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[ NEWS] - Why Fans Think Angela Deem's Weight Loss Changed Her Personality
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“Real meals. Real results. This is what a day of eating looks like on 0.75 Trulicity (GLP-1). I’m not gatekeeping my journey—here’s what’s actually working.”
(Optional addition for personality:) “Still figuring it out, but I’m proud of this progress.”
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CardioNerds (Drs. Gurleen Kaur and Richard Ferraro) and episode FIT Lead Dr. Spencer Carter (Cardiology Fellow at UT Southwestern) discuss the clinical implementation of GLP-1 receptor agonists with Dr. Neha Pagidapati (Faculty at Duke University School of Medicine). In this episode of the CardioNerds Cardiovascular Prevention Series, we discuss the clinical implementation of glucagon-like peptide-1 (GLP-1) receptor agonists. We cover the clinical indications, metabolic and cardiovascular benefits, and potential limitations of these emerging and exciting therapies. Show notes were drafted by Dr. Spencer Carter. Audio editing was performed by CardioNerds Academy Intern, student Dr. Pacey Wetstein.
This episode was produced in collaboration with the American Society of Preventive Cardiology (ASPC) with independent medical education grant support from Novo Nordisk. See below for continuing medical education credit.
Claim CME for this episode HERE.
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Pearls and Quotes - Clinical Implementation of GLP-1 Receptor Agonists
GLP-1 agonists work through a variety of mechanisms to counteract metabolic disease. They increase insulin secretion, inhibit glucagon secretion, slow gastric motility, and increase satiety to limit excess energy intake.
Patients with type II diabetes and an elevated risk for atherosclerotic cardiovascular disease should be considered for GLP-1 agonist therapy regardless of hemoglobin A1c.
GLP-1 agonists offer significant ASCVD risk reduction even in the absence of diabetes. Newer data suggest a significant reduction in cardiovascular events with GLP-1 agonist therapy in patients who are overweight or obese and have a prior history of heart disease.
GLP-1 agonists should generally be avoided in patients with a history of medullary thyroid cancer or MEN2. As these medications slow gastric emptying, relative contraindications include history of recurrent pancreatitis and gastroparesis.
GLP-1 agonists should be initially prescribed at the lowest dose and slowly uptitrated to avoid gastrointestinal side effects.
Show notes - Clinical Implementation of GLP-1 Receptor Agonists
What were the groundbreaking findings of the STEP1 and SURMOUNT-1 trials and how these impact cardiovascular wellness?
The STEP1 and SURMOUNT trials demonstrated sustained clinically relevant reduction in body weight with semaglutide and tripeptide, respectively, in patients with overweight and obesity. As obesity is an important risk factor for the development of cardiovascular disease, weight reduction meaningfully contributes to cardiovascular wellness.
What were the findings of the LEADER trial and their implications for patients with type II diabetes and high cardiovascular risk?
The LEADER trial demonstrated a significant reduction in the rate of cardiovascular death, nonfatal MI, or nonfatal stroke in patients with type II diabetes treated with liraglutide. GLP-1 receptor agonist therapy should be considered in all patients with type II diabetes and elevated ASCVD risk regardless of A1c or current hyperglycemic therapy.
What are current indications for GLP1 agonists in the context of cardiometabolic disease.
GLP-1 receptor agonists should be considered in patients with type II diabetes and high ASCVD risk OR patients without diabetes who are overweight/obese and have a history of cardiovascular disease.
What are important side effects or contraindications to GLP1 agents when used for cardiovascular risk reduction and wellness?
GLP-1 receptor agonists should be avoided in patients with a history of medullary thyroid cancer or MEN2. Relative contraindications include recurrent pancreatitis, gastroparesis,
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Supplements are usually the go-to for most people when it comes to achieving and maintaining ketosis. In recent years, this has made BHB Keto Gummies one of the most popular supplements. These gummies contain beta-hydroxybutyrate (BHB) which is a ketone that plays a vital role in energy production of the body during ketosis. In this article, we will focus on the relationship between BHB and keto supplements by explaining about BHB Keto Gummies.
Beta-Hydroxybutyrate: The Science Behind It
During fasting or low carbohydrate intake periods, BHB also referred to as beta-hydroxybutyrate is one of three main ketone bodies produced by the liver. Instead of carbohydrates, fat becomes the body’s fuel during such a state called ketosis. This results in production of ketones like BHB that can be used by muscles and brain for energy.
Ketones like BHB can cross the blood-brain barrier and provide more stable long-lasting energy for the brain contrary to glucose which is its primary source in non-ketogenic states. For this reason, ketogenic diets and other supplements promoting ketosis such as BHB Keto Gummies are frequently found helpful in supporting mental clarity, focus and cognitive functions.
