over how to balance medication with nutrition and exercise, often accompanied by shame, and the belief that they are "non-responders" to the medication. How a Nutrition Audit Can Help For those who feel they are non-responders, Dr. Novitsky introduces the concept of a nutrition audit. By tracking food intake without changes for a week, clients can gather data on calories, protein, carbs, fat, fiber, and added sugars. This helps uncover what might be hindering progress. The Importance of Caloric Deficits and BMR Dr. Novitsky explains that GLP-1 agonists don't guarantee weight loss. Weight loss still requires a caloric deficit, which means consuming fewer calories than one's basal metabolic rate (BMR). Many mistakenly believe they’re in a deficit when they’re not, leading to frustration. Leptin Resistance and Weight Loss Struggles The episode dives into leptin resistance, a condition that can make weight loss harder, even when someone is consuming fewer calories. Leptin plays a role in hunger and metabolism, and resistance to it may be a reason some struggle with weight loss. Patience and Realistic Expectations Dr. Novitsky stresses patience when using GLP-1 agonists, explaining that weight loss varies by individual. Inflammation, body composition, and initial body fat all play a role in determining how quickly one may lose weight. She advises setting realistic goals to avoid discouragement. Looking Ahead Dr. Novitsky wraps up by encouraging listeners to reflect on their own journey, asking them to consider if any of the factors discussed apply to their experience. She teases upcoming episodes that will provide further insights into GLP-1 agonists and weight loss strategies. Resources: The Muscles & Mindset Beginner Strength Training Program - 12 months for only $199! ⁠Enroll TODAY⁠. Nutrition Training Program for Healthcare Professionals is enrolling now! You can ⁠learn more HERE⁠. Dr. Ali's Advanced Strength Training program is now available for exercises at a higher level. See the details ⁠HERE⁠. Optimal GLP-1 Weight Loss Program - next program starts November, 2024.  Learn more and join the waitlist ⁠HERE⁠. Transform® 9.0 enrollment is now open! Get started with your bonus content today. ⁠Learn more HERE⁠. Follow Dr. Ali Novitsky on ⁠TikTok⁠ | ⁠Facebook⁠ | ⁠Instagram⁠ | ⁠YouTube⁠ Subscribe to The Muscles and Mindset Podcast on ⁠Spotify⁠ | ⁠Apple Podcasts⁠ *Ali Novitsky MD, this podcast, and podcast write-up are NOT providing medical advice. We do not recommend you start any exercise program without first consulting with your doctor!* Timestamps 00:00:00 - Introduction and Excitement for the Episode 00:00:12 - Exploring GLP-1 Agonist Non-Responders 00:00:24 - Personal Story: The Impact of Simplicity 00:02:41 - The Importance of Evaluating Your Surroundings 00:03:33 - Understanding Non-Responders: The Nutrition Audit 00:04:05 - Conducting a Nutrition Audit 00:05:39 - Basal Metabolic Rate Explained 00:07:16 - Caloric Intake and Weight Loss 00:08:19 - Leptin Resistance and Its Effects 00:10:07 - Nourishment vs. Muscle Loss 00:10:38 - Key Components of a Nutrition Plan 00:11:55 - Time and Patience in Weight Loss 00:12:58 - Setting Realistic Expectations 00:16:44 - Understanding Muscle Loss Concerns 00:18:48 - Phases of Weight Loss and Expectations 00:20:38 - Conclusion and Upcoming Episode Teaser 00:21:10 - Promoting Fitness and Coaching Programs

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Listen to the full episode here https://bengreenfieldfitness.com/fatlosspodcast Several months ago, I filled you in on "The 2 Best Ways To Burn Fat Fast (Without Destroying Your Hormones Or Metabolism)". But what you learned in that article only scratched the surface of the multiple mechanisms underlying why the human body can be resistant to fat loss, and how to achieve truly sustainable, long-lasting weight loss in a safe and efficient manner. So during today's solosode, you'll discover... -How fat actually gets burnt...6:20 Law of conservation of mass: Mass, in an isolated system, is neither created nor destroyed by chemical reactions or physical transformations Fat is primarily disposed of via the breath Calories, as well as excess carbs and proteins, are converted into triglycerides and stored in lipid droplets of adipocytes Excess dietary fat undergoes lipolysis, and then reesterification Triglycerides are composed of carbon, hydrogen, and oxygen Oxidation: requires inhalation of oxygen Study: When someone loses weight, where does