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Welcome back to The Visser Podcast! 👋 Today, I’m diving deep into Retatrutide, often called the 'triple G' agonist, and why it's poised to be a game-changer in metabolic health and longevity. We're talking about the next frontier in weight management and beyond.
What is Retatrutide?
This groundbreaking compound targets three crucial hormones – GLP-1, GIP, and glucagon. This unique multi-hormonal approach has shown truly remarkable results, even surpassing current leading medications like tirzepatide and semaglutide in weight loss efficacy.
The Latest Clinical Insights:
In its Phase 2 trials, participants saw an average of 24.2% body weight reduction (that’s about 58 lbs!) over 48 weeks. Some even experienced up to 31% loss, which is quite significant and required careful dose management.
We're eagerly anticipating more data from the ongoing Phase 3 TRIUMPH program. Look out for results on obesity and OA knee studies coming in 2025, with further insights into obstructive sleep apnea (OSA) and type 2 diabetes expected by mid-2026. Plus, we'll see Phase 2b renal function trial results in Q4 2025.
Safety & What We Know So Far:
Like many medications in this class, common side effects include nausea and abdominal pain. The rapid weight loss observed means careful dosing is key, with some participants needing to increase caloric intake to stabilize weight. We did see one reported case of kidney stones, though its direct link to the drug is still being investigated.
Beyond Weight Loss: The Broader Benefits:
What truly excites me are the potential benefits beyond just weight loss. Early data suggests significant improvements in comorbidities like reduced knee pain, better cholesterol levels, and even improved fatty liver disease. There's promising data pointing to liver fat reduction and potential benefits for MASH (metabolic dysfunction-associated steatohepatitis).
The Competitive Edge:
Retatrutide could really solidify Eli Lilly's leadership in obesity therapeutics, potentially offering a new solution for those who haven't responded to existing therapies. It's an exciting time with new innovations like oral GLP-1 pills and once-yearly shots also in the pipeline.
Key Upcoming Milestones:
2025: Phase 3 obesity/OA knee data release.
2026: Full Phase 3 results (TRIUMPH-1/-2) and potential FDA submission.
2027: Head-to-head trial vs. tirzepatide (TRIUMPH-5).
This medication represents a significant step forward in our journey toward better health and longevity. I'll keep you updated as more data emerges!
Let me know your thoughts and questions in the comments below! 👇
Relevant Studies & Resources:
https://doi.org/10.1093/ehjcvp/pvad080
https://www.novonordisk.com/news-and-media/news-and-ir-materials/news-details.html?id=915087
https://sciencehub.novonordisk.com/content/dam/sciencehub/global/en/congresses-and-scientific-publications/congresses/ow2024/Garvey/documents/Garvey_OASIS_4_OW24-oral_Final_23Oct24.pdf
https://doi.org/10.1001/jamainternmed.2024.2525
https://investor.lilly.com/news-releases/news-release-details/lillys-tirzepatide-successful-phase-3-study-showing-benefit
https://investor.lilly.com/news-releases/news-release-details/lillys-tirzepatide-was-superior-placebo-mash-resolution-and-more
https://investor.lilly.com/news-releases/news-release-details/lillys-phase-2-retatrutide-results-published-new-england-journal
https://www.boehringer-ingelheim.com/human-health/metabolic-diseases/survodutide-top-line-results-mash-fibrosis
https://ir.altimmune.com/news-releases/news-release-details/correction-altimmune-presents-results-phase-2-mri-based-body
https://investors.amgen.com/static-files/0176d78e-920b-45b3-b9cc-a727e58e80da
https://investor.lilly.com/news-releases/news-release-details/lillys-phase-2-results-published-new-england-journal-medicine
https://ir.vikingtherapeutics.com/2024-11-04-Viking-Therapeutics-Reports-New-Data-from-VK2735-Obesity-Program-at-ObesityWeek-R-2024
https://www.novonordisk.com/news-and-media/news-and-ir-materials/news-details.html?id=915082
https://www.novonordisk.com/news-and-media/news-and-ir-materials/news-details.html?id=915251
https://medically.roche.com/global/en/medical-material.3d8d7ba5-5a5d-4b7d-bed7-f4f5e05e5a6e.qr.html?cid
https://www.kailera.com/press-release/jiangsu-hengrui-pharmaceuticals-and-kailera-therapeutics-report-positive-topline-data-from-8-mg-dose-of-phase-2-obesity-trial-of-glp-1-gip-receptor-dual-agonist-hrs9531/
Pharmaceuticals Vs Nutraceuticals In Weight Loss
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Welcome to our detailed video focusing exclusively on the core components that make up the popular supplement, Java Burn. Today, we're diving deep into the world of java burn coffee ingredients, exploring what they are and how each plays a crucial role in the formula. Understanding the specific java burn coffee ingredients is key to grasping how this product is designed to work. We aim to provide a comprehensive overview of the various java burn coffee ingredients you might find in this unique blend, shedding light on their individual benefits and collective synergy.
