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Lose Weight Eating Garlic Butter Chicken #weightlossmeals #eatclean #highprotein
Disclaimer:
All content on Eat & Drink to Lose is for informational purposes only. It is not medical advice. Always consult a healthcare professional before making any changes to your diet, lifestyle, or health routine.
Time stamps
0:30 what are ketones
The 3 ketone bodies are acetone, acetoacetate and beta hydroxybutyrate
Your liver makes ketones from acetyl-CoA
1:02 why does breath smell weird on keto (keto breath)
1:43 what is beta hydroxybutyrate (the best ketone for brain health)
1:55 how are ketones made (ketogenesis)
Ketogenesis is the pathway that makes ketones, ketogenesis happens in your liver only
Long chain fatty acids are oxidized in the mitochondria to yield acetyl-CoA (beta oxidation)
In a ketogenic state / keto metabolic state the acetyl-coa is favourably directed into ketogenesis instead of the tricarboxylic acid / citric acid cycle
Under normal conditions (normal carbohydrate diet / fed) the long chain fatty acids are oxidized to acetyl-coa and the acetyl-coa will then enter the tricarboxylic acid / citric acid cycle
In starvation states or proper keto diets, if the TCA cycle is slowed or deplete of intermediates then the acetyl-coa enters ketogenesis
Ketogenesis should only happen in extreme starvation or on true keto diets
3:13 ketogenic pathway biochemistry
Enzymes essential to ketogenesis…
Thiolase, HMG-CoA synthase, HMG-CoA lyase, acetoacetate decarboxylase, betahydroxybutyrate dehydrogenase
4:47 acetoacetate can be cleaved to give CO2, acetone and betahydroxybutyrate
5:37 what is BHB
6:46 how do ketones give you energy (metabolism basics)
Acetyl-coa is the common entry point to the tricarboxylic acid / citric acid cycle - glucose, fatty acids and amino acids can all be metabolized into ACoA
ACoA can enter the TCA cycle for complete oxidation and to yield large amounts of energy
Ketogenesis is when you make ketones from ACoA in the liver, the ketones then enter circulation, travel to the brain where they are converted back into ACoA, now in your brain the ACoA enters the TCA cycle for complete and rapid oxidation thus yielding large amounts of energy
9:02 How to get into ketosis / when are you in ketosis
9:37 what happens when you are starving
10:39 what is keto diet
Keto diet macro distribution
5% calories from carbohydrate
25% calories from protein
70% calories from fat
11:12 why is starvation bad for you (protein sparing effect / TCA cycle depletion)
11:59 long term fasting / prolonged fasting diets
13:40 ketosis acidifies your blood and damages organs (ketoacidosis)
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Can a Ketogenic Diet Help Treat Parkinson’s Disease? Speaking as someone who completed his PhD on this topic, my answer is “Yes.” In this video, I’ll break down why I believe this is the case, review the mechanistic science and human trials, and share insights on how you can start a ketogenic diet today, whether you have Parkinson’s or not.
Chapters
0:00 – A Ketogenic Diet for Parkinson’s Disease
1:12 – What is Parkinson’s Disease?
2:24 – How Common is Parkinson’s Disease?
3:10 – Why this video, now? My background.
5:32 – What Causes Parkinson’s Disease?
8:14 – Ketogenic Diet Holds Hope for Parkinson’s Disease
9:30 – Mechanism 1. Ketogenic diet and Brain Energy
10:45 – Mechanism 2. Sneaking in the Energetic Backdoor
12:04 – Mechanism 3. Enhancing Antioxidant Defenses
13:08 – Mechanism 4. Boosting Dopamine Synthesis
14:23 – Human Trials for Keto in Parkinson’s
16:08 – Slowing or Stopping Disease Progression
18:04 – Personal Patient Example
19:21 – How to do a Ketogenic Diet for Parkinson’s disease
Norwitz et al. References
Ketones for Parkinson’s Disease Review: https://pubmed.ncbi.nlm.nih.gov/31139630/
Exercise Randomized Controlled Trial: https://pubmed.ncbi.nlm.nih.gov/33100965/
Neuroketotherapeutics Textbook Chapter: https://pubmed.ncbi.nlm.nih.gov/32854853/
#parkinsonsdisease #brainenergy #ketodiet #dopamine #neuroscience #ketones #brainhealth #metabolism #staycurious
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