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Apports des agonistes du récepteur du GLP-1 (GLP1-RA) dans le traitement du diabÚte et la protection cardiovasculaire par le Pr B. Charbonnel.
Le Pr. Charbonnel a dâabord rappelĂ© que le diabĂšte Ă©tait avant tout une maladie vasculaire, avec des complications Ă la fois microvasculaires (rĂ©tinopathie, neuropathie, nĂ©phropathie) et macrovasculaires (cardiaques) et quâun bon contrĂŽle glycĂ©mique (valeur cible dâHbA1C â€7%) permettait de rĂ©duire ces complications (surtout microvasculaires).
A cĂŽtĂ© des antidiabĂ©tiques classiques, une nouvelle classe de mĂ©dicaments, les incrĂ©tines, permet dâatteindre cette cible : il sâagit des agonistes du rĂ©cepteur du GLP-1 (glucagon-like peptide-1).
Le GLP-1 est une hormone digestive, produite au moment des repas, qui stimule lâinsuline et freine le glucagon. DonnĂ©e dâimportance, son action est glucorĂ©gulĂ©e, ç.Ă .d. que lorsque la glycĂ©mie approche de la normale, cette hormone nâest plus stimulĂ©e, ce qui Ă©vite le risque dâhypoglycĂ©mie. Il existe deux approches pharmacologiques pour augmenter le GLP-1 : soit maintenir le taux de GLP-1 endogĂšne en recourant Ă des inhibiteurs de sa dĂ©gradation enzymatique, soit remplacer lâhormone par des agonistes du rĂ©cepteur de GLP-1 (GLP-1 RA). Deux principaux agonistes : le liraglutide (commercialisĂ© en France) qui agit sur environ 24 heures et requiert donc une injection sous-cutanĂ©e quotidienne, et le dulaglutide qui agit sur plus dâune semaine. A cĂŽtĂ© de leur efficacitĂ© hyplogycĂ©miante puissante, ces composĂ©s entraĂźnent une perte pondĂ©rale. Ils sont globalement bien tolĂ©rĂ©s (troubles digestifs dans 20% des cas). Mais outre un antidiabĂ©tique, le GLP-1-RA est aussi un protecteur cardiovasculaire, ainsi quâil a Ă©tĂ© dĂ©montrĂ© pour le liraglutide par lâĂ©tude LEADER portant sur 9340 patients atteints dâun diabĂšte de type 2. Le mĂ©canisme de cet effet reste Ă Ă©lucider. Il est possible quâĂ cĂŽtĂ© dâune sommation de bĂ©nĂ©fices mĂ©taboliques (rĂ©duction de la glycĂ©mie, du poids, de la tension artĂ©rielle), le GLP-1 exerce une action directement vasculaire. Ainsi Ă©merge aujourdâhui un nouveau paradigme pour lutter contre les complications du diabĂšte de type 2 : non seulement rĂ©duire lâhyperglycĂ©mie mais recourir Ă des mĂ©dicaments antidiabĂ©tiques ayant dĂ©montrĂ© un bĂ©nĂ©fice cardiovasculaire dont le liraglutide.
Retrouvez l'intégralité de la séance
âĄïž http://www.academie-medecine.fr/seance-commune-du-10-avril-2018-des-commissions-therapeutique-pharmacologie-toxicologie-medicaments-et-autres-produits-de-sante-et-maladies-cardiovasculaires-et-appareil-digestif-nutrit/
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Tasha Cobbs is a renowned gospel singer who has captivated audiences with her powerful voice and inspiring lyrics. In addition to her music career, Tasha Cobbs is also a health enthusiast who has recently launched a new supplement called Tasha Cobbs Keto Gummies. These gummies are designed to support weight management and help individuals achieve their health goals in a natural and sustainable way.
Benefits of Tasha Cobbs Keto Gummies
One of the key benefits of Tasha Cobbs Keto Gummies is their ability to promote weight management. These gummies are formulated with ingredients that are known to support fat burning and metabolism, making them an ideal supplement for individuals looking to shed excess pounds. In addition, the gummies are easy to incorporate into your daily routine, making it convenient to take them on the go.
Another benefit of Tasha Cobbs Keto Gummies is that they are made with all-natural ingredients. This means that you can feel confident about what you are putting into your body, without having to worry about any harmful chemicals or additives. The gummies are also free from artificial flavors and colors, making them a safe and healthy choice for anyone looking to support their weight management goals.
