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Zepbound, tirzepatide, was approved on Nov 8 by the FDA. Expect it to be available in the coming months. This is yet another injectable weight-loss drug to hit the market and is the same formula as the already approved Wegovy that is indicated for type 2 diabetes. It activates both GIP, glucose-dependent isulinotropic polypeptide, and GLP-1, glucagon-like peptide-1, hormone receptors. Criteria for use are a BMI greater than 30 or a BMI between 25-30 with another chronic condition like obstructive sleep apnea, high blood pressure, high cholesterol, and diabetes. At the highest dose, Zepbound lead to 25% loss of body weight in the SURMOUNT-1 and SURMOUNT-2 trials. Nausea, vomiting, and abdominal pain are common adverse effects. Although rare, sometimes side effects can be severe and it may lead to severe stomach problems, kidney problems, gallbladder problems, pancreatitis, allergic reactions, low blood sugar, changes in vision or depression and thoughts of suicide. This and other GLP-1 and GIP activators should not be used if you have a history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2. As always, everyone’s situation is unique, so please discuss the risks and benefits with your provider. I hope this is helpful!
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#ketodiet #ketodieting #ketorecipes #ketogenic : Secrets of Successful Weight Loss and Shortcomings The #ketogenic (keto) diet is a high-fat, moderate-protein, and low-carbohydrate diet that shifts the body into a metabolic state called ketosis. In this state, the body burns fat as its primary energy source, leading to rapid weight loss and improved metabolic health for some individuals. Pros of the Keto Diet: 1. Promotes quick weight loss by utilizing fat as fuel. 2. Reduces appetite, leading to fewer calories consumed. 3. May improve insulin sensitivity, blood sugar control, and metabolic markers. 4. Shows promise for neurological conditions, such as epilepsy. Cons of the Keto Diet: 1. Common initial side effects include the “keto flu” (fatigue, nausea, and headaches). 2. Long-term sustainability is challenging due to restrictive food choices. 3. Nutrient deficiencies, increased cholesterol, and risks to kidney/liver health can arise. 4. Social and lifestyle factors make adherence difficult for some individuals. The keto diet can be an effective tool for weight loss and certain health conditions, but it requires proper planning, monitoring, and consultation with healthcare providers. A balanced approach is key to maximizing benefits while minimizing risks. #healthcityvistaar #drkpchandra #drrajivawasthi #nitinranjangupta
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