Moreover, since it supplies energy to the brains, beta-hydroxybutyrate is involved in metabolism regulation and weight loss promotion too. According to researches done so far it has been found out that increased metabolic rate hunger suppression as well as enhanced fat burning capacity could be achieved through consumption of BHB thus making it one of favorites among those who want to lose weight while on ketogenic diet.
The Role Played By Beta-Hydroxybutyrate (Bhb) In Keto Supplements Like Bhb Keto Gummies
One key reason why keto products including BHB Keto Gummies have embraced BHb as their ingredient is because it elevates blood ketone levels faster thereby inducing ketosis. By taking exogenous ketones such as BHB, it is possible to boost the body’s natural formation of ketones and hence enter into ketosis considerably quicker.
BHB Keto Gummies also serve as a simple and yummy way through which you can increase your level of ketones without having to go strict on your diet or fasting. Because of this, they are a good choice for individuals who wish to benefit from their bodies being in nutritional ketosis but do not want to follow extremely strict ketogenic diets.
Additionally, other ingredients like medium-chain triglycerides (MCTs) and electrolytes are commonly added to BHB Keto Gummies in order to support keto state and promote better performance during exercise. MCTs are easily converted into the liver that is responsible for production of ketones while electrolytes help maintain water balance that is important when a person is in the state of ketoacidosis.
Bhb Keto Gummies Frequently Asked Questions
Q: Can I use BHB Keto Gummies?
A: Generally, people can safely use BHB Keto Gummies so long as they follow instructions from manufacturer. However before starting any new supplement program especially if you have or if you are pregnant or nursing, it is always recommended that you consult with medical professional.
Q: How Should I Use Bhb Keto Gummies On A Ketogenic Diet?
A: Sometimes energy boosting may be needed to improve mental focus so as to achieve target weight loss rates while on keto. For optimal results, one should take them according to manufacturer’s instructions in combination with a balanced diet as well as regular exercise.
Q: Will Bhb Keto Gummies Help Me Lose Weight?
A: Despite, this BHB Keto Gummies product can help with weight loss through putting the body into ketosis state; it is not an instant solution for losing weight. To obtain the best outcomes, BHB Keto Gummies should be taken along with a well-balanced diet, physical exercise as well as a healthy lifestyle to maintain ideal body size and shape.
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With the increasing popularity of GLP-1 use for weight loss, I want to share some critical advice.
First & foremost, I don’t believe GLP-1s are for everyone, but those that use this tool shouldn’t be ashamed to ask for help because there cannot be one without the other, you must make take the proper steps to change your lifestyle. And I see many ppl struggling
Without support.
GLP1s can free up space in your brain. The food noise quiets & the scale finally moving.
They can also come with side effects - nausea, slowed digestion and fatigue.
Here are the 4 things I would not do if I were on a GLP1 for weight loss.
1. Eat processed or “fast” food. The way these drugs work is to keep your blood sugar from spiking. When you eat foods that are high in sugar or chemicals your body wants these foods out- by any means necessary. It is imperative that you eat a diet high in whole food nutrition. Nothing fried, fast or fatty.
2. Guess my protein intake. When it comes to hitting your protein goal, this should be your #1 priority. As with all extreme calorie restriction, you can easily lose weight in muscle. You need to keep your protein intake up so your body is ridding itself of fat, not muscle.
3. Skip my strength training workouts. Speaking of lean muscle mass, strength training is the best thing women can do for longevity & our metabolism. Not only will your strength grow, but lean muscle mass is what burns up stored fat!
4. Try to go about this alone. Many people think GLPs are a miracle- & maybe for some they are, but you still need guidance & accountability to build healthy sustainable habits. I don’t want you sick- I want you healthy, educated and empowerd!
Comment ME below or message me the word “SHOT” and let me show you how!
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Are you eating in a calorie deficit but still not losing weight? You’re not alone. In this video, I break down the top 3 reasons why your fat loss has stalled, even when you’re doing everything “right.”
If you’re a high-level desk worker or six figure professional trying to drop 20+ lbs, burn stubborn belly fat, and fit into your favorite clothes again, this is a must-watch.
I’ll show you the common mistakes I see busy professionals make all the time:
• Not tracking calories correctly
• Eating too little protein
• Not incorporating resistance training
These 3 simple shifts can make the difference between spinning your wheels and finally seeing the scale move in the right direction.
If you feel like you’re stuck and frustrated even while being in a calorie deficit, this video will help you reset, refocus, and start making real progress.
Subscribe for fat loss tips, high protein meal ideas, and sustainable strategies for busy desk workers who want to stay lean for life.
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Losing extra body fat with a mini cut to lean out before vacation! #highprotein #protein #fok
