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When we eat a meal containing carbohydrates a peptide called GLP-1 is released into the blood and acts in several ways to improve glucose regulation. It stimulates insulin release from the pancreas, increases insulin sensitivity, and suppresses appetite. A peptide called exenatide originally discovered in the venom of the Gila monster activates GLP-1 receptors and is now prescribed as a treatment for diabetes and obesity. Preclinical studies at the NIH showed that exenatide prevents neuronal damage and improves functional outcome in experimental models of Parkinson’s and Alzheimer’s diseases. Professor Tom Foltynie at University College London then led clinical trials of exenatide in Parkinson’s disease which demonstrated beneficial effects of exenatide. In this episode I talk with Professor Foltynie about GLP1 receptor agonists and how they protect neurons against damage and dysfunction in Parkinson’s and other neurological disorders. LINKS Professor Foltynie’s webpage: https://www.ucl.ac.uk/ion/research/our-departments/clinical-and-movement-neurosciences/people/prof-t-foltynie Lancet article: RCT of Exenatide in Parkinson’s disease: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5831666/pdf/nihms939356.pdf Review articles on GLP1 and its effects on diabetes and obesity https://www.cell.com/action/showPdf?pii=S1550-4131%2818%2930179-7 Review article on energy metabolism and Parkinson’s disease: https://content.iospress.com/download/journal-of-parkinsons-disease/jpd130335?id=journal-of-parkinsons-disease%2Fjpd130335 Preclinical studies of Exenatide for: Parkinson’s disease: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2633544/pdf/zpq1285.pdf Alzheimer’s disease: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2948479/ Huntington’s disease: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2628604/pdf/318.pdf

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Dr. Gillett, and James O'Hara discuss GLP1's and Sarms. Link to calculate your free testosterone: https://www.issam.ch/freetesto.htm 00:00 Intro 03:25 For minimal weight loss, GLP1 drugs may not be worth their risks. 11:05 SARMs are being explored as alternatives to GLP1s. 22:33 Bioidentical peptides show promise in boosting bone mass and reducing fat. 23:13 Kagraimma might benefit those nearing insulin dependency. 24:24 Misleading practices with research chemicals. 27:18 Using weaker GLP-1s first could aid sustainable weight management. 30:30 Peptide treatments should be paired with exercise and protein intake. 32:07 Pharma companies strategically time drug approvals. 34:26 Unethical medical practices advocating for value-based care. Studies/References: ► https://www.hollywoodreporter.com/lifestyle/lifestyle-news/microdosing-ozempic-weight-loss-health-gains-1236126989/ ► https://www.sciencedirect.com/science/article/abs/pii/S1094695018301987 ► https://pharmaphorum.com/news/novo-charts-course-ahead-cagrisema-after-lacklustre-data ► https://pmc.ncbi.nlm.nih.gov/articles/PMC8085567/ ► https://pmc.ncbi.nlm.nih.gov/articles/PMC3448920/ For High-quality labs: ► https://gilletthealth.com/order-lab-panels/ For information on the Gillett Health clinic, lab panels, and health coaching: ► https://GillettHealth.com Follow Gillett Health for more content from James and Kyle ► https://instagram.com/gilletthealth ► https://www.tiktok.com/@gilletthealth ► https://twitter.com/gilletthealth ► https://www.facebook.com/gilletthealth Follow Kyle Gillett, MD ► https://instagram.com/kylegillettmd Follow James O’Hara, NP ► https://Instagram.com/jamesoharanp For 10% off Gorilla Mind products including SIGMA: Use code “GH10” ► https://gorillamind.com/ For discounts on high-quality supplements ►https://www.thorne.com/u/GillettHealth #weightloss #glp1 #peptides #podcast #muscle