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GLP-1 Myths Busted: Desensitization, Damage, and Downregulation Explained
If you need assistance in your journey to reach your weight loss goals, book a consultation with me: https://calendly.com/drdanburton/weight-loss-consult
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Have you ever heard someone say that GLP-1 medications like Wegovy, Ozempic, or Zepbound stop working over time—or worse, that they damage your GLP-1 receptors? Some even suggest cycling off these medications to “reset” your system. Let me set the record straight.
In this video, I’m busting myths about desensitization, damage, and downregulation of GLP-1 receptors. I’ll walk you through the science of how these medications actually work, why they don’t “wear out” your receptors, and what real-world studies like SELECT and STEP 5 tell us. (Spoiler: these meds keep doing their job even when weight loss slows down.)
We’ll talk about the realities of weight-loss plateaus, how your body’s natural metabolic adaptations come into play, and why cycling off these meds might make it harder to reach or maintain your goals. I’ll also share why managing expectations is so important and how to navigate the noise from influencers and misinformation online.
Thanks for watching!
00:00 Introduction
00:40 GLP-1 Receptor Agonist Recap
01:34 Studies on desensitization or down-regulation
02:13 Dr. Dan’s Empowerment Hub
03:03 SELECT & STEP 5 Trials
04:45 Plateaus post-weight loss & grand expectations
06:24 So what’s going on?
08:11 Yesoul Fitness Bike - promo: DRDAN
09:11 Cycling medication & the Surmount 4 Trial
10:25 Yo-yo dieting
11:05 Final thoughts
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Watch my previous videos about how to fight obesity and about the best medicine for weight loss:
▪️ Food Noise: https://youtu.be/8qC2S638WBg
▪️ Watch This Before Taking Mounjaro: https://youtu.be/BmkVtGgejhk
▪️ From Ozempic to Mounjaro: https://youtu.be/L9e46iFWwIs
▪️ Muscle Loss with Ozempic, Wegovy & Mounjaro: https://youtu.be/lnEH-v64aG0
▪️ Managing Nausea from Ozempic, Wegovy and Trulicity!: https://youtu.be/3R1Fwhf02LE
▪️ Ozempic: Stomach Paralysis Update: https://youtu.be/MPyROywaM0g
▪️ How to Switch from Ozempic (or Wegovy) to Mounjaro: https://youtu.be/L9e46iFWwIs
▪️ Ozempic Paralyzed My Stomach: https://youtu.be/tj9thkkN5aM
▪️ How to Inject Mounjaro: step-by-step tutorial: https://youtu.be/piVHr7UqYDg
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Live in Alberta? Come see me at my Pharmacist-led Obesity Clinic at Apothecare Pharmacy - http://apothecarerx.ca
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Contact Me: [email protected]
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For more about weight loss via habit mastery, visit https://www.healthevolved.co
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Disclaimer of Medical Liability. HEALTHCARE EVOLUTION INC. DOES NOT PROVIDE MEDICAL ADVICE. The content of this material is for general informational purposes only. The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Reliance on any information provided here is solely at your own risk. Individual medical needs are very different; you should not assume that the information in this document concerning certain courses of treatment or outcomes will apply to you. Rather, you should evaluate your medical condition and make treatment decisions based upon consultation with your physician.
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Quit your sugar addiction and lose weight? It's possible and in this video I tell you the exact 3 steps I used to quit sugar and lose 70 pounds in 9 months.
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0:00 Intro
1:26 Step 1
3:22 Before/After Photos
4:21 Step 2
5:42 Step 3
7:18 116 Days Later...
8:10 How Quitting Sugar Impacts Weight Loss
9:01 How to Satisfy a Sweet Tooth
10:33 Discipline not Perfection
11:34 Mindset Shift
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Chrissy Metz’s Weight Loss Journey | Her Real Secret Will Surprise You!
Chrissy Metz, the beloved star of This Is Us, shocked the world with her dramatic weight loss. But how did she really do it?
In this video, we reveal Chrissy’s honest and inspiring journey — from struggling with body image to making simple, healthy lifestyle changes.
No crazy diets. No surgeries. Just real commitment and self-love.
Watch now to find out how she turned her life around — and how you can too!
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Hey girl, I hope you enjoyed this video! Make sure to hit my bell to stay updated on my weekly content. 🤍
Verse of the day
“Now may the God who gives endurance and encouragement grant you to live in harmony with one another, according to Christ Jesus,”
Romans 15:5
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The creator provides an update on their weight loss journey after eight weeks of semaglutide compound injections. They discuss noticing changes like face thinning, reduced inflammation, and feeling less swollen. This marks the first week where they can visually tell a difference and find that clothes fit better. The person expresses excitement, gratitude for their aesthetics team, and being on track to lose 50 pounds in six months without the overwhelming obsession usually associated with their past weight loss efforts.#weightlossjourney #semaglutide #inflammation #bodytransformation #healthupdate
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FTC | This video is sponsored by Naked Harvest! Some of the links provided are affiliate links. I earn a small commission off of each purchase, which allows me to invest back into my channel and purchase more products to review. All thoughts and opinions are my own! xx
FAQs
How old are you? 25
What camera do you use? Sony Zv-E10
How tall are you? 5ft" (152cm)
What nationality are you? Australian
Hi There!
My name is Conagh Kathleen and I am a 25 year old Australian! My channel is all about my passions in life! I have always wanted share my love of health and fitness, all things makeup and beauty with the world.
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Conagh Kathleen xx