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A board-certified practicing internal medicine physician talks about how your body regulates fat mass. It's a balance between building more fat (via an enzyme called lipoprotein lipase) and burning fat (facilitated by another enzyme called hormone sensitive lipase). When too much fat builds up, your body runs out of storage space and deposits the fat cells in organs like the liver. At this point, your fat cells start to go bad. They are consumed by adipose tissue macrophages which perpetuate a vicious cycle of inflammation and disease.
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