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http://www.DoctorsToTrust.com
presents episode 2205 | DR BEN BIKMAN
Dr Ben Bikman's dissertation work done in first GLP-1 lab
in gastric-bypass procedures--as guts were re-plumbed,
led to profound differences in GLP-1
-many gut hormones were changed with this surgery
-GLP-1 is a natural hormone made by intestines
Endocrine organs: thyroid, adrenals, gonads
Brain , heart, muscle, bone makes hormones
GLP-1 agonist: drug that, when injected, dials up GLP-1
signal to a superphysiological level…
-early on in this drug testing, the dose was low, and it:
-only inhibited glucagon [opposite effect of insulin]
-quick and substantial drop in blood glucose
-resolving T2D quite well
-and, as little side effect, people ate a little less
Now: at 5X dose: used as weight loss drug:
Paralysis of the Intestines--main action
-food stays in stomach 24+ hours
GLP-1 is a metabolic advantage...we want it
-protein intake will increase it; fat intake will increase it
-some carbs do; so does fiber [stimulate L cells that make it]
Can take advantage of GLP-1's satiety effect due to
slowing down digestion
Problem with these drugs: Slows Down Digestion Too Much
-in some cases: permanent paralysis of intestines
-must get nutrition thru infusion Rest of Life
-and have colostomy bag
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original video interview: https://youtu.be/_krZOM4Zc3c?si=5agpNIgP4qg_Cnm-
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