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These drugs--Tirzepatide and Semaglutide--are not just changing the weight loss game. Every day new information is published regarding their efficacy in a wide range of chronic illnesses. They give us an exciting new tool for the management of complex illness.
- The topic is GLP-1 receptor agonists (GLP-1 RAs), such as Ozempic, Wegovy, and Mounjaro (semaglutide and tirzepatide).
- These drugs, originally developed for diabetes and weight loss, are being explored for broader benefits in patients with complex chronic illnesses, including long COVID and mast cell activation syndrome (MCAS).
### **Clinical Observations**
- The hosts recount remarkable improvements in patients with severe, treatment-resistant symptoms (e.g., long COVID, MCAS) after starting very low doses of GLP-1 RAs.
- Examples include:
- A physician with disabling long COVID who, after starting a low dose of tirzepatide, regained mobility and improved overall function.
- A woman with post-COVID and post-vaccine reaction, severe edema, food intolerance, and autoimmune markers, who experienced a dramatic reduction in swelling and improved food tolerance after just three injections.
### **Mechanisms & Theoretical Discussion**
- GLP-1 is a natural hormone involved in insulin secretion and glucose metabolism; synthetic versions are longer-acting.
- GLP-1 receptors are found throughout the body: central nervous system, muscles, immune cells (including mast cells), joints, and more.
- The hosts hypothesize that the drugs’ benefits in complex illness may stem from:
- Mast cell stabilization (reducing multi-system inflammation).
- Modulation of immune function.
- Effects on the central nervous system, possibly crossing the blood-brain barrier.
- Notably, benefits are observed at microdoses (one-tenth or less of standard diabetes/weight loss doses), with minimal side effects.
### **Clinical Pearls & Practical Considerations**
- Patients who are not overweight also benefit, and weight loss is minimal at these low doses.
- Appetite suppression and improved food tolerance are common, leading to better quality of life.
- The hosts encourage patients to re-challenge foods they previously could not tolerate after starting treatment.
- There is curiosity about whether increasing the dose would yield further benefits or more side effects.
- The drugs also seem to help with neurological symptoms, joint pain, and possibly even visual disturbances associated with long COVID.
### **Barriers and Logistics**
- Insurance typically does not cover these drugs for off-label use, so patients rely on compounding pharmacies.
- Recent FDA actions threaten the availability of compounded versions, as compounding is only allowed during official shortages.
- Dosing compounded versions can be confusing, as patients must measure their own doses with insulin syringes, unlike the user-friendly commercial pens.
### **Mechanistic and Evolutionary Speculation**
- The hosts discuss why GLP-1 receptors are so widespread, theorizing that modern diets and processed foods have disrupted normal physiology, and these drugs may help restore balance.
- They propose that GLP-1 RAs could become important in anti-aging/longevity medicine due to their anti-inflammatory effects, similar to drugs like metformin and rapamycin.
### **Research & Future Directions**
- The hosts call for more systematic data collection, including biomarkers of inflammation, to better understand and track the drugs’ effects.
- They note the lack of robust clinical trial data for these off-label uses and suggest the need for case series and further research.
- There is interest in comparing different GLP-1 RAs (semaglutide vs. tirzepatide) and their relative efficacy for inflammation vs. weight loss.
### **Conclusion**
- The hosts are enthusiastic about the potential of GLP-1 RAs in treating complex chronic illnesses, especially given the rapid and profound improvements seen in some patients.
- They plan to revisit the topic as more experience and data accumulate, and to explore combination therapy with other anti-inflammatory/anti-aging drugs like rapamycin.
## **Key Takeaways**
- **GLP-1 receptor agonists, at very low doses, appear to provide significant, rapid benefits for some patients with chronic, complex illnesses (e.g., long COVID, MCAS), beyond their approved uses.**
- **Benefits include reduced inflammation, improved mobility, better food tolerance, and improved neurological symptoms.**
- **Mechanisms may involve mast cell stabilization, immune modulation, and central nervous system effects.**
- **Access is limited by insurance and regulatory issues; compounded versions are threatened by FDA policy changes.**
- **There is a need for more systematic research, including biomarker tracking and case series, to validate these observations.**
- **GLP-1 RAs may have a future role in longevity and anti-aging medicine due to their anti-inflammatory properties.**
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Muskelschwund bei Mounjaro, Wegovy oder Ozempic was tun?
