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Semaglutide is a medication that has been gaining popularity for its potential to help with weight loss. It is a glucagon-like peptide-1 (GLP-1) receptor agonist that works by slowing down digestion, increasing feelings of fullness, and reducing appetite. Originally approved for the treatment of type 2 diabetes, semaglutide has shown promising results in clinical trials for weight management. However, like any medication, semaglutide comes with potential side effects that need to be considered before starting treatment.
Common Side Effects
One of the most common side effects of semaglutide for weight loss is gastrointestinal issues. These can include nausea, vomiting, diarrhea, and constipation. These side effects are usually mild to moderate in severity and tend to improve over time as the body adjusts to the medication. It is important to follow dosing instructions carefully and talk to your healthcare provider if you experience persistent or severe gastrointestinal symptoms.
Another common side effect of semaglutide is decreased appetite. While this can be a desirable effect for those trying to lose weight, it can also lead to unintended weight loss or nutritional deficiencies if not managed properly. It is important to work closely with your healthcare provider to monitor your weight and nutritional status while taking semaglutide.
Some people may experience injection site reactions with semaglutide, such as redness, swelling, or itching at the injection site. These reactions are usually mild and resolve on their own. If you experience persistent or severe injection site reactions, talk to your healthcare provider about possible solutions or adjustments to your treatment plan.
Less Common Side Effects
Less common but more serious side effects of semaglutide can include pancreatitis, gallbladder problems, thyroid tumors, and kidney problems. These side effects are rare but can be potentially life-threatening if not addressed promptly. It is important to be aware of the signs and symptoms of these side effects and seek medical attention immediately if you experience any concerning symptoms.
Some people may also experience allergic reactions to semaglutide, such as rash, itching, or difficulty breathing. If you have a history of allergies or experience any allergic symptoms while taking semaglutide, seek medical attention right away. It is important to disclose any known allergies to your healthcare provider before starting treatment with semaglutide.
Other less common side effects of semaglutide can include headaches, dizziness, fatigue, and changes in taste. These side effects are usually mild and transient, but if they persist or worsen, discuss them with your healthcare provider. It is important to report any new or worsening symptoms while taking semaglutide to ensure safe and effective treatment.
FAQ
Q: Can semaglutide be used for weight loss in people without diabetes?
A: Yes, semaglutide has been studied for weight management in people without diabetes and has shown promising results. However, it is important to discuss the risks and benefits with your healthcare provider before starting treatment.
Q: How long does it take to see results with semaglutide for weight loss?
A: Results can vary, but many people start to see weight loss within the first few weeks of starting semaglutide. It is important to follow a healthy diet and exercise plan while taking semaglutide to maximize the benefits of treatment.
Q: Are there any dietary restrictions while taking semaglutide?
A: There are no specific dietary restrictions while taking semaglutide for weight loss, but it is important to follow a balanced and healthy eating plan to support your weight loss goals. Your healthcare provider can provide guidance on nutrition and meal planning while taking semaglutide.
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Dr. Lee-Ching Chang, MD, an endocrinologist at Brigham and Women’s Hospital, reviews key trials highlighting the benefits of SGLT2i and GLP-1 RAs and the compelling reasons for choosing one over the other. Medical indications, comorbidities and side effects, and administration differences are discussed.
00:00 | Introduction
01:00 | Cardiovascular outcomes trials
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06:21 | Choosing SGLT1 inhibitors vs GLP-1 receptor agonists
This video was peer reviewed by Dr. Jonathan Salik, TMD, MHPEd, Instructor of Medicine, Massachusetts General Hospital; and Dr. Sugantha Sundar, MD, Assistant Professor of Anesthesia, Beth Israel Deaconess Medical Center, to validate the quality and accuracy of the content.
References:
Das SR, et al. 2020 Expert Consensus Decision Pathway on Novel Therapies for Cardiovascular Risk Reduction in Patients with Type 2 Diabetes. J Am Coll Cardio. 2020: 76(9): 1117-45. Published 2020 Sep 1. Accessed 22 Jan 2022.
Notice: At this time, the content in this video is not accredited.
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