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GLP1 drugs are highly effective at weight loss, but it comes at a cost. The approach requires expertise and oversight from an expert. There are several strategies that can help prevent or manage muscle mass loss associated with GLP-1 agonist treatment: ## Resistance Training Incorporating resistance or strength training exercises is one of the most effective ways to preserve and build muscle mass during weight loss[1][2]. This counteracts the catabolic effects of caloric deficit by stimulating muscle protein synthesis. ## Adequate Protein Intake Ensuring sufficient dietary protein intake, ideally 1.6-2.2 g/kg of ideal body weight per day, can help minimize muscle loss[2]. Protein provides amino acids needed for muscle maintenance and repair. ## Combining with Myostatin Inhibitors Myostatin is a key negative regulator of muscle growth. Blocking myostatin with investigational drugs like apitegromab (SRK-439) from Scholar Rock may enhance muscle growth and prevent muscle loss when combined with GLP-1 agonists[1]. Early clinical trials are underway to test this approach. ## Using Activin Receptor Inhibitors Activin receptor inhibitors like those being developed by companies like Regeneron can block activin signaling and potentially increase muscle mass when used alongside GLP-1 medications[3]. ## mTOR Activators The mTOR pathway regulates muscle protein synthesis. Drugs that activate mTOR, such as the PPAR agonist enobosarm being tested by Veru, may preserve muscle when combined with GLP-1 treatment[5]. ## Adequate Vitamin D and Calcium Ensuring sufficient vitamin D and calcium intake is important for preserving bone mineral density, which can be impacted by the weight loss and muscle loss induced by GLP-1 agonists[2]. The key is utilizing a multi-modal approach combining GLP-1 agonists with resistance exercise, optimal nutrition, and emerging muscle-preserving medications to maximize fat loss while minimizing the loss of metabolically active lean muscle mass[1][2][3]. Citations: [1] https://pharmanewsintel.com/features/addressing-muscle-loss-associated-with-glp-1-medication-use [2] https://www.medscape.com/viewarticle/994030 [3] https://www.tctmd.com/news/dont-worry-about-muscle-loss-glp-1-inhibitors-viewpoint-asserts [4] https://www.uclahealth.org/news/article/rapid-weight-loss-can-lead-loss-muscle-mass [5] https://www.drugdiscoverytrends.com/glp-1-impact-lean-mass/
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In this video, I'll break down the Skinny Fat System—a 3-step method to get rid of the skinny fat body type for good. If you feel soft, lack muscle, and struggle with stubborn fat, this is the exact strategy to transform your physique. You'll learn how to fix your diet for fat loss and muscle gain, the best training approach to build definition, and the key lifestyle changes that make results stick. No more confusion—just a clear roadmap to a lean, muscular body. Watch until the end for a game-changing tip, and don’t forget to like, subscribe, and comment for more skinny fat transformation advice. Enjoy 🤘🏼 The video I reference (How I Help Skinny Fat Men, Step-By-Step): https://youtu.be/CPpmcEbTApg If you want my help to lose 20-30 lbs of stubborn fat while building muscle & confidence in 180 days, just like I did for 100+ people… Book a call here: https://calendly.com/stopskinnyfat/strategycall On the call we will: • Discuss your journey and go over exactly what you need to start your transformation • Build a strategy for your fat loss & muscle gain • Discuss whether you’d be a good fit for the program, and if you are, get you started If you want results like: My client Rob who lost 16 lbs of stubborn body fat in 70 days. He built lasting strength and muscle definition. Or my client Marco who went from skinny fat to toned using The Muscle Metabolism. His discipline grew so much and he is now the best version of himself possible. Or my client Kyle, who was struggling to lose body fat for the last 3 years and now within 3 months has lost 25 pounds of his bodyweight! That's fat he will never put on again. …then book a call & let’s chat to see if you’d be a good fit for The Muscle Metabolism Method https://calendly.com/stopskinnyfat/strategycall -------------------------------------------------- Follow me on IG (You’ll instantly get a six-pack) Instagram: https://www.instagram.com/stopskinnyfat/ -------------------------------------------------- P.S. If you have any comments or questions - drop them below Topics covered in this video: skinny fat, how to fix skinny fat, skinny fat solution, skinny fat transformation, skinny fat workout, how to get rid of skinny fat, build muscle and lose fat, body recomposition, lose fat build muscle, skinny fat diet, best workout for skinny fat, how to lose belly fat, lose stubborn fat, lean muscle growth, fix skinny fat physique, fat loss for skinny fat, weight training for skinny fat, best diet for skinny fat, muscle building for beginners, Jeremy Ethier, Jeff Nippard, Athlean-X, Greg Doucette, Kinobody, Gravity Transformation, More Plates More Dates, Thomas DeLauer, Sean Nalewanyj, Alpha M, Frazier Fitness, fitness transformation, gym motivation, body transformation, fat loss tips, muscle gain tips, fitness for men, how to get lean, best way to burn fat, home workout for skinny fat, gym workout for beginners, aesthetic physique, shredded physique, how to get ripped, lose fat without losing muscle, best macros for fat loss, training for lean muscle, intermittent fasting for skinny fat, best supplements for fat loss, calorie deficit for fat loss, best protein sources for muscle growth, how to gain muscle and lose fat at the same time.
