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The headlines about these drugs could give content every day. Here is the next big one. “PARALYZED STOMACHS!”
What they are saying is that a few people developed permanent gastroparesis from these new medicines (GLP-1 agonists eg wegovy or ozempic).
These drugs are known to slow down gastric emptying (how quickly your stomach digests). However, this effect usually decreases over time and what you’re left with is the satiety from the effect on the brain and not the nausea and bloating from your stomach being full.
This report is saying one or two people said they still had this feeling after stopping. We have no other history.
It’s possible these individuals had an underlying condition like type 2 diabetes where they already had gastroparesis. Hard to tell.
What I will say is that it’s not been seen in the trials and we haven’t encountered this in our 10s of thousands of patients at Sequence. If it does occur it would have to be extremely rare.
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As obesity rates continue to rise worldwide, researchers are constantly exploring new treatment options to help individuals achieve and maintain a healthy weight. One such medication that has gained attention in recent years is semaglutide, originally approved for the treatment of type 2 diabetes. However, studies have shown that semaglutide can also be effective for weight loss in non-diabetic individuals.
Understanding Semaglutide for Weight Loss
Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that works by mimicking the effects of a hormone that helps regulate blood sugar levels. When used for weight loss, semaglutide has been shown to reduce food intake by increasing feelings of fullness, slowing down digestion, and reducing hunger cravings. This can lead to significant weight loss in individuals who are struggling to lose weight through diet and exercise alone.
Studies have found that non-diabetic individuals who take semaglutide for weight loss can experience substantial reductions in body weight, body mass index (BMI), and waist circumference. These improvements in weight and body composition can have a positive impact on overall health, reducing the risk of obesity-related conditions such as heart disease, diabetes, and certain types of cancer.
It is important to note that semaglutide for weight loss is typically prescribed as part of a comprehensive weight management program that includes a reduced-calorie diet and increased physical activity. This medication is not intended for cosmetic weight loss or short-term use, but rather as a tool to help individuals make lasting lifestyle changes and improve their overall health.
Potential Side Effects of Semaglutide in Non-Diabetics
While semaglutide can be an effective weight loss tool, it is not without potential side effects. Some individuals may experience gastrointestinal symptoms such as nausea, vomiting, diarrhea, or constipation when taking semaglutide. These side effects are usually mild to moderate in severity and tend to improve over time as the body adjusts to the medication.
In rare cases, semaglutide can cause more serious side effects such as pancreatitis, gallbladder disease, or kidney problems. It is important for individuals taking semaglutide for weight loss to be aware of these potential risks and to talk to their healthcare provider if they experience any concerning symptoms. Regular monitoring and follow-up appointments with a healthcare provider are essential to ensure the safe and effective use of semaglutide.
Overall, semaglutide can be a valuable tool for weight loss in non-diabetic individuals, but it is important to weigh the potential benefits against the possible risks. By working closely with a healthcare provider and following a comprehensive weight management plan, individuals can achieve their weight loss goals in a safe and sustainable way.
FAQs About Semaglutide for Weight Loss
1. How does semaglutide work for weight loss in non-diabetic individuals?
Semaglutide works by increasing feelings of fullness, slowing down digestion, and reducing hunger cravings, leading to reduced food intake and weight loss.
2. What are the potential side effects of taking semaglutide for weight loss?
Potential side effects include gastrointestinal symptoms, pancreatitis, gallbladder disease, and kidney problems. It is important to talk to a healthcare provider if any concerning symptoms arise.
3. Is semaglutide safe for long-term use in non-diabetic individuals?
Long-term safety data is still being evaluated, but regular monitoring and follow-up appointments with a healthcare provider can help ensure the safe and effective use of semaglutide for weight loss.
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