Aktuelle Methoden zur Gewichtsreduktion wie beispielsweise Diäten, Magen-Ops und auch beliebte Therapien mit Ozempic, Wegovy oder Mounjaro können zu Fett- aber auch Muskelverlust führen, welches die Kraft verringern und das Sturzrisiko erhöhen kann. Das ist vor allem ein Problem bei älteren Patienten. In der STEP 1-Studie, nachzulesen auch bei Pubmed, verloren Patienten mit Adipositas eine Muskelmasse von etwa 40 % des reduzierten Körpergewichts. Der genaue Betrag an Muskelmasse, der verloren geht, kann jedoch von Person zu Person unterschiedlich sein und hängt von verschiedenen Faktoren ab, wie z.B. der Ernährung, dem Trainingsprogramm usw. Daher: wie ist das bei euch so? Wieviel Gewicht habt ihr bisher abgenommen und wieviel davon waren Muskelmasse?
Unternehmen entwickeln seid geraumer Zeit auch Kombi-Behandlungen zur Gewichtsreduktion, die dabei helfen sollen, mehr Muskeln zu erhalten. Der Fokus ist jetzt also nicht mehr allein die höchste prozentuale Gewichtsabnahme sondern die Qualität der Abnahme. Dazu später noch mehr.
Wie kann man jetzt den MUSKELABBAU unter der Mounjaro, Wegovy bzw Ozempic Therapie minimieren?
Nr.1 Stress vermeiden!
Nr.2 Ausdauer und vor allem Krafttraining: mehr Gewichte weniger Wiederholungen
Nr.3 GENÜGEND ENERGIE TANKEN: Ausreichender Schlaf. Nutze Trainingspausen, um dich zu regenerieren.
Nr.4: mehr Proteinereiche Nahrung zu euch nehmen. Evtl. auch Eiweißshakes
Nr.5 Auf Alkohol weitestgehend verzichten: Alkohol entzieht dem Körper Wasser, wodurch die Muskulatur weniger mit Nährstoffen versorgt wird
Nr. 6 mit dem Rauchen aufhören.
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Lose Fat Gain Results Proven Tips For Your Fitness Journey Weightloss
Semaglutide, a medication primarily used to treat type 2 diabetes, has gained popularity in recent years for its weight-loss benefits. Studies have shown that when taken at the right time of day, semaglutide can be even more effective in promoting weight loss. Understanding the optimal times to take semaglutide can help maximize its weight-loss benefits and improve overall health outcomes.
Morning Dose
Many healthcare professionals recommend taking semaglutide in the morning to help control appetite throughout the day. By taking the medication in the morning, individuals may experience reduced hunger and cravings, which can lead to consuming fewer calories and ultimately, weight loss. Additionally, taking semaglutide in the morning can help regulate blood sugar levels and improve insulin sensitivity, which are essential for weight management.
Some studies have suggested that taking semaglutide in the morning may also lead to better sleep quality, which is important for overall health and well-being. By optimizing sleep patterns, individuals may experience improved energy levels, mood, and cognitive function, all of which can contribute to better weight-loss outcomes.
Overall, taking semaglutide in the morning can set a positive tone for the day, helping individuals make healthier food choices, feel more satiated, and stay on track with their weight-loss goals. However, it is important to consult with a healthcare provider before adjusting the timing of semaglutide dosing to ensure safety and effectiveness.
Afternoon Dose
Alternatively, some individuals may find it more convenient to take semaglutide in the afternoon. By taking the medication in the afternoon, individuals can benefit from its appetite-suppressing effects during key periods of the day, such as during snack cravings or meal preparation. This can help individuals make healthier food choices and reduce overall calorie intake, leading to weight loss over time.
Additionally, taking semaglutide in the afternoon may help individuals avoid overeating during dinner or late-night snacking, which are common pitfalls for those trying to lose weight. By curbing appetite in the afternoon and evening, individuals can better control their portion sizes and reduce the likelihood of weight gain.
Some studies have shown that taking semaglutide in the afternoon may also improve insulin sensitivity and blood sugar control, which are important factors in weight management. By optimizing these metabolic processes, individuals may experience enhanced weight-loss results and improved overall health outcomes.
Evening Dose
For some individuals, taking semaglutide in the evening may be the most suitable option. By taking the medication in the evening, individuals can benefit from its appetite-suppressing effects during crucial evening hours, when cravings are often at their peak. This can help individuals avoid late-night snacking and make healthier food choices, ultimately supporting weight-loss efforts.
