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Obesity expert Dr Holly Lofton reviews three alternatives to GLP-1s to help patients drop excess weight. https://www.medscape.com/viewarticle/1000474?src=soc_yt -- TRANSCRIPT -- Hi. I'm Dr Holly Lofton. I'm a board-certified obesity medicine specialist, and I direct the medical weight management program at NYU Langone Health. There is so much information about glucagon-like peptide 1 (GLP-1) agonists as anti-obesity medications. I bet you can't think of a single person who hasn't heard of them, and many of your friends or family members may have even tried them. However, we also have what we call the first generation of medications for weight management, and I'll talk about some of those today. Phentermine. If your patient is not able to tolerate a GLP-1 agonist or is unable to access these medicines for various reasons, one option is phentermine, which has been around for decades. It is an oral medication that's usually taken once a day in the morning. It is a classic appetite suppressant. Phentermine makes people feel less hungry. It also gives people a little more energy, so they're able to increase their activity while creating a caloric deficit, and this leads to weight loss over time. Phentermine differs from the GLP-1 agonists, which are intended for chronic weight management. The FDA has approved phentermine for short-term weight loss; its use is recommended for no more than 12 weeks at a time. The medication comes in doses ranging from 8 mg to 37.5 mg and is usually slowly titrated up depending on tolerance and effect. Side effects that are most often reported include a racing heart, insomnia, agitation, and dry mouth. This drug is not for everyone. Phentermine is contraindicated in those with uncontrolled hypertension, with cardiac disease (such as a history of heart attack), or who are at high risk for heart attack or stroke. Some drug interactions can occur, which should be considered on a case-by-case basis. Phentermine may be an option for your patients if an elevated appetite is keeping them from losing weight. It should be used as an adjunct to lifestyle recommendations, which means eating fewer calories and increasing activity. Phentermine-Topiramate. Another non–GLP-1 agonist medication indicated for obesity is phentermine-topiramate [Qsymia]. This is another oral medication. The idea behind combining these two medications is that they can generate more appetite suppression without the high potential for side effects of phentermine alone, such as agitation, increased heart rate, or increased blood pressure. Topiramate is used for migraine or seizure prevention. One side effect of topiramate is unintentional weight loss, so they decided to combine phentermine with topiramate in one pill. Phentermine-topiramate comes in four different doses and is usually titrated up from the lowest to the highest dose. People who can't tolerate the higher doses of phentermine are able to tolerate Qsymia because the dose of phentermine is lower. This medication came to the market in 2012, after the SEQUEL trial, which demonstrated its safety and efficacy, achieved about 12% weight loss, which for many years was the highest weight loss seen with any other anti-obesity medications on the market. Because this is a combination medication, it has some potential side effects and contraindications. For example, we don't give phentermine-topiramate to people with uncontrolled hypertension or anxiety, and it is contraindicated in those with glaucoma. We don't give this medication to anyone who has had adverse reactions or hypersensitivity to either of the ingredients. Because the combination contains topiramate, it should not be prescribed to anyone with childbearing potential unless they are using an effective form of hormonal contraception or even two effective forms. Topiramate can increase the risk of having a baby with a cleft palate by five times if they become pregnant while taking this medication. Phentermine-topiramate is dosed once daily. One commonly reported side effect is paresthesia: numbness and tingling of the fingers and toes that can manifest as feeling very cold when it's cold outside. Although some patients report paresthesia, most say that it's not so intolerable that they want to discontinue the medication. There have been reports of vision changes in people taking phentermine-topiramate; if severe vision changes occur, it is recommended to discontinue the medication. Transcript in its entirety can be found by clicking here: https://www.medscape.com/viewarticle/1000474?src=soc_yt

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When it comes to weight loss, many people turn to fat burner supplements to help them achieve their goals. With so many options on the market, it can be overwhelming to choose the best fat burner supplement for your needs. It’s important to do your research and consider factors such as ingredients, dosage, and potential side effects before making a decision. In this article, we will discuss how to select the best fat burner supplement to help you elevate your weight loss journey.

