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GLP-1 receptor agonists, initially developed for type 2 diabetes treatment, have shown remarkable benefits beyond blood glucose and weight control. Recent studies, including a comprehensive meta-analysis, demonstrate their significant impact on reducing major adverse cardiovascular events and slowing the progression of chronic kidney disease. These benefits extend to individuals with and without diabetes, suggesting a broader therapeutic potential. The cardiovascular and renal protective effects of GLP-1 receptor agonists appear to be independent of their glycemic and weight loss effects, possibly mediated by anti-inflammatory, anti-atherogenic, and vasodilatory mechanisms. As demand for these medications grows, challenges in equitable and sustainable implementation arise. Long-term use may be necessary to maintain health gains, and ensuring access for vulnerable populations is crucial to avoid worsening health disparities. Ongoing research into multi-receptor agonists may further expand the therapeutic potential of this drug class in cardiometabolic health.
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