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Novo Nordisk is Europe’s most valuable company with booming demand for its blockbuster diabetes and obesity drugs, Ozempic and Wegovy. They’re revolutionizing the weight loss drug industry, with some analysts predicting it could be worth up to $150 billion a year. Social media like TikTok and celebrities have helped their popularity soar. But it's not without controversy, including possible side effects and high prices. On the latest episode of Leaders with Lacqua, Francine Lacqua travels to the firm’s headquarters in Copenhagen, Denmark. She speaks to chief executive, Lars Fruergaard Jørgensen, about how he’s navigating the company’s meteoric rise and the sweeping changes its products could bring across a range of industries.
00:00 - Intro
02:00 - Novo Nordisk CEO Lars Fruergaard Jørgensen on Ozempic, Wegovy, diabetes, obesity
05:00 - Novo Nordisk CEO Lars Fruergaard Jørgensen on eating habits, social media, celebrities
08:50 - Novo Nordisk CEO Lars Fruergaard Jørgensen on prices, US investments, acquisitions
15:00 - Novo Nordisk CEO Lars Fruergaard Jørgensen on Covid, pandemic, vaccines
17:10 - Novo Nordisk CEO Lars Fruergaard Jørgensen on CEO leadership, corporate culture, advice
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GLP-1 agonists are not only for weight loss but also for patients with diabetes. Anne Peters, MD, discusses the importance of monitoring dosing between insulin and GLP-1 agonists.
https://www.medscape.com/viewarticle/997976?src=soc_yt
-- TRANSCRIPT --
We've all been hearing about the weight loss benefits of glucagon-like peptide 1 (GLP-1) receptor agonists, but it's important to remember that they are also diabetes medications. If you have a patient who's on an insulin secretagogue and/or insulin, it's important to remember that you need to adjust those medications to avoid hypoglycemia as you start and uptitrate the GLP-1 receptor agonist.
This isn't really cookbook, in the sense that you have to think about each patient, but I'll tell you what I do. First, I try to have most of my patients on continuous glucose monitors (CGM) because if they're on CGM, I can look at the trends to see what's happening as I'm adding a GLP-1 receptor agonist. If they're not on CGM, it's helpful if they test a fasting glucose level and perhaps a postprandial, though it's harder to get people to do, because you want to know whether to reduce the basal insulin or the prandial insulin.
Regardless of testing, you need to review with the patient the signs and symptoms of hypoglycemia and how to treat it if it occurs. In a patient on insulin, you may want to make sure they have glucagon at home because there have been episodes of severe hypoglycemia when a GLP-1 receptor agonist was added to insulin.
As a rule of thumb, I start by looking at the A1c. If the A1c is above 8%, I'm probably not going to do much reduction in the insulin secretagogue or the insulin right off the bat. I'll watch the patient as they begin to respond to the GLP-1 receptor agonist and then start tapering down the insulin if their glucose levels fall.
I often reduce the prandial insulin levels first because you're going to start seeing the patient eating less and be at increased risk for hypoglycemia between meals. If I start seeing the fasting glucose fall, then I'll start reducing the basal insulin. Usually, I reduce the doses by 10%-20%.
As I said, in somebody who starts out with a higher A1c, I don't right off the bat reduce the insulin. I watch what happens as the dose is increased. As the dose is increased in someone who's on an oral insulin secretagogue, I'll tend to cut that dose in half as I see glucose levels coming down.
On the other hand, if someone's starting A1c is below 8%, I might start by reducing their prandial insulin by 50% and maybe their basal insulin by 10%-20%, depending on their glucose levels. I think patients who are closer to target on insulin and/or a sulfonylurea agent are going to be at increased risk for going low.
Ideally, one can taper the patient off their insulin — and if not entirely off their insulin, off their prandial insulin — because it's much easier to give basal insulin and a once-weekly GLP-1 receptor agonist than to be on a multiple daily insulin regimen. Potentially, you'll be able to taper your patient off their insulin secretagogue as well.
The important thing to remember is that there's more than one moving target. You're uptitrating the GLP-1 receptor agonist or the GIP/GLP-1 receptor agonist and you're downtitrating the insulin secretagogue and/or the insulin. You want to downtitrate in gradual steps to keep ahead of any risk for hypoglycemia. Usually, that is done in slow steps, say, 10%-20% at a time.
It also means that you pay attention to your patients and that you may need to follow them every week or two, particularly if their A1c starts out below 8%, where they're likely to be at more risk for hypoglycemia.
If you pay attention to this process, you should be able to get your patient to a better point, hopefully on less medication that can cause hypoglycemia, and onto a medication that not only improves glucose but also helps with weight reduction, improves cardiovascular outcomes, and may have a renal benefit.
Thank you.
https://www.medscape.com/viewarticle/997976?src=soc_yt
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Take two capsules daily with water before meals. Consistency is key, so ensure you follow the routine for the best results.
LipoZem Customer Reviews
Jessica M.: "I’ve lost 15 pounds in just a month with Lipozem! It curbs my appetite and keeps me energized."
Carlos D.: "I was skeptical, but this really worked for me. It helped me lose weight without feeling jittery."
Anna P.: "I saw results within the first few weeks. My cravings are gone, and I feel lighter!"
Mark H.: "Lipozem helped me break through my weight loss plateau."
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Conclusion
Lipozem is an excellent option for those who want to lose weight naturally. With ingredients that promote metabolism and help control appetite, this supplement offers a safe solution to achieve your slimming goals faster.
00:01 - LipoZem Review
00:28 - What is LipoZem?
01:00 - LipoZem Supplement
01:28 - LipoZem Benefits
01:58 - LipoZem Ingredients
02:19 - Does LipoZem Work?
02:44 - LipoZem Official Website
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We’ll learn how to stop emotional eating, how to build a healthy relationship with food, and how to eat mindfully. You’ll learn why eating slowly, staying hydrated, and walking daily can create a major difference in your journey. If you’re looking for easy weight loss tips that don’t include exercise or gym memberships, I have got you covered. These small changes can help you feel lighter, more energized, and confident in your body—without feeling restricted.
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˚.🎀༘⋆
Timestamps:
0:00 Intro
0:31 Eat slowly
0:57 Eat until you’re 80% full
1:27 Drink water before meals
1:58 Don’t skip meals
2:21 Start meals with veggies or salad
2:50 Only eat when you’re truly hungry
3:18 Use smaller plates
3:39 Cut out sugary drinks
4:05 Focus on whole, real foods
4:33 Stay hydrated all day
5:01 Stop eating 2–3 hours before bed
5:25 Watch out for hidden sugars
5:51 Keep a food journal
6:17 Plan your meals & snacks
6:45 Walk 1 hour daily
7:40 Outro
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Are you tired of sacrificing your favorite treats while following a keto diet? Look no further than Let’s Keto Apple Gummies! These sweet apple-flavored gummies are the perfect way to satisfy your sweet tooth while staying on track with your keto lifestyle. Packed with keto-friendly ingredients and delicious apple flavor, these gummies are a must-have for anyone looking for a tasty snack that supports their keto goals.
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