Understanding Fat Burner Supplements

Fat burner supplements are designed to help increase fat metabolism, boost energy levels, and suppress appetite. They often contain a mixture of ingredients such as caffeine, green tea extract, and L-carnitine, which have been shown to promote weight loss. These supplements can be a useful tool for those looking to shed excess pounds, but it’s essential to choose a high-quality product to ensure safety and effectiveness.

When selecting a fat burner supplement, it’s essential to consider the ingredients used in the formula. Look for supplements that contain proven fat-burning ingredients such as green tea extract, caffeine, and Capsimax, a natural thermogenic ingredient derived from hot peppers. These ingredients have been shown to increase metabolism and promote fat loss when combined with a healthy diet and exercise regimen.

In addition to ingredients, it’s crucial to consider the dosage of the fat burner supplement. Some products may contain high levels of stimulants, which can cause jitteriness, headaches, and other side effects. Start with a low dose and gradually increase as needed, following the manufacturer’s recommendations. It’s also essential to be mindful of other sources of caffeine in your diet, as too much can lead to unwanted side effects.

Researching the Best Fat Burner Supplement for You

Before purchasing a fat burner supplement, take the time to research different products and read reviews from other users. Look for reputable brands that have been tested for quality and safety. Consider speaking with a healthcare provider or nutritionist to get personalized recommendations based on your individual needs and health goals.

When selecting a fat burner supplement, it’s essential to consider your specific weight loss goals and lifestyle. Some supplements are designed to boost energy levels, making them ideal for those who need an extra push during workouts. Others may focus on suppressing appetite, which can be beneficial for those who struggle with overeating. Choose a supplement that aligns with your weight loss goals and preferences to maximize results.

Finally, it’s essential to approach fat burner supplements as a complement to a healthy diet and exercise routine. While these supplements can help accelerate weight loss, they are not a magic solution. Focus on making sustainable lifestyle changes and incorporating good nutrition and regular physical activity into your daily routine. Remember that consistency is key when it comes to achieving long-term weight loss success.

Conclusion

Choosing the best fat burner supplement for your weight loss journey requires careful consideration of ingredients, dosage, and personal preferences. By doing your research, consulting with healthcare professionals, and prioritizing a healthy lifestyle, you can elevate your weight loss results and achieve your goals more efficiently. Remember that these supplements are meant to support, not replace, a balanced diet and regular exercise routine. With the right approach, you can find a fat burner supplement that helps you reach your weight loss goals and improve your overall health and well-being.

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Do I Need Butyrate Supplements On Keto? In this informative video, we explore the role of butyrate in relation to the ketogenic diet and its impact on gut health. Butyrate, a short-chain fatty acid, plays a vital role in maintaining a healthy gut lining and reducing inflammation. While the ketogenic diet is high in fats and low in carbohydrates, it can sometimes lead to lower production of butyrate due to a decrease in fiber-rich foods. In this video, we discuss how you can support butyrate production through dietary choices, including the incorporation of fiber-rich and fermented foods into your meals. We will also cover the benefits of butyrate for those following a ketogenic lifestyle, including its ability to help manage inflammation and serve as an energy source for gut cells. If you’ve been wondering whether butyrate supplements are necessary, we’ll provide guidance on when they might be beneficial, especially for those struggling to consume enough fiber or experiencing gut health challenges. Join us as we navigate the relationship between butyrate and the ketogenic diet, and subscribe to our channel for more helpful tips and information on optimizing your health through diet. ⬇️ Subscribe to our channel for more valuable insights. 🔗Subscribe: https://www.youtube.com/@KetoKitchenHQ/?sub_confirmation=1 #KetoDiet #Butyrate #GutHealth #ShortChainFattyAcids #Fiber #Inflammation #MetabolicHealth #FermentedFoods #HealthyEating #KetoLifestyle #WeightManagement #KetoSupplements #NutritionTips #GutHealthSupport #DietaryFiber About Us: Welcome to Keto Kitchen HQ, your go-to channel for everything related to the keto diet. Whether you're a beginner looking to understand Keto Diet Basics or an experienced practitioner refining your approach, we cover a range of topics including Low-Carb Meal Planning, Ketosis Explained, and Keto-Friendly Foods. Our engaging videos will help guide you on your journey with insights into Intermittent Fasting, Keto for Weight Loss, and delicious Ketogenic Recipes.

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