Additionally, taking semaglutide in the evening may help individuals relax and unwind after a long day, promoting better sleep quality. Adequate sleep is essential for weight loss and overall health, as it regulates hunger hormones, boosts metabolism, and supports healthy brain function. By optimizing sleep patterns, individuals can enhance their weight-loss results and improve their overall well-being.
While taking semaglutide in the evening can be beneficial for some individuals, it is important to consider individual preferences and lifestyle factors when determining the optimal dosing time. Consulting with a healthcare provider can help individuals tailor their semaglutide dosing schedule to suit their needs and maximize weight-loss effectiveness.
Before Meals
Regardless of the time of day, taking semaglutide before meals can enhance its weight-loss benefits. By taking the medication before meals, individuals can benefit from its appetite-suppressing effects and improved insulin sensitivity, which can help regulate blood sugar levels and promote weight loss. Additionally, taking semaglutide before meals may help individuals feel more satisfied after eating, leading to reduced calorie intake and better portion control.
Studies have shown that taking semaglutide before meals can also improve digestive health and nutrient absorption, which are essential for overall well-being. By optimizing digestion and nutrient uptake, individuals can support their weight-loss goals and improve their overall health outcomes. However, it is important to follow healthcare provider recommendations and dosing instructions when taking semaglutide before meals to ensure safety and effectiveness.
Overall, taking semaglutide before meals, regardless of the time of day, can help individuals maximize its weight-loss benefits and improve their overall health outcomes. By incorporating semaglutide into a healthy lifestyle routine, individuals can enhance their weight-loss results and achieve long-lasting success in managing their weight and improving their well-being.
FAQ and Summary
In conclusion, understanding the optimal times of day to take semaglutide for maximum weight-loss effectiveness can help individuals achieve their desired outcomes and improve their overall health. Whether taken in the morning, afternoon, or evening, or before meals, semaglutide can be a powerful tool in supporting weight-loss efforts when dosed correctly. Consulting with a healthcare provider is essential in determining the best dosing schedule for each individual’s needs and goals. By incorporating semaglutide into a comprehensive weight-loss plan that includes a healthy diet, regular exercise, and adequate sleep, individuals can optimize their weight-loss results and improve their overall well-being. Take control of your weight loss journey today with semaglutide and maximize its benefits for a healthier, happier you.
Updates On Semaglutide For Weight Loss From Endo 2021
Dr. Christle Guevarra!!!! Residing here in Michigan, who may have seen being featured in doctor's Mike Israetel page many many times.... she is read to talk to us about herself and her current journey dealing with huge appetite & semiglutide. (GLP-1 Med)
She holds a Master of Science in Chemistry from the University of Wisconsin-Madison and a Doctor of Osteopathic Medicine from Western University of Health Sciences.
Passionate about education, she was awarded a Pre-Doctoral Teaching Fellowship at WesternU, where she taught osteopathic medical students.
Currently, she maintains a telemedicine private medical practice, serves as a traveling team physician for US Figure Skating, and is a project manager for Renaissance Periodization.
My favorite part about our conversation and her, Dr Christle is a BIG believer of Exercise Is Medicine!!
QUALITY muscle and a woman on our side, helping us realize that EVERYONE deserves to feel well, have the life we want and that we are ALL worthy of the body we want.
She believes in “practicing what you preach.” A former competitive powerlifter, she now enjoys typical lifting while also training for Brazilian Jiu Jitsu. Being transparent is a gift she gives us making so much of her own struggling worth it to help the people around her, clients, friends , patients and us!!
HERE is a special FALL food recipes from me to help with ideas of healthy foods!!
https://www.fasterwaytofatloss.com/guide/fast-fall-meal-guide?aid=Pamgreshock
To join my email list, or my 6 week online coaching go here:
https://www.fasterwaycoach.com/?aid=Pamgreshock
To learn more about Christle and follow her, you can find her on Instagram.
Her Youtube is here: for Renaissance Periodization,
Your biggest CHEERLEADER,
xo
Pam
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2. Is it safe to eat Keto ACV Weight Loss Gummies? Keto ACV Weight Loss Gummies are generally safe to eat for most people but if you have a pre-existing condition or are taking any medication, please make sure to consult with your healthcare professional before taking any dietary supplements.
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