Furthermore, Tasha Cobbs Keto Gummies are designed to help curb cravings and reduce appetite. This can be especially helpful for individuals who struggle with overeating or snacking throughout the day. By taking these gummies as directed, you can help regulate your hunger levels and make it easier to stick to your weight loss plan.
Ingredients in Tasha Cobbs Keto Gummies
The ingredients in Tasha Cobbs Keto Gummies are carefully selected to support weight management and overall health. One key ingredient in these gummies is Garcinia Cambogia, a fruit that is known for its ability to suppress appetite and block the production of fat. This can help individuals control their calorie intake and prevent weight gain.
Another important ingredient in Tasha Cobbs Keto Gummies is Green Tea Extract, which is rich in antioxidants that can help boost metabolism and promote fat burning. Green tea has also been shown to improve brain function and reduce the risk of certain diseases, making it a valuable addition to these gummies.
Additionally, Tasha Cobbs Keto Gummies contain Apple Cider Vinegar, which has been linked to numerous health benefits, including weight loss and improved digestion. This ingredient can help regulate blood sugar levels and promote feelings of fullness, making it easier to stick to your weight management plan.
How to Use Tasha Cobbs Keto Gummies
To experience the full benefits of Tasha Cobbs Keto Gummies, it is recommended to take two gummies daily. Simply chew the gummies before or after a meal, depending on your preference. It is important to follow the recommended dosage and not exceed the stated amount, as this can affect the effectiveness of the supplement.
For best results, it is also recommended to incorporate a healthy diet and regular exercise routine while taking Tasha Cobbs Keto Gummies. This will help maximize the effects of the supplement and support your overall health and wellness goals. Remember that supplements are just that â a supplement to a healthy lifestyle, and should not be relied upon as a sole solution for weight management.
Before starting any new supplement regimen, it is always a good idea to consult with your healthcare provider to ensure that the supplement is safe for you to take, especially if you have any underlying health conditions or are taking medication that may interact with the ingredients in the gummies.
Final Thoughts on Tasha Cobbs Keto Gummies
In conclusion, Tasha Cobbs Keto Gummies can be a helpful tool for individuals looking to support their weight management goals in a natural and effective way. With their carefully selected ingredients and proven benefits, these gummies can help curb cravings, boost metabolism, and promote fat burning, making it easier to achieve your desired results.
Remember that consistency is key when it comes to any supplement regimen, so be sure to take your Tasha Cobbs Keto Gummies as directed and stick to a healthy lifestyle to maximize their benefits. With dedication and commitment, you can reach your weight management goals and feel confident in your body once again.
If you are interested in trying Tasha Cobbs Keto Gummies for yourself, be sure to visit the official website to learn more about this supplement and how it can help you on your health and wellness journey. Take the first step towards a healthier you today with Tasha Cobbs Keto Gummies!
Supplements ONLY work if YOU doâŠ
I used to think fat burners were the missing piece. But after losing 110 pounds and cutting 20 in just six weeks, I realizedâŠ
No pill beats consistency.
99% of your fat loss success comes from habits, not bottles.
Here are 3 that outperform any supplement:
1ïžâŁ Track Food Daily â Not weekly. Not âwhen I remember.â DAILY. This builds the awareness needed to stay in a deficit.
2ïžâŁ Get 10K+ Steps/Day â Movement burns calories. And you donât even need a gym. Just walk.
3ïžâŁ Own Your Weekends â Most people cheat Friday through Sunday. Stay consistent when others quit, and youâll separate yourself fast.
Discipline is the real fat burner.
DM me or Comment â2025â for my FREE fat loss guide
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I Tried The World's Most Expensive Diet
Topics: diet, grocery haul, erewhon, fitness, bodybuilding, worlds most expensive diet, review, food review, mukbang, taste test, cheap vs expensive
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In this episode of Bulletproof Mindset, we're diving into the signs that show you're losing body fat without losing muscle. If you've ever wondered how to tell if your fat loss journey is on the right track, this one's for you!
I share what to look for, plus tips to keep muscle while shedding those extra pounds. Whether you're just starting out or looking to fine-tune your approach, we've got you covered.
And if you are interested in the Bulletproof Coaching Starting Strong Programme:
https://www.bulletproofcoaching.co.uk/strong-programme
Tune in and let's get you feeling great about your progress!
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