The search for effective weight management solutions often leads to supplements, and Java Burn has gained significant attention. A primary reason for this interest lies in its carefully selected java burn coffee ingredients. Unlike many standard dietary aids, the thoughtful combination of java burn coffee ingredients is what sets it apart. These java burn coffee ingredients are chosen for their purported abilities to support metabolism and aid in fat burning. Each of the java burn coffee ingredients contributes to a multi-faceted approach to wellness, particularly around energy and metabolic processes. Knowing more about these java burn coffee ingredients empowers you with knowledge about what you're consuming.
One of the main areas where Java Burn's potential lies is in metabolism boosting, and this effectiveness is directly attributable to the specific java burn coffee ingredients. Your body’s metabolism is essentially the engine that converts food into energy. Certain java burn coffee ingredients, like green tea extract and caffeine, are widely recognized for their metabolic support. By including these powerful java burn coffee ingredients, the formula aims to enhance the rate at which your body burns calories, which is a fundamental aspect of weight management. We will explore each of these metabolic-boosting java burn coffee ingredients in detail.
Furthermore, the discussion around java burn coffee ingredients often highlights their role in fat reduction. The chosen blend of java burn coffee ingredients is designed to target stubborn fat stores within the body. Ingredients such as L-Carnitine and chromium picolinate, commonly found in weight management formulas, are believed to support the breakdown of fat cells, making them more available for energy conversion. It’s the precise combination of these fat-targeting java burn coffee ingredients that defines the product’s approach to body composition support. The synergistic effect of these java burn coffee ingredients is continuously discussed by users and researchers alike.
Java Burn’s strategy for weight management is often described as a two-pronged approach, entirely dependent on its unique java burn coffee ingredients. Firstly, by leveraging specific java burn coffee ingredients like natural stimulants and thermogenics, it seeks to elevate metabolic rates, leading to increased calorie expenditure. Secondly, other java burn coffee ingredients are included with the goal of curbing cravings and promoting better appetite control. This dual action, facilitated by a comprehensive set of java burn coffee ingredients, contributes to managing calorie intake and promoting a more sustainable path to weight goals. Understanding this approach helps in appreciating the complexity of the java burn coffee ingredients.
Now, let's delve deeper into the key java burn coffee ingredients that are often associated with this supplement. While the exact blend can vary, common categories of java burn coffee ingredients include powerful antioxidants, metabolism enhancers, and appetite modulators. For instance, Green Tea Extract, rich in EGCG, is a popular java burn coffee ingredient known for its antioxidant properties and supposed metabolic boost. Another frequently cited java burn coffee ingredient is Caffeine, a well-known stimulant that can enhance energy and fat oxidation. L-Theanine, often paired with caffeine, is another one of the intriguing java burn coffee ingredients, promoting calm focus without jitters. Chromium Picolinate, a mineral listed among the potential java burn coffee ingredients, is often included for its role in carbohydrate and fat metabolism. Furthermore, L-Carnitine, a natural amino acid, is sometimes featured as a java burn coffee ingredient for its role in transporting fatty acids into cells for energy. The inclusion of Chlorogenic Acid from green coffee bean extract is also a notable point when discussing the comprehensive list of java burn coffee ingredients, as it's linked to glucose metabolism. These specific java burn coffee ingredients work in concert, creating a holistic strategy for metabolic support and fat ma
Shark Tank Episode About Keto Detailed Recap And Analysis
As the popularity of the ketogenic diet continues to rise, more and more people are looking for ways to incorporate keto-friendly snacks and supplements into their daily routine. One product that has been gaining traction in the keto community is XP Nutrition Keto Gummies. These gummies are designed to provide a convenient and delicious way to support a ketogenic lifestyle, making it easier to stay on track with your diet goals.
