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In this episode of the Pharm So Hard Ambulatory Care Podcast, the hosts discuss various studies and trials related to GLP-1 medications for weight management and cardiovascular outcomes. They provide updates on their personal lives and share their experiences with different vehicles, such as Jeeps and Broncos. The studies discussed include the Surmount 1 study, which showed significant weight loss in patients without diabetes; the Risk of Gastrointestinal Adverse Events Associated with GLP-1s study, which highlighted potential side effects of GLP-1 medications; the SELECT trial, which demonstrated the effectiveness of semaglutide in reducing cardiovascular events in patients with obesity and pre-existing cardiovascular disease; and a phase 2 trial of Retro-True Tide, a triple hormone receptor agonist that showed impressive weight loss results. The hosts also discuss the limitations and implications of these studies. Takeaways • GLP-1 medications have shown significant weight loss in patients without diabetes. • GLP-1 medications may have gastrointestinal side effects, but the overall risk is small compared to the potential benefits. • Semaglutide has been shown to reduce cardiovascular events in patients with obesity and pre-existing cardiovascular disease. • Retro-True Tide, a triple hormone receptor agonist, has shown impressive weight loss results in a phase 2 trial. • It is important to consider the limitations and implications of these studies when evaluating the use of GLP-1 medications.

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Learn through this video about yet another new approach to manage type 2 diabetes. What are GLP-1 or glucagon-like peptide receptor agonists? They are essentially incretin mimetics. And, what are their cardiovascular enhancing benefits in controlling diabetes.  Dr. Sharad Jaitly further explains in this video. Insight: Management of diabetes type 2 has new novel approaches now with GLP-1 agonists class of drugs (injectables) like, exenatide, liraglutide and dulaglutide.  No adverse cardiovascular increased risks reported thus far in the trials conducted; however, a distinct advantage clearly seems to be seen with the liraglutide which has been shown to reduce risk of MI, CVA & cardiovascular deaths and renal protection as well shown in the LEADER trial;  and therefore, FDA has added this as a very specific distinct indication for the use of the drug wherever cardio-renal protection is required or desirable. GLP-1 agonists also called incretin mimetics work by potentiating the actions of incretin to increase insulin secretion, suppressing the glucagon output, delaying the gastric emptying time so less glucose is absorbed, and also thereby decreasing the food intake as well.  There is also weight loss and BP reduction by few mm, some of the very desirable effects in the setting of diabetes. MuniMeterHealth.com, a division of MuniMeter, LLC, is the world premiere online video library on cardiology and the human heart. Our goal is to increase medical education for physicians AND to enhance patient health literacy. This is just the beginning my friends, spread medical knowledge AND love to the world. MuniMeterSTHealth is our latest offering of new content and is available in up to 2160p 4K resolution. Please enjoy and we will do our best to respond to all of your comments/questions/suggestions. We wish you the best in cardiac care and education for the rest of your life! MuniMeter.com is the crown jewel of MuniMeter, LLC. MuniMeter.com is the entire NYC Subway System on film, and more. A major city has never been filmed before in such high capacity and volume, in 1920x1080 HD, by one person - and all handmade. It will never be replicated and it will never be done again. Explore NYC as never before on MuniMeter.com and join the comMUNIty. Dr. Sharad C. Jaitly MD., FACC: Dr. Jaitly is a renowned health educator and entrepreneur. He is Chief Medical Officer and Chief Digital Lecturer of MuniMeterHealth.com (MMH). MMH is a free online video library for individuals from all around the world to learn about a wide spectrum of subjects surrounding cardiology and the human heart. Currently the library consists of several hundred videos in English, but also a few in Hindi. Dr. Jaitly was born in Calcutta and raised in Nagpur, India. He is a graduate from Government Medical College Nagpur, and has received extensive training in Internal Medicine at Mount Sinai (NY) and a specialty in Cardiovascular Diseases at Cornell Medical Center (NY). Dr. Jaitly is board certified in Internal Medicine, Cardiovascular Diseases, Nuclear Cardiology, and Advanced Echocardiography. He is an avid swimmer and loves nature. Muni S. Jaitly: Mr. Jaitly is CEO & Founder of MuniMeter, LLC - a next generation digital content production company and community. He is a former investment banker. Mr. Jaitly received an MBA from Columbia, MS from St. John’s, and BA from NYU. He is a credited Emmy Award winner by NBC Olympics. The future is here. (January 2018) DISCLAIMER: If you are experiencing a medical emergency, please call your doctor immediately and/or and ambulance and/or rush to the nearest hospital. MuniMeterHealth videos should not be used for medical advice. These videos are exclusively available for medical education purposes only. Consult directly with your own doctor for all clinical advice and care. MuniMeterHealth videos were made in good faith and were published during the month and year in parentheses listed directly above the disclaimer. Please be aware that research and knowledge of the human body may have changed since the published date. The content produced is not an authoritative source for address, geographic, medical, or other information. MuniMeter, LLC and MuniMeterHealth do not guarantee authenticity. MuniMeter, LLC is not liable for any behavior triggered by this content. Rather, our comprehensive video platform should be used to simply better understand the human heart, how it functions, and how to keep it healthy. We are doing our very best for you. Live a healthy life and live long! 210 New Hypoglycemic Agents GLP 1 Agonists, What Are They? Copyright © 2018 MuniMeter, LLC

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