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Dr. Chris Palmer, author of 'Brain Energy,' joins One Mind’s Director of Clinical Programs, Dr. Irene Hurford, to discuss Metabolic Psychiatry, how it works, and who can benefit from it. For more on Dr. Palmer's book "Brain Energy: A Revolutionary Breakthrough in Understanding Mental Health--and Improving Treatment for Anxiety, Depression, OCD, PTSD, and More" see here: https://brainenergy.com In this episode of "One Scientist's Mind," Dr. Christopher Palmer, a psychiatrist and assistant professor at Harvard McLean, shares his revolutionary theory of Brain Energy. Dr. Palmer's theory proposes that all mental disorders are metabolic disorders of the brain; he explains how factors like the ketogenic diet, alcohol, marijuana, and sleep can impact mitochondrial function and ultimately our mental health. Watch this video to hear Christopher's eureka moments, his thoughts on antipsychotics, and his ideas for clinical trials. Key Moments: 00:00 - How Dr. Palmer's Career Was Inspired By His Mother 04:51 - Dr. Palmer's Theory of Brain Energy 08:20 - The Role of Mitochondria in Neurotransmitters, Hormones, & Inflammation 10:30 - The Keto Diet, Weight Loss, & Reducing Psychiatric Symptoms 11:56 - How Antipsychotic Medications Can Cause Metabolic Harm 12:49 - How Metabolic Dysfunction Can Result in Underactivity or Overactivity 16:32 - Benefits of the Ketogenic Diet for People with Treatment-Resistant Illness 16:51 - Why Dr. Palmer's Treatment Plan is Holistic & Includes Dietary Interventions 17:56 - Dr. Palmer on Conducting 5 Controlled Trials of Ketogenic Diet for SMI 18:44 - Dr. Palmer: Metabolic Treatment Approach Could Help More than 50% of Patients ABOUT ONE MIND One Mind is the leading brain health nonprofit committed to healing the lives of people impacted by brain illness and injury through global, collaborative action. One Mind catalyzes visionary change through science, business, and media to dismantle stigma and discrimination and transform the world’s mental health. One Mind accelerates collaborative research and advocacy to enable all individuals facing brain health challenges to build healthy, productive lives. FOLLOW ONE MIND Facebook: https://www.facebook.com/onemindorg Instagram: https://www.instagram.com/OneMindOrg Twitter: https://twitter.com/OneMindOrg TikTok: https://www.tiktok.com/@onemindorg Website: https://onemind.org #Keto #KetoDiet #Metabolism #Ketogenic #KetogenicDiet #AskTheExpert #Psychiatrist #Psychiatry #MetabolicDisorders
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Alzheimer's disease is a type of dementia characterized by memory loss, cognitive decline, and a decline in the ability to perform daily tasks (e.g., planning and organizing). It can also affect mood and personality and impair judgment and language. Research has shown that Alzheimer’s results from amyloid plaques and neurofibrillary tangles in brain tissue, which affect communication between brain neurons. The quest for effective treatments remains a high priority. Among the promising therapeutic avenues being investigated, GLP-1 (glucagon-like peptide-1) agonists, traditionally used for managing type 2 diabetes and weight, have garnered significant attention for their potential benefits in Alzheimer's disease. In this podcast, we’ll discuss the potential use of GLP-1 agonists in Alzheimer’s disease and how they work. Understanding GLP-1 Agonists GLP-1 agonists are a class of medications primarily used to enhance insulin secretion and improve glycemic control in patients with type 2 diabetes and obesity. They mimic the effects of the natural hormone GLP-1, which is involved in glucose metabolism and appetite regulation. Besides their glucose-lowering properties, GLP-1 agonists have been observed to have various effects beyond glucose control, including neuroprotective properties. Mechanisms of Action of GLP-1 Agonists in Alzheimer's Disease Neuroprotection: GLP-1 agonists have been shown to exert neuroprotective effects in preclinical models of Alzheimer's disease. They may help protect neurons from damage and death, which is crucial in a disease characterized by widespread neuronal loss. The mechanisms through which GLP-1 agonists provide neuroprotection include reducing oxidative stress, inflammation, and apoptosis (cell death). Amyloid Beta and Tau Pathology: Alzheimer's disease is marked by the accumulation of amyloid beta plaques and tau tangles in the brain. Some studies suggest that GLP-1 agonists might influence the pathology associated with Alzheimer's disease by reducing amyloid beta deposition and tau phosphorylation. While these effects have been observed in animal models, translating these findings to human patients requires further research. Cognitive Function: Clinical trials and studies have explored the impact of GLP-1 agonists on cognitive function in Alzheimer's patients. Preliminary results are promising, with some research indicating that GLP-1 agonists may improve cognitive function and slow cognitive decline. This effect is thought to be linked to the drugs’ ability to enhance neurogenesis (the formation of new neurons) and synaptic plasticity (the ability of synapses to strengthen or weaken over time). Metabolic Regulation: Alzheimer’s disease has been associated with metabolic dysfunctions, including insulin resistance and impaired glucose metabolism. GLP-1 agonists, by improving insulin sensitivity and glucose regulation. This might address some of these metabolic abnormalities, potentially offering an additional benefit in managing Alzheimer’s disease. Clinical Evidence and Future Directions Research into the use of GLP-1 agonists for Alzheimer’s disease is still in its infancy, and larger, well-designed clinical trials are needed to confirm their efficacy and safety in this new context. Moreover, while GLP-1 agonists show promise, they are not without side effects, including stomach-related side effects such as nausea, diarrhea, and constipation. As such, their use in Alzheimer’s disease will require careful consideration of the risk-benefit profile for individual patients. Thanks again for listening to The Peptide Podcast. We love having you as part of our community. If you love this podcast, please share it with your friends and family on social media, and have a happy, healthy week! We're huge advocates of elevating your health game with nutrition, supplements, and vitamins. Whether it's a daily boost or targeted support, we trust and use Momentous products to supercharge our wellness journey. Momentous only uses the highest-quality ingredients, and every single product is rigorously tested by independent third parties to ensure their products deliver on their promise to bring you the best supplements on the market.
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