Benefits of XP Nutrition Keto Gummies
XP Nutrition Keto Gummies are made with high-quality ingredients that are specifically chosen to support a keto diet. These gummies are low in carbohydrates and sugar, making them a perfect snack for those following a ketogenic lifestyle. In addition, they are packed with essential nutrients and antioxidants that can help support overall health and well-being.
One of the main benefits of XP Nutrition Keto Gummies is that they can help curb cravings and keep you feeling satisfied between meals. This can be especially helpful for those who struggle with hunger pangs while on a keto diet, as the gummies can provide a quick and easy way to satisfy your sweet tooth without derailing your progress.
Another benefit of XP Nutrition Keto Gummies is that they are convenient and portable, making them a great option for those who are on the go. Whether you’re heading to work, the gym, or traveling, these gummies can easily be taken with you wherever you need to go. This makes it easier to stick to your keto diet no matter where life takes you.
User Reviews of XP Nutrition Keto Gummies
Many users who have tried XP Nutrition Keto Gummies have reported positive results and experiences. Some users have noted that the gummies helped them stay on track with their keto diet by providing a tasty and satisfying snack option. Others have mentioned that the gummies helped them curb their cravings for sugary treats, making it easier to stick to their dietary goals.
Some users have also reported feeling more energized and focused after incorporating XP Nutrition Keto Gummies into their daily routine. This could be due to the blend of vitamins and minerals in the gummies that support overall health and well-being. Overall, the majority of user reviews for XP Nutrition Keto Gummies have been positive, with many users praising the taste and effectiveness of the product.
It’s important to note that individual results may vary, and it’s always best to consult with a healthcare professional before making any changes to your diet or supplement routine. Additionally, it’s recommended to follow a balanced diet and exercise regularly while using XP Nutrition Keto Gummies for optimal results.
FAQs About XP Nutrition Keto Gummies
1. Are XP Nutrition Keto Gummies safe to use on a keto diet?
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Yes, XP Nutrition Keto Gummies are specifically formulated to support a ketogenic lifestyle and are made with ingredients that are compatible with a low-carb, high-fat diet.
2. How many gummies should I take per day?
The recommended dosage of XP Nutrition Keto Gummies may vary depending on your individual needs and goals. It’s best to follow the instructions on the product packaging or consult with a healthcare professional for personalized guidance.
3. Can XP Nutrition Keto Gummies help with weight loss?
While XP Nutrition Keto Gummies can be a helpful tool for those looking to support their keto diet, it’s important to remember that they are not a magic solution for weight loss. A balanced diet, regular exercise, and overall healthy lifestyle choices are key factors in achieving and maintaining weight loss goals.
Ozempic A New Treatment For Weight Loss Does It Work
Lindsey Reiser reports on the fatal mass shooting at Florida State University, the possibility of a new drug for diabetes and weight loss, and what the California attorney general has to say about the state's lawsuit over the Trump administration’s sweeping tariffs.
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New Weight Loss Drug Could Break Sales Records
In this episode of The Mic Spot, we dive deep into the rising debate surrounding weight loss drugs like Ozempic, Wegovy, and Mounjaro. While these GLP-1 agonist medications have been marketed as groundbreaking solutions for weight loss, a recent study reveals a surprising truth: after two years of use, overall healthcare costs actually increase. We explore why these drugs, despite their potential to help individuals lose weight, might not be the cost-saving solution we initially expected.
Join us as we break down the financial and healthcare implications, discuss the temporary nature of weight loss, and explore the high costs of these medications. Plus, we'll look at the need for further research to assess their long-term efficacy and cost-effectiveness. Tune in for expert insights and thought-provoking conversation.
