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I am almost 11 years post vsg surgery and had glp-1 medications been an option in 2014 I don’t know if I would’ve gone through with the surgery #glp1 #pcos #tirzepatide #vsg
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Apports des agonistes du récepteur du GLP-1 (GLP1-RA) dans le traitement du diabète et la protection cardiovasculaire par le Pr B. Charbonnel. Le Pr. Charbonnel a d’abord rappelé que le diabète était avant tout une maladie vasculaire, avec des complications à la fois microvasculaires (rétinopathie, neuropathie, néphropathie) et macrovasculaires (cardiaques) et qu’un bon contrôle glycémique (valeur cible d’HbA1C ≤7%) permettait de réduire ces complications (surtout microvasculaires). A côté des antidiabétiques classiques, une nouvelle classe de médicaments, les incrétines, permet d’atteindre cette cible : il s’agit des agonistes du récepteur du GLP-1 (glucagon-like peptide-1). Le GLP-1 est une hormone digestive, produite au moment des repas, qui stimule l’insuline et freine le glucagon. Donnée d’importance, son action est glucorégulée, ç.à.d. que lorsque la glycémie approche de la normale, cette hormone n’est plus stimulée, ce qui évite le risque d’hypoglycémie. Il existe deux approches pharmacologiques pour augmenter le GLP-1 : soit maintenir le taux de GLP-1 endogène en recourant à des inhibiteurs de sa dégradation enzymatique, soit remplacer l’hormone par des agonistes du récepteur de GLP-1 (GLP-1 RA). Deux principaux agonistes : le liraglutide (commercialisé en France) qui agit sur environ 24 heures et requiert donc une injection sous-cutanée quotidienne, et le dulaglutide qui agit sur plus d’une semaine. A côté de leur efficacité hyplogycémiante puissante, ces composés entraînent une perte pondérale. Ils sont globalement bien tolérés (troubles digestifs dans 20% des cas). Mais outre un antidiabétique, le GLP-1-RA est aussi un protecteur cardiovasculaire, ainsi qu’il a été démontré pour le liraglutide par l’étude LEADER portant sur 9340 patients atteints d’un diabète de type 2. Le mécanisme de cet effet reste à élucider. Il est possible qu’à côté d’une sommation de bénéfices métaboliques (réduction de la glycémie, du poids, de la tension artérielle), le GLP-1 exerce une action directement vasculaire. Ainsi émerge aujourd’hui un nouveau paradigme pour lutter contre les complications du diabète de type 2 : non seulement réduire l’hyperglycémie mais recourir à des médicaments antidiabétiques ayant démontré un bénéfice cardiovasculaire dont le liraglutide. Retrouvez l'intégralité de la séance ➡️ http://www.academie-medecine.fr/seance-commune-du-10-avril-2018-des-commissions-therapeutique-pharmacologie-toxicologie-medicaments-et-autres-produits-de-sante-et-maladies-cardiovasculaires-et-appareil-digestif-nutrit/ Et suivez l'actualité de l'Académie nationale de médecine sur TWITTER : @acadmed
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📉 Shocking drop: Novo Nordisk shares plummet 21.8% to $53.98 amid obesity drug market downturn 💸 Sales and profit guidance slashed for 2025 due to competition from cheaper compounded knockoffs of Wegovy 🌎 New leadership: Maziar Mike Doustdar, former international operations head, takes over as CEO 💰 Q2 earnings better than expected at 5.96 DKK per share, but guidance cuts significant (8-14% sales growth, 10-16% operating profit growth) 🛢 Future challenges: Increasing competition & compounding concerns in the weight-loss drug market 🔄 Focus on improving commercial execution and cutting costs for incoming CEO Doustdar 💡 Remains optimistic about Novo's position, emphasizing manufacturing capabilities, science, commercial activities, and brand recognition as key strengths. #NovoNordisk #StockDrop #ObesityDrugMarket #Wegovy #CEOChange #MaziarMikeDoustdar #LarsFruergaardJorgensen #CompoundedGLP1Drugs #MarketCrowding #TelehealthPharmacies #WeightLossDrugIndustry #CostCutting#ABRMARKETWATCH
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This video is not medical advice. Are you on it for life?- video here.... https://youtu.be/LOAuEh8Y0oQ If you are overweight and feel the way you eat is problematic in itself- there are eating disorders that cause obesity- and trying to diet your weight out of them can be counter productive and extremely unpleasant. Whilst you might feel desperate to lose the weight- and like happiness is just at the end of that- the benefits to overcoming an eating disorder can be just as like changing on their own- in fact much more so. It can be hard to speak to a doctor about eating disorders when you are overweight but don't be afraid to do it- and start some research at https://www.beateatingdisorders.org.uk Instagram: www.instagram.com/dremmaanders My business: www.Vantageagendas.com IG: https://www.instagram.com/vantageagendas/ TikTok: https://www.tiktok.com/@vantage_agendas I use affiliate links.