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Obesity isn’t just about willpower—it’s a chronic disease shaped by biology, genetics, and environment. In this podcast, we’ll explore why GLP-1 medications are a game-changing, long-term solution for successful weight loss. From set point theory and genetic predisposition to hormonal dysregulation, insulin resistance, brain chemistry, and gut hormones, we’ll break down the science behind weight gain and loss. Learn how GLP-1 medications target these complex systems, addressing stress eating, reward pathways, and environmental factors. Discover why maintaining weight loss can be challenging without these tools and how they redefine the path to sustainable health.
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This Harvard Medical School Continuing Education video examines the key question: Do you know when to use an SGLT2 inhibitor versus a GLP-1 receptor agonist with your patients? Dr. Lee-Shing Chang, MD, an endocrinologist at Brigham and Women’s Hospital in Boston, Massachusetts, reviews compelling reasons to choose an SGLT2 inhibitor (SGLT2i) vs a GLP-1 receptor agonist (GLP-1 RA). Medical indications, comorbidities and side effects, and the administration of SGLT2i and GLP-1 RA are discussed and compared. 00:00 | Introduction 00:57 | Medical indications for SGLT2i and GLP-1 RA 03:00 | Comorbidities and side effects of SGLT2i and GLP-1 RA 6:07 | Administration differences between SGLT2i and GLP-1 RA This video was peer reviewed by Dr. Jonathan Salik, TMD, MHPEd, Instructor of Medicine, Massachusetts General Hospital; and Dr. Sugantha Sundar, MD, Assistant Professor of Anesthesia, Beth Israel Deaconess Medical Center, to validate the quality and accuracy of the content. References: Das SR, et al. 2020 Expert Consensus Decision Pathway on Novel Therapies for Cardiovascular Risk Reduction in Patients with Type 2 Diabetes. J Am Coll Cardiol. 2020: 76(9): 1117-45. Published 2020 Sep 1. Accessed 22 Jan 2022. Notice: At this time, the content in this video is not accredited.
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