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Learn about the design of a trail-blazing Randomized Controlled Trial (RCT) that will explore the physiology and biology of brain energy metabolism, while also informing clinical applications of ketogenic therapy as an adjunctive treatment option for patients with bipolar and schizophrenia spectrum disorders. RCTs are considered the gold standard when looking at the efficacy and safety of new treatment options. This type of research is necessary to understand whether ketogenic therapy should be offered as a first-line treatment option, as well as what types of strategies could increase accessibility of this intervention in the future. Dr. Bret Scher interviews principal investigators Dost Öngür, MD, PhD, and Dr. Virginie-Anne Chouinard, MD, about the details of this trial at McLean Hospital, a top-rated, Harvard-affiliated psychiatric hospital. Learn more about the impressive design of this trial which includes a multidisciplinary approach to clinical care, gathering a variety of data to inform understanding of underlying brain energy mechanisms (including MRIs and metabolic markers), and an “open-label” approach that will allow the control group to opt into ketogenic therapy at the end of the first trial phase if desired. Dr. Dost Öngür William P. and Henry B. Test Professor of Psychiatry, Chief of the Division of Psychotic Disorders, & Director of the Schizophrenia and Bipolar Disorder Research Program at McLean Hospital https://www.mcleanhospital.org/profile/dost-ongur Dr. Virginie-Anne Chouinard, Staff psychiatrist and Director of Research at McLean OnTrack™ & Instructor in Psychiatry at Harvard Medical School. https://www.mcleanhospital.org/profile/virginie-anne-chouinard Press release about the trial: https://www.prnewswire.com/news-releases/mclean-hospital-launches-clinical-trial-of-ketogenic-therapy-for-bipolar-disorder-302062402.html For information on enrolling: https://clinicaltrials.gov/study/NCT06221852 Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry. Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/ About us: Metabolic Mind is a non-profit initiative of Baszucki Group working to transform the study and treatment of mental disorders by exploring the connection between metabolism and brain health. We leverage the science of metabolic psychiatry and personal stories to offer education, community, and hope to people struggling with mental health challenges and those who care for them. Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. Consult your healthcare provider before changing your lifestyle or medications. Timestamps 0:00 Introduction 2:03 Interest leading up to a keto for bipolar study 5:36 Brain energy metabolism and bipolar 7:44 Patient population for the new Harvard study 8:46 About the study 9:21 Dietary studies vs pharmacologic studies 11:55 The different interventions in the keto for bipolar study 14:42 What researchers will be looking at during the clinical trial 17:20 Balancing mechanism and clinical impact in research 19:21 Impact of the clinical trial 21:54 Working with a clinician for ketogenic therapy 25:30 Conclusion #MetabolicMind #KetoForMentalHealth #MetabolicPsychiatry #BipolarDisorder #MetabolicNeuroscience #KetogenicMetabolicTherapy #NutritionalKetosis #MentalIllness #AlternativeTreatment #Obesity #MedicationSideEffects #Schizophrenia #SchizoaffectiveDisorder #SchizophreniaSpectrumDisorders
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They said Ozempic could melt fat away without the struggle... but is that the real story? 😳 In this video, a doctor breaks down the TRUTH behind Ozempic and its shocking effects on weight loss. 💉 ✨ How does it actually work? 🚨 The hidden risks no one talks about! 💸 Is it REALLY worth the insane cost? Before you consider using Ozempic for weight loss, WATCH THIS. You’ll be stunned by what you discover! ➡️ Hit Subscribe for more no-hype, real medical breakdowns every week! ➡️ Like and Share if you think the truth needs to be heard! #Ozempic #WeightLoss #HealthTruths #WeightLossJourney #DoctorExplains
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It's no secret that America is facing an obesity crisis. But is there hope on the horizon? The new wave of weight-loss medications — Wegovy and Zepbound — certainly seem to be game changers. Whereas previous options helped people lose only around 5% of their weight, these new medications can lead to up to 22% weight loss. But you're not alone if you have questions. In this episode, we discuss everything we know (and don't yet know) about the new class of weight-loss medications. Expert: Dr. Garth Davis, Weight Loss Surgeon Interviewer: Zach Moore Notable topics covered: - The many reasons why losing weight often isn't as simple as diet and exercise - How the new wave of weight-loss medications work - All about GLP-1 agonists, including why achieving "the GLP-1 effect" promotes weight loss - Who should consider taking these medications? And are they covered by insurance? - Just one tool to get weight off: why diet and exercise still matter - Will you need to stay on this medication forever? - How these medications also benefit heart health, type 2 diabetes management and more - The potential side effects of weight-loss medications - Weight-loss medications vs. supplements - How weight-loss medication compares to bariatric surgery
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