This episode is based on Finshots’ analysis, a financial news publication. And stay tuned for some exciting updates about Finshots and Ditto in the coming weeks!
Don’t forget to like, share, and subscribe for more insightful episodes on healthcare, economics, and everything in between!
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Top 5 Best Weight Loss Supplement In 2024
Are you looking for a new way to support your ketogenic lifestyle? Look no further than Goxtra ACV Keto Gummies! These gummies provide a convenient and tasty twist on traditional ketogenic support. With a unique combination of ingredients, including apple cider vinegar (ACV) and exogenous ketones, these gummies can help you stay on track with your keto goals while satisfying your sweet tooth.
Five Key Features of Goxtra ACV Keto Gummies
Goxtra ACV Keto Gummies are packed with key ingredients that can help support your ketogenic lifestyle. Here are five features that make these gummies stand out:
1. Apple Cider Vinegar (ACV): ACV is known for its potential health benefits, including aiding in digestion and weight management. By adding ACV to these gummies, you can enjoy the benefits of this powerful ingredient in a delicious and convenient form.
2. Exogenous Ketones: Exogenous ketones can help your body enter ketosis more quickly, making it easier to stay in this fat-burning state. Goxtra ACV Keto Gummies contain exogenous ketones to support your keto journey.
3. Low Carb and Sugar-Free: These gummies are low in carbs and sugar-free, making them a keto-friendly option for satisfying your cravings. You can enjoy a sweet treat without derailing your ketogenic diet.
How to Incorporate Goxtra ACV Keto Gummies Into Your Routine
There are many ways to incorporate Goxtra ACV Keto Gummies into your daily routine. Here are three suggestions for how to make the most of these tasty gummies:
1. Snack on them between meals: Goxtra ACV Keto Gummies can be a great snack option when you need a little pick-me-up between meals. Keep a pack handy for a quick and convenient way to satisfy your sweet tooth.
2. Add them to your pre-workout routine: If you need a boost before hitting the gym, try incorporating Goxtra ACV Keto Gummies into your pre-workout routine. The exogenous ketones in these gummies can help fuel your workout and support your fitness goals.
3. Include them in your post-meal ritual: After a satisfying meal, treat yourself to a few Goxtra ACV Keto Gummies as a dessert alternative. These gummies can help curb your sweet cravings while staying true to your ketogenic lifestyle.
Benefits of Using Goxtra ACV Keto Gummies
There are many benefits to using Goxtra ACV Keto Gummies as part of your ketogenic routine. Here are three reasons why you should consider adding these gummies to your daily regimen:
1. Convenience: Goxtra ACV Keto Gummies are easy to take on the go, making them a convenient option for busy lifestyles. You can enjoy the benefits of ACV and exogenous ketones without any hassle.
2. Delicious Taste: These gummies come in a delicious flavor that can satisfy your sweet cravings without the guilt. Say goodbye to bland supplements and hello to a tasty treat that supports your keto goals.
3. Support for Ketosis: By incorporating Goxtra ACV Keto Gummies into your routine, you can support your body’s natural ketosis process. The combination of ACV and exogenous ketones can help keep you on track with your ketogenic lifestyle.
FAQ about Goxtra ACV Keto Gummies
1. Are Goxtra ACV Keto Gummies suitable for all diets?
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Yes, Goxtra ACV Keto Gummies are suitable for a ketogenic lifestyle as they are low in carbs and sugar-free. However, it’s always best to consult with a healthcare professional before adding any new supplement to your routine.
2. How many gummies should I take per day?
The recommended dosage of Goxtra ACV Keto Gummies may vary, so it’s essential to follow the instructions on the product label. Typically, a serving size is 2-3 gummies per day, but individual needs may differ.
3. Can I take Goxtra ACV Keto Gummies with other supplements?
While Goxtra ACV Keto Gummies can be taken on their own, they can also be used in conjunction with other supplements. If you have any concerns about potential interactions, consult with a healthcare professional before combining supplements.