the fat go? For 22 pounds of fat to be oxidized, 64 pounds of oxygen must be inhaled Results in 61 pounds of carbon dioxide excreted via the lungs and 24 pounds of water excreted via urine, sweat, feces, and breath Average of 17,000 breaths per day will excrete .32 lbs of carbon Sources of carbon (other than eating coal) are: dietary carbs, proteins, and fats If you didn't get all that, get this: Losing fat means consuming less carbon than you've exhaled. Even small quantities of food can foil your efforts at weight loss. The simple solution is to move more and eat less. The 16 reasons you're not burning fat the way you'd like – Chronic Inflammation...12:35 High levels of transforming growth actor beta cause irregular appetite and glucose regulation Matrix metalloproteinases (MMP): calcium-dependent zinc-containing endopeptidases Vascular endothelial growth factor (VEGF): Aids in the growth of new blood vessels; correlated with obesity Nitric oxide synthase Toll-like receptor 4 (TLR4) = meta inflammation Nos uncoupling (genetic factors) StrateGene Tree of Life, Bob Miller's site Sugar can be inflammatory but is more quickly metabolized than things like vegetable oil Chronic stress is a factor: overstimulation of the limbic system Cell Danger Response (CDR) Toxic by Neil Nathan Dr. Robert Naviaux – Glycemic variability (GV)...21:05 Refers to the blood glucose variations during the day If GV gets out of control, the body does one of two things: transfers sugar into muscles, or stores as body fat It will become fat tissue if you're not active enough throughout the day Be "ruthlessly" cognizant of blood sugar fluctuations 6 Strategies to control GV Strength training Pre-breakfast fasted cardio Book: Change Your Schedule, Change Your Life  Post-prandial walk Standing Plants, herbs, spices Ceylon cinnamon Gymnema sylvestre Berberine Apple cider vinegar Kion Lean Fiber – Cortisol and stress...30:45 Cortisol suppresses insulin secretion Measure heart rate variability (HRV) Oura Ring (Save $50 with code: GREENFIELDOURA) Podcast with building biologist Brian Hoyer Podcast Ep. 397 – Sleep deprivation...34:20 A single night of partial sleep can be deleterious Neuro endocrine effect: reduces levels of leptin; increases levels of ghrelin – Snacking and post-workout calories...35:25 "Grazing" or 6-8 small meals per day is a myth Snacking increases your GV and eliminates benefits of fasting Your body releases more growth hormone during intermittent fasting Grazing throws metabolism into sugar burning mode It takes 3 days, or 4 weeks of extreme calorie restriction for the body to down regulate metabolism The need for protein and carbs right after a workout is a myth The exception: two a day workouts – You're not moving enough...39:47 Fool your body into thinking it's in the "hunter gatherer" mode – Too much exercise...41:30 Excessive exercise, along with other stressors can lead to increased levels of cortisol and inflammation Beyond Training by Ben Greenfield Too much of the same exercise Not enough recovery days Sweet spot: 2-3 days per week, lift heavy stuff 2-3 days high-intensity interval training – Chronic cardio...43:35 Your body will catabolize muscle and store fat High-intensity cardio 2-3 days per week Reduced subcutaneous adiposity of body fat among people who follow these guidelines – The SAID Principle...46:00 Specific Adaptation to Imposed Demands Sometimes the best workout plan is the one you're not currently doing Keep the body guessing 5 modifications: Combine exercises Article "complex exercises" Active rest periods Train outside Change the center of gravity Workout at a different time of day – Lack of cold therapy...50:00 Cold is a strong metabolic stimulus Cold thermogenesis occurs when protons are forced across the inner membrane and turned into heat Beige adipose tissue Every day, 2-5 minutes cold exposure (cold shower, cold river or lake) 3x3 cold coolfatburner.c

