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Metformin is an oral medication commonly used to manage type 2 diabetes mellitus. It is often the first-line treatment due to its effectiveness, safety profile, and additional benefits beyond blood sugar control.
Mechanism of Action
Metformin primarily works by:
Reducing Hepatic Glucose Production**: It decreases the amount of glucose produced by the liver, particularly by inhibiting gluconeogenesis (the process of generating glucose from non-carbohydrate sources).
Increasing Insulin Sensitivity**: Metformin enhances the sensitivity of peripheral tissues (like muscle and fat) to insulin, facilitating better uptake of glucose from the bloodstream.
Decreasing Intestinal Absorption of Glucose**: It may also reduce the absorption of glucose from the gastrointestinal tract.
Indications
Metformin is indicated for:
Type 2 Diabetes Mellitus**: It is used to improve glycemic control in adults and children (larger than & equal to 10 years), typically in conjunction with diet and exercise.
Polycystic Ovary Syndrome (PCOS)**: Off-label, it is sometimes used to manage symptoms related to insulin resistance in women with PCOS.
Dosage and Administration
Formulations**: Metformin is available in immediate-release and extended-release formulations.
Dosing**: The initial dose is usually low, gradually increased based on tolerance and glycemic control. The maximum dose typically does not exceed 2,000-2,500 mg per day, depending on the formulation.
Side Effects
Common side effects include:
Gastrointestinal issues: Nausea, vomiting, diarrhea, abdominal discomfort, and flatulence (often transient).
Lactic acidosis: A rare but serious side effect, particularly in individuals with renal impairment or contraindicating conditions.
Contraindications
Metformin is contraindicated in:
Severe renal impairment (eGFR less than 30 mL/min)
Acute or chronic metabolic acidosis, including diabetic ketoacidosis
Hypersensitivity to metformin
Cautions
Renal Function Monitoring**: Kidney function should be assessed before starting therapy and regularly monitored during treatment.
Use in Specific Populations**: Caution is advised in patients with liver disease, heart failure, or those undergoing procedures involving contrast media, as these can increase the risk of lactic acidosis.
Benefits Beyond Glycemic Control
Metformin has additional benefits, including:
Weight Management** It is generally weight-neutral or may even promote modest weight loss, making it suitable for overweight individuals with type 2 diabetes.
Cardiovascular Benefits**: Some studies suggest that metformin may have cardiovascular protective effects.
Conclusion
Metformin is a cornerstone in the management of type 2 diabetes, known for its efficacy in lowering blood sugar levels, safety profile, and additional health benefits. As with any medication, it should be prescribed and monitored by a healthcare professional, ensuring that patients receive the most appropriate and effective treatment for their condition. Regular follow-up and lifestyle modifications (diet and exercise) are essential components of diabetes management alongside metformin therapy.
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Trying to lose weight can be a constant struggle.
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So, what is GLP-1?
GLP-1 is a hormone produced naturally in the gut and released after eating. It helps control insulin levels, slows down stomach emptying, and affects areas of your brain that process hunger and fullness, helping you reduce your appetite.
GLP-1 agonist medications are a class of synthetic drugs used to treat Type 2 Diabetes and obesity. Synthetic means not real, fake, artificial… you get the point. Plus, they’re expensive and take a long time before you even see any results.
Millions of US adults have now tried these synthetic meds, and more alarming reports are all over the news about harmful side effects. Some of these have even led to lawsuits resulting from gastroparesis - a paralysis of the stomach muscles.
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Paper: https://doi.org/10.1126%2Fscience.adj2537
Chapters
0:00 – Culinary Kryptonite
1:06 – GLP-1 preingestive satiation
2:46 – DMH is the brain region involved in preingestive satiation
4:14 – Heterogeneity: Rainbows and Froot Loops
5:58 – Anti-Responder?
7:13 – There’s always room for ice cream
10:29 – My prescriptions
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Semaglutide Is A Revolutionary Medication That Supports Weight Loss And Improves
Shark Tank breakout: BioLyfe, creator of an innovative keto supplement, lands their deal with the sharks.Here’s their big announcement: Shark Tank breakout! For those who aren’t familiar with the show, BioLyfe is the first keto supplement company to ever appear on the hit ABC TV show Shark Tank. After pitching their innovative approach to the sharks, they successfully closed the deal and are now on the Shark Tank payroll. Another step closer to revolutionising the keto supplement market!
The Journey to Shark Tank
Before the episode of Shark Tank that put their keto supplements on the map, BioLyfe had already started to make a name for itself in the health and wellness industry. Their keto supplements were different than others on the market because they hadn’t been stripped of all their natural compounds. A dedicated customer base was already growing and enjoying the benefits of the supplements BioLyfe made. When the makers were approached by the producers of Shark Tank to pitch their business to the sharks, they knew they needed to expand.
BioLyfe had descended their podium at Shark Tank prepared to show the sharks their product line and tell them their story, why their products were superior, and how they were helping their customers reimagine what it meant to enjoy a meal. While the sharks were impressed with the quality of BioLyfe’s products and the passion of their team, another game began after their presentation. After a tense negotiation, a deal had been struck that changed the course of BioLyfe’s Shark Tank experience.
In the wake of Shark Tank, consumer interest in BioLyfe’s products has spiked. The visibility of a profile on an international stage helps this fledgling company to reach more customers, become a tastemaker in the keto supplement sphere, and negotiate a partnership with sharks that can help propel its business to the next level.
The Impact of Shark Tank
The exposure from the Shark Tank deal has been integral to BioLyfe’s business success, allowing them to scale up and diversify their offerings. Since Shark Tank, BioLyfe has been able to scale up to a much bigger team, increase production and expand its product line due to the new capital from its shark investors. It’s even branched out into a whole new range of keto supplements, allowing it to reach more customers who are seeking a more sustainable, stripped-back approach to their health.
But coming up with the money for your company isn’t everything; sometimes, the expertise and contacts of the businesspeople behind it are critical. BioLyfe has benefited from the guidance and mentoring of the sharks, which have helped it grow and compete against rivals. Today, with the sharks championing BioLyfe in the market, the future has never looked brighter for the start-up.
To sum up, BioLyfe has been given a golden opportunity on Shark Tank, which helped them secure funds, breakthrough to various investors and improve and expand their business. Their novel products would give them a chance to disrupt the keto supplement industry. It also encourages them to improve their business performance to draw more attention from the market. In conclusion, enjoying massive popularity and dynamic expansion, BioLyfe is a company that is full of vitality. Their special products and passionate team are destined to make a difference in the world of health and wellness.
FAQ
Q: What makes BioLyfe’s keto supplements unique?
Q: So what ingredients and method are used to make BioLyfe’s keto supplements? A: BioLyfe’s whole-food keto supplements are made from the highest-quality ingredients available and are designed to help make keto ventures easier by assisting with fat loss and providing individuals subsistence when embarking on the ketogenic diet. Designed by a leading healthcare professional in the field of keto diet, these products are made from all-natural ingredients that help make ketosis easier and more successful.
Q: How can I purchase BioLyfe’s products?
A: BioLyfe products can be purchased on their website and are also available at select retailers. Keto supplements come in the form of powders, capsules, and snacks to help customers feel happy and healthy.
Q: What sets BioLyfe apart from other keto supplement companies?
A: Excellent products and trust set Biolyfe in a league of its own from other keto supply companies. Dedicated to being cutting edge and dependable, Biolyfe works to ensure their clients have the very best for existing and getting to the next level.
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Breaking Down The Cost Shark Tank Keto Pills Unveiled
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