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I finally get around to giving a metformin update for my PCOS and I talke about trying ozempic for weight loss and what I am planning to lose weight. I give an update to how I am feeling about my weight loss journey and about my anxiety and mental health.

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Click Here to Subscribe: http://Bit.ly/ThomasVid Get MY Recommendation on Groceries Delivered to Your Doorstep with Thrive Market: http://ThriveMarket.com/ThomasDeLauer This video does contain a paid partnership with a brand that helps to support this channel. It is because of brands like this that we are able to provide the content that we do for free. The best way that you can directly support my channel, is by supporting the brands that help make this all possible. Any product that you see on my channel is a product that I also use personally, regardless of any paid promotion. Get my Free Newsletter and Downloadable Cheatsheets (eating out, travel, etc): https://www.thomasdelauer.com/life-optimization-tactics/ Follow More of My Daily Life on Instagram: http://www.Instagram.com/ThomasDeLauer It's important that I am honest and to say that this video does have a sponsorship from Thrive Market, supporting them is a good way to support my channel! Insulin-Mediated Glucose Uptake The molecular mechanisms of insulin-mediated glucose transport are intensively studied - GLUT4 (glucose transporter type 4) is a glucose transporter responsible for glucose uptake into adipocytes and muscle tissue Importantly, in case of insulin resistance and type-2, the amount of GLUT4 is decreased and its translocation is impaired https://www.hindawi.com/journals/omcl/2019/3849692/ Insulin resistance is characterized by inefficient mitochondrial coupling, low level of ATP, and the formation of excess amount of ROS A study published in The Journal of Cachexia, Sarcopenia and Muscle, shows that astaxanthin stimulates mitochondrial biogenesis in insulin resistant muscle via activation of AMPK pathway* https://onlinelibrary.wiley.com/doi/full/10.1002/jcsm.12530 Astaxanthin Astaxanthin accumulation in skeletal muscle has been shown to reduce hyperglycemia and ameliorate insulin secretion and sensitivity by improvement of glucose metabolism and β-cell dysfunction by GLUT4 regulation Astaxanthin administration increases the translocation of GLUT4 transporter and PGC-1α, which increases the level of GLUT4 Study - Asia Pacific Clinical Nutrition This double blind, randomized, placebo controlled study included 41 patients ranging from 30 to 60 years of age with type 2 diabetes who were not on insulin therapy. Each patient consumed 8 mg of astaxanthin or placebo daily for 8 weeks. As a result, the astaxanthin group demonstrated an increase in adiponectin concentration and reduced visceral body fat, triglycerides, LDL cholesterol, and systolic blood pressure. https://www.ncbi.nlm.nih.gov/pubmed/29384321 https://www.ncbi.nlm.nih.gov/pubmed/12688512 Zinc Zinc ions can bind to insulin receptors and activate insulin signaling pathways Believed that zinc ions inhibit glycogen synthase kinase-3beta (GSK-3beta), serine/threonine protein kinase linked with insulin resistance and type 2 diabetes https://www.ncbi.nlm.nih.gov/pubmed/12083774 Study - Journal of Diabetes After a year, 25% of the placebo group developed type 2 diabetes and of the zinc group, 11 percent developed type 2 diabetes. The zinc group also had a lower fasting plasma glucose, oral glucose tolerance test, homeostatic model assessment of insulin resistance as well as lower scores for total and LDL cholesterol. There was also “significant improvement” in beta cell function seen in the zinc group https://onlinelibrary.wiley.com/doi/full/10.1111/1753-0407.12621 Additional Zinc in pancreatic beta cells binds to several insulin molecules, six to be exact, forming what’s called an insulin hexamer for storage - insulin is produced and stored in the body as a hexamer (a unit of six insulin molecules) Chromium In the presence of insulin, the chromodulin molecule changes shape and location in the cell, triggering activation of a vital glucose transporter molecule called GLUT4 Study - The International Journal for Vitamin and Nutrition Research This study investigated the effects of chromium picolinate on elderly diabetic patients within a rehabilitation program. https://www.ncbi.nlm.nih.gov/pubmed/15296075 Lithium A study from the journal Diabetes found that lithium increases in glucose transport activity and causes a modest increase in insulin responsiveness Although the authors concluded, “the effects of lithium on glucose transport and metabolism in skeletal muscle are strikingly similar to the persistent effects of exercise. These results support the possibility that lithium might be useful in the treatment of insulin resistance in patients with non-insulin-dependent diabetes mellitus.” https://diabetes.diabetesjournals.org/content/43/7/903 When skeletal muscle tissues are treated with lithium, the levels of cell surface GLUT4 protein contents are increased https://www.jstage.jst.go.jp/article/jnsv/63/6/63_365/_pdf https://www.ncbi.nlm.nih.gov/pubmed/29332897 https://diabetes.diabetesjournals.org/content/38/5/648

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