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The Benefits of Xultophy Insulin. Xultophy insulin offers several key benefits that set it apart from traditional diabetes medications. One of the primary advantages is its ability to provide better blood sugar control. By combining a long-acting insulin with a GLP-1 receptor agonist, Xultophy helps regulate blood sugar levels throughout the day, reducing the risk of spikes and dips that can be detrimental to one's health. In addition to blood sugar control, Xultophy insulin also has the potential to promote weight loss. Many individuals with diabetes struggle with weight management, as the condition can make it more challenging to maintain a healthy weight. Xultophy addresses this issue by incorporating liraglutide, a GLP-1 receptor agonist known for its weight loss benefits. This dual-action medication not only helps manage blood sugar levels but also supports weight loss efforts. Another advantage of Xultophy insulin is its convenient dosing regimen. With this medication, individuals only need to administer a single injection once a day. This eliminates the need for multiple injections throughout the day, providing a more streamlined and user-friendly approach to diabetes management. The simplicity of Xultophy's dosing regimen can significantly improve adherence to medication, leading to better overall diabetes control. How Xultophy Insulin Works. Xultophy insulin combines two active ingredients:. insulin degludec and liraglutide. Insulin degludec is a long-acting insulin that provides a steady release of insulin throughout the day, mimicking the body's natural insulin production. This helps regulate blood sugar levels and reduces the risk of spikes and dips. Liraglutide, on the other hand, is a GLP-1 receptor agonist that stimulates the release of insulin, slows down digestion, and reduces appetite. By incorporating liraglutide into the formulation, Xultophy not only provides insulin but also supports weight loss efforts, making it an excellent option for individuals struggling with weight management alongside diabetes. When administered as a single injection, Xultophy combines the benefits of both insulin degludec and liraglutide, offering a comprehensive approach to diabetes management. The combined action of these two drugs helps regulate blood sugar levels, promote weight loss, and simplify the medication routine for individuals living with diabetes. Dosage and Administration Guidelines. The dosage of Xultophy insulin may vary depending on individual needs and the guidance of a healthcare provider. It is essential to follow the prescribed dosage instructions and consult with a healthcare professional for personalized advice. Xultophy insulin is typically administered once a day, preferably at the same time each day. The injection should be given subcutaneously, which means it is injected into the fatty tissue just beneath the skin. The specific injection site may vary, but common areas include the abdomen, thigh, or upper arm. Before administering Xultophy insulin, it is crucial to carefully read the instructions provided with the medication. The injection should be prepared according to the manufacturer's guidelines, ensuring proper mixing and preparation. It is recommended to rotate injection sites to prevent any potential skin reactions or complications. It is essential to monitor blood sugar levels regularly while using Xultophy insulin to ensure optimal control. Regular check-ups with a healthcare provider are also important to assess the effectiveness of the medication and make any necessary adjustments to the dosage or treatment plan. Potential Side Effects and Precautions. Like any medication, Xultophy insulin may cause side effects in some individuals. Common side effects include nausea, diarrhea, and injection site reactions such as redness or swelling. These side effects are usually mild and tend to resolve over time as the body adjusts to the medication. However, if these side effects persist or worsen, it is important to seek medical advice. In rare cases, Xultophy insulin may cause more severe side effects, including pancreatitis, hypoglycemia, or allergic reactions. Symptoms of pancreatitis may include severe abdominal pain, nausea, and vomiting. Hypoglycemia, or low blood sugar, can cause symptoms such as dizziness, confusion, sweating, and rapid heartbeat. ----- "DISCLAIMER: The content of this video is for informational and educational purposes only. It should not be used as a substitute for medical consultation. You should always seek the advice of your doctor or healthcare professional before taking any medication or starting any treatment. Treatments and medications should be prescribed and supervised by a qualified medical doctor only. Individual results may vary and the effectiveness of any treatment mentioned in this video is not guaranteed. Do not self-medicate, if you have any health problems, it is important to seek medical help immediately.

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