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Pfizer on Friday said it would stop developing the twice-daily version of its experimental weight loss pill after obese patients taking the drug lost weight but had trouble tolerating the drug in a mid-stage clinical study. The drugmaker observed high rates of adverse side effects, which were mostly mild and gastrointestinal, among patients. A significant share of patients also stopped taking the drug in the trial."At this time, twice-daily danuglipron formulation will not advance into Phase 3 studies," the company said. But Pfizer said it still plans to release phase two trial data on a once-a-day version of the drug in the first half of 2024, which will "inform a path forward." The pharmaceutical giant will wait to see that data before deciding whether to start a phase three study on the once-daily pill, which Wall Street views as the more competitive form of the treatment. Still, the data on the twice-daily drug is a blow to Pfizer's hopes to win a $10 billion slice of the booming weight loss drug market, which CEO Albert Bourla has said could grow to $90 billion. The company is betting on a successful weight loss pill to help it rebound from plummeting demand for its Covid products and a roughly 40% share price drop this year. But investors have been pessimistic about Pfizer's potential in the weight loss drug space since the company scrapped a different once-daily pill in June and proceeded with the less attractive danuglipron. Now, Friday's data puts Pfizer even further behind the dominant players in the weight loss drug market, Eli Lilly and Novo Nordisk, which are racing to develop more convenient pill versions of their blockbuster weight loss and diabetes injections. Pfizer's phase two trial on its twice-daily pill followed around 600 obese adults who did not have Type 2 diabetes. The trial examined the drug's effect on weight loss after 26 or 32 weeks, at different dosage amounts ranging from 40 milligrams to 200 milligrams. Like Novo Nordisk's Wegovy and Ozempic, Pfizer's pill works by mimicking a hormone produced in the gut called GLP-1, which signals to the brain when a person is full. All dose sizes of Pfizer's pill showed "statistically significant reductions" in body weight ranging from 6.9% to 11.7% at 32 weeks, and from 4.8% to 9.4% at 26 weeks. Meanwhile, patients on a placebo lost 8% to 13% of their body weight at 32 weeks and 5% to 9.5% at 26 weeks, Pfizer said. The company said high rates of adverse events were observed among patients in the study, with up to 73% experiencing nausea, up to 47% vomiting and up to 25% experiencing diarrhea. More than 50% of patients across all dose sizes stopped taking the pill, compared to roughly 40% among those on the placebo, according to Pfizer. No new safety issues were observed, and danuglipron was not associated with increased liver enzymes like Pfizer's other discontinued weight loss pill. All data is taken from the source: http://cnbc.com Article Link: https://www.cnbc.com/2023/12/01/pfizer-to-discontinue-twice-daily-version-of-weight-loss-pill.html #weight #newshour #newstodayheadlines #newstodayfox #newstodayupdate #newstodayworld #

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Introduction

Lainey Wilson has captured the hearts of country music fans with her soulful voice and relatable lyrics. As an artist on the rise, she has become a prominent figure in the music industry, but her journey has extended beyond her music career. Recently, Lainey has made headlines for her significant weight loss, which she achieved through natural methods. This article delves into her transformation, exploring the strategies she employed to shed pounds, her motivations behind the change, and how her approach can inspire others on similar journeys.

Weight loss is often a complex subject, particularly in an industry where image and aesthetics are foregrounded. Lainey Wilson, however, has approached her weight loss journey with a refreshing candor that resonates with many. Her decision to lose weight was driven not only by aesthetics but also by health reasons and a desire for a higher quality of life. As she embarked on her journey, Lainey explored various natural methods and lifestyle changes, which she has openly shared with her fanbase, encouraging them to pursue healthy living without succumbing to restrictive diets or extreme fitness regimens.

This article will outline the key aspects of Lainey’s weight loss journey, focusing on her nutrition, exercise, mindset, and the support systems that played crucial roles in her transformation. By understanding her approach, readers can extract valuable lessons applicable to their own lives. Moreover, Lainey’s story serves as a reminder that weight loss is not solely about numbers on a scale, but about embracing a healthier lifestyle and fostering a positive relationship with one’s body. Through her journey, Lainey has become a beacon of hope for those seeking change, showing that natural and sustainable weight loss is, indeed, attainable.

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Nutritional Changes: Eating for Wellness

One of the most significant shifts Lainey made on her weight loss journey was in her approach to nutrition. She began by reevaluating her eating habits, focusing on nourishing her body rather than simply cutting calories. Lainey integrated more whole foods into her diet, including fruits, vegetables, lean proteins, and whole grains. This change was fundamental in helping her shed pounds while ensuring she received the essential nutrients needed for her energy levels and overall well-being.

Lainey also embraced the concept of mindful eating, which encouraged her to pay attention to her hunger cues and food choices. By being fully present during meals, she learned to enjoy her food more and avoid emotional eating, which can be a significant barrier in any weight loss journey. This heightened awareness led her to make better food choices, which not only supported her weight loss goals but also improved her relationship with food.

Additionally, Lainey explored meal prepping as a proactive approach to maintaining her new lifestyle. By preparing healthy meals in advance, she could avoid the temptation of fast food or unhealthy snacks during busy days. This commitment to her nutritional health played a vital role in her weight loss, setting her up for success and keeping her motivated throughout her journey.

Exercise: Moving with Purpose

Complementing her dietