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Eli Lilly ($LLY) is quickly catching up in the obesity drug market—and Novo Nordisk ($NVO) might be in trouble.
In this video, I break down three critical challenges Novo is facing in the oral GLP-1 space:
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📌 You'll learn:
– Why Novo is losing momentum in obesity
– What makes Lilly’s strategy so effective
– Whether Novo can turn the tide with its new drugs
👨🔬 About this channel
I have a PhD in Science and 20+ years of experience in global pharma R&D.
Here, I explain the science behind biotech and pharma investing—without the hype.
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This content is for informational purposes only and does not constitute investment advice.
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Calories In Vs. Calories Out = Outdated Science Or Key Fat Loss Principle?
Is “calories in vs. calories out” (CICO) an accurate model for fat loss, or is it "outdated science" like some people try to claim? Do calories matter when it comes to leaning down and burning fat?
This is a pretty common fat loss debate you'll see online nowadays...
One person will state that in order to lose fat, you need to create a calorie deficit by consuming fewer calories than you burn. Someone else will then argue back that calories "don’t matter" because not all calories are the same.
However, the latter statement is fundamentally incorrect right off the bat since a calorie is a constant unit of energy. Just like pounds measure weight or kilometers measure distance, calories measure energy. Therefore a calorie IS a calorie no matter what food it’s contained in.
What people usually mean to say here is that your body will process different *foods* differently depending on their nutrient profile and fiber content, which is true.
For example, 250 calories worth of chicken and broccoli will provide protein for muscle growth and be more micronutrient-dense, higher in fiber, more satiating and have a higher thermic effect than, say, 250 calories of jelly beans.
The calories themselves are the same, but the food they're packaged up in is different. So yes, 2000 calories on paper from one combination of foods will not necessarily produce the same fat burning and muscle building effect as 2000 calories on paper from a different combination.
The problem though is that people will then take this information and make a massive leap by saying that since food quality impacts the way calories are handled from different foods, that this then means that "calories don’t matter" and that calories in vs. calories out is somehow irrelevant.
However, what many fail to realize is that the way food quality impacts fat loss is still primarily a result of how it influences net energy balance, or calories consumed versus calories burned.
For example, eating more protein causes your body to burn more calories through digestion due to it having a higher thermic effect. Eating more fiber causes your body to absorb fewer calories from your protein and fat intake. So, these things are literally affecting the "calories in" and "calories out" portion of the energy balance equation.
The bottom line is that body fat is a stored form of energy, and the way you stimulate your body to release that fat is by creating a calorie deficit where the amount of available energy from the foods you consume is less than what your body requires to fuel itself throughout the day.
To say that calories don’t matter or that calories in vs. calories out is irrelevant is just flat-out incorrect and is a basic misunderstanding of how the fat burning process actually work.
Yes, if your diet is currently very poorly structured (low protein, low fiber, centered around calorie-dense high-fat, high-sugar foods), and you aren’t weight training, fixing those issues by basing your diet around minimally processed whole foods with at least 0.8 grams of protein per pound of body weight daily, more veggies and high-fiber foods along with a good weight training plan - that will help you lose fat in the initial stages probably without needing to track calories at all.
However, once you have a decent fat loss diet with a balanced macronutrient breakdown that is centered around minimally processed whole foods, there isn't much else you can do to manipulate "food quality" beyond that point to continue losing fat.
At that point it really is just about managing calories in versus calories out on paper. (After all, if you're "eating clean" and your fat loss stalls, what do you do then? Eat cleaner?)
This doesn’t necessarily mean you have to track every every single calorie you eat, although most people probably will benefit from tracking at least in the beginning stages.
How many calories should you eat to lose fat in a consistent and sustainable way?
A good sweet spot to aim for is about 300-500 calories below maintenance per day.
To sum up:
Both your calorie intake AND the quality of the foods you eat matter for fat loss, overall health, gym performance and muscle growth.
However, losing body fat ultimately comes down to creating a consistent calorie deficit when it all comes down to it.
That calorie deficit can be partly influenced by your food choices and macronutrient breakdown, but once you have a decent nutrient-rich whole-food diet in place, calories in versus calories out is where your primary focus should be in order to maximize your long-term results.
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When it comes to weight loss, there are many factors to consider, including diet, exercise, and medication. One medication that has been gaining popularity for its weight loss benefits is semaglutide. Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that was originally developed to help manage type 2 diabetes. However, studies have shown that it can also be effective in promoting weight loss in individuals with obesity.
Understanding Semaglutide Dosing
Semaglutide works by mimicking the effects of GLP-1, which helps regulate appetite and food intake. When used for weight loss, semaglutide is typically administered via subcutaneous injection once a week. The recommended dose for weight loss is higher than the dose used for diabetes management, as studies have shown that higher doses of semaglutide are more effective in promoting weight loss.
Patients starting on semaglutide for weight loss are usually prescribed a lower dose, which is gradually increased over time to minimize side effects. It is important for patients to follow their healthcare provider’s instructions carefully and not to adjust their dose without consulting them first.
It is essential to note that semaglutide is not a miracle drug and should be used in combination with a healthy diet and regular exercise for best results. It is also not suitable for everyone, so individuals considering semaglutide for weight loss should discuss their medical history and any existing health conditions with their healthcare provider.
Side Effects and Considerations
Like any medication, semaglutide can cause side effects, including nausea, vomiting, diarrhea, and constipation. These side effects are usually mild and diminish over time as the body adjusts to the medication. However, if side effects persist or become severe, patients should contact their healthcare provider.
Patients taking semaglutide should also be aware of the potential risk of hypoglycemia, especially if they are also taking medications for diabetes. It is essential to monitor blood sugar levels regularly and seek medical attention if experiencing symptoms of low blood sugar, such as dizziness, sweating, or confusion.
Additionally, semaglutide has been associated with rare but serious side effects, such as pancreatitis and thyroid tumors. Patients should be monitored regularly by their healthcare provider to detect any potential complications early on.
Conclusion
In conclusion, the recommended semaglutide dose for weight loss is typically higher than the dose used for diabetes management. Patients starting on semaglutide should follow their healthcare provider’s instructions carefully and be aware of potential side effects and considerations.
Ultimately, the decision to use semaglutide for weight loss should be made in consultation with a healthcare provider, taking into account the individual’s medical history and existing health conditions. With the right guidance and support, semaglutide can be a valuable tool in achieving weight loss goals.
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VIDEO SUMMARY:
How to lose body fat the easy way.
In this video, I share my body transformation where I've gone from 22% body fat to 12% body fat, lost 4 inches off my waist and 2.5 stone.
These results were achieved under these conditions:
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- By doing less than 50 minutes of exercise a week and without stepping foot into a gym.
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I've used a simple mind trick which almost eradicates self-sabotage and procrastination.
Speak soon,
Colin "I've found my abs" Hiles
http://youtu.be/kYYfjJ6IXms
