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Semaglutide is effective for both weight loss and type 2 diabetes. Compared to other weight-loss medications, semaglutide has shown superior results. Meta-analyses reveal that semaglutide can reduce body weight by 15-20% in obese individuals over 68 weeks. The medication also improves cholesterol levels and blood pressure. Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist. It stimulates the pancreas to increase insulin production, lowering high blood sugar. The drug inhibits the production of glucagon and gluconeogenesis in the liver. Semaglutide enhances insulin sensitivity and effectively manages diabetes. It helps control appetite by slowing stomach emptying and signaling the brain to feel full. Despite its effectiveness, semaglutide is usually not the first-line treatment for diabetes, which is typically metformin. The drug is administered via injections and has a long action span of seven days. An oral form of semaglutide is under Phase 3 clinical trials and could be available in 2024. Animal studies suggest a potential risk of thyroid cancer, although this has not been confirmed in humans.
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