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#podcast #jameyjohnson #news Welcome to the 24th episode of The Chris & Kadie Show featuring hosts Boston Chris & Kadie Lynn! This week Chris & Kadie discuss 39 Outside the box Christmas gift ideas, Jamey Johnson getting arrested, Elton John's Box Office FLOP, Jelly Roll's weight loss journey, The CMAs and more! In this week's show we also play the What the Heck game! We also list our top 5 favorite Christmas Songs! This week's Kadie's Corner has Kadie quitting her job, inhaling Packing Peanuts & more! In this episode we discuss the following topics: 00:00: Intro 03:55: Top 5 Favorite Christmas Songs 16:54: Kadie’s Corner 25:56: Boston plays What the Heck?! 31:56: Jamey Johnson Arrested in Tennessee 44:53: Elton John’s Musical Cancelled with the QUICKNESS 52:55: Jelly Roll’s Weight Loss Journey 1:07:39: 39 Outside the Box Christmas Gift Ideas 2:05:33: Outro Buy ALL NEW Merch from the show here: https://boston-chris-gaming.creator-spring.com/listing/the-chris-kadie-show Check out ALL the episode of The Chris & Kadie Show here: https://youtube.com/playlist?list=PLRVUGoqJJ6AfeGd6fbyounJgu3bNCwyOr&si=RWsGOWYXEpW7yt4E If you would like to have a question answered on a future episode please use this email: ►Email: [email protected] Support Kadie Lynn ►Website: https://www.kadielynn.com ► Twitter: / kadielynn ► Instagram: / kadielynnofficial ► Facebook: / kadieroberson Support Boston Chris 💵Become a Member: https://www.youtube.com/channel/UCao6fJOfevnE7dkMYz3vnQQ/join 👕Merchandise Store: https://boston-chris-gaming.creator-s... 🎧Purchase Hyper X Products: https://hx.hyperx.gg/BG5FiQXA 💵Donate to Paypal: https://www.paypal.me/etxrocks Follow Boston Chris ► Twitter https://twitter.com/BostonChrisTTV ► Instagram https://www.instagram.com/bostonchristtv/ ► TikTok https://www.tiktok.com/@itsbostonchris ► Facebook: https://www.facebook.com/TheBostonChrisShow ► Discord https://discord.gg/TkyV9Q2P ► Twitch: https://www.twitch.tv/thebostonchrisshow ► Other Stuff: https://linktr.ee/bostonchris Check out the Podcasts: ► The Chris & Kadie Show YouTube: https://www.youtube.com/playlist?list=PLRVUGoqJJ6AfeGd6fbyounJgu3bNCwyOr ► The Chris & Kadie Show Spotify: https://open.spotify.com/show/4UhHqi95KXlVXzoofzLdKz?si=c335a7dd569f4dec ► 10 Minutes with Boston Chris YouTube: https://www.youtube.com/playlist?list=PLRVUGoqJJ6AdL2KbXbyB59e-_AOktJbah ► 10 Minutes with Boston Chris Spotify: https://open.spotify.com/show/5UeR5tgIGsltEMUh0a22h8?si=b10432ece9ec4db0
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Forcing Fat Loss (and keeping muscles safe) - This is probably the most difficult part of any cutting/fat-loss diet. With your aim to lose as much fat as possible, the error most people make is to pitch the calories too low for their body and as such create a “famine” environment which have certain very unwanted reactions in the body. This “famine” environment result in a drastic amount of muscle-mass being lost amongst other things. In most scenarios this is much more than the actual fat you are losing. Many people say they do not care about this fact, but what they do not realize is that the muscle mass they carry plays a significant role in their bodies energy burning/metabolic rate. Muscle mass is one of the biggest factors in determining your base metabolic rate. Plus a body without little muscles will NEVER look as good as a body with the good muscle mass – muscle give shape to a body. If you loose your muscle you might be slim but will always look floppy and shapeless. The best approach is ALWAYS (!) to pitch the daily calories consumed such, that you lose maximum fat and minimum muscle. Now how does one do that? The problem everyone is facing is the fact that not any two of our bodies are the same. Our bodies reaction to the same amount of calories differ from person to person. The following factors are just some of the reasons why: Your past few years diet routines Your past few years exercise routines or lack thereof. How frequently you eat meals and the sizes thereof. Your amount of muscle mass on your body. Your age. And many more… So if you think you can grab a diet from a book or of the internet and plug in to reach success – WRONG! Here is a process that you can apply to adjust any diet to function optimally for your body. In other words a process to align the calories consumed to allow your body to primarily burn fat and not muscle. The process: Start with a sample cutting diet (see diet in video: “Advanced cutting method delivering superior results”) Every 14 days you need to re-align the calorie amounts depending on how your body reacted in this previous 14 day period. The realignment process: Weight yourself in on a scale Fat calliper pinch measurements on abs, chest, shoulders, upper and lower arms, upper and lower legs, upper and lower back and back of neck. All these measurements together paint a picture: Should the scale be down but fat calliper readings stayed the same, it shows muscle loss and diet must be adjusted across the board with and 10% increase in calories. This must be done every two weeks until such time that the scale drops but fat callipers measurements dropped as well...this is called your sweet spot where your body is NOT in a famine environment but you feed it just enough to protect the muscles and start loosing the fat reserves. Should the fat calliper measurements show an increase and the scale increased as well, then you are consuming too much calories and must cut calories across the board with a 10% factor and redo above monitoring after 14 days. This must be done until such time that you hit the sweetspot. GertFITNESS sites: [YOUTUBE] https://www.youtube.com/c/GertFITNESS [Official Fitness site] http://www.gertlouw.com [COMPLETE TRANSFORMATION program] http://gertlouw.wordpress.com/my-transformation-program/ [Bodybuilding page] https://bodyspace.bodybuilding.com/ScoobyMuscle/ [Facebook] https://www.facebook.com/Scoobymuscle [Twitter] https://twitter.com/GertFITNESS [Pinterest] https://www.pinterest.com/GertFITNESS/ [Tumblr] http://gertlouw.tumblr.com/ [Instagram] https://instagram.com/gertfitness/ Happy training! Cheers... Gert Louw