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How do we control satiation?
It is provided by a complex work of receptors in the gastrointestinal canal that feels it’s wall dilatation by the food masses and sends a signal to the brain to induce satiation and satiety. Intestinal endocrine L-cells are among the major parts of the gut-brain axis. These cells produce anorectic peptide hormones glucagon-like peptide-1 (GLP-1) and peptide YY (PYY) as a response to the food intake. This process is described in our short MoA medical animation video. GLP-1, when released into the bloodstream, affects pancreatic β-cells, which secrete insulin, a hormone that controls the glucose level; decreases gastric emptying; increases satiation. Furthermore, GI motility is reduced and food consumption decreased by PYY. L-cells also seems to have precise nutrient-perception receptors that is responsible for the direct detection of macronutrients. This mechanism takes place in pathways that control decreasing the appetite and raise energy outlay. The nutrient-perception mechanisms could be used as a basic principle for the discovery of medicines to manage obesity and metabolic disease.
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Journal access here: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10768757/#:~:text=More%20than%2075%25%20of%20the,unchanged%20or%20improved%20%5B28%5D.
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Ben Azadi is a podcaster, YouTuber and founder of Keto Kamp. Today on the show we discuss: Ben’s incredible life transformation story, the 5 golden rules for fat loss, the first step someone should take if they want to transform their health, tips for losing stubborn belly fat, small tweaks Ben has made recently that have improved his life, why he has changed his mind on counting calories and much more. Today's sponsor: LivOn Labs Get a FREE carton of Lypo-Spheric® B Complex Plus ($56 value) with any full-price purchase from https://www.livonlabs.com. This supplement has the B vitamins and minerals you need to turn food into sustained, natural energy throughout the day. Just add B Complex Plus and any other full-priced supplement to your cart and enter code BOPST24 at checkout. ⚠ WELLNESS DISCLAIMER ⚠ Please be advised; the topics related to health and mental health in my content are for informational, discussion, and entertainment purposes only. The content is not intended to be a substitute for professional advice, diagnosis, or treatment. Always seek the advice of your health or mental health professional or other qualified health provider with any questions you may have regarding your current condition. Never disregard professional advice or delay in seeking it because of something you have heard from your favorite creator, on social media, or shared within content you’ve consumed. If you are in crisis or you think you may have an emergency, call your doctor or 911 immediately. If you do not have a health professional who is able to assist you, use these resources to find help: Emergency Medical Services—911 If the situation is potentially life-threatening, get immediate emergency assistance by calling 911, available 24 hours a day. National Suicide Prevention Lifeline, 1-800-273-TALK (8255) or https://suicidepreventionlifeline.org. SAMHSA addiction and mental health treatment Referral Helpline, 1-877-SAMHSA7 (1-877-726-4727) and https://www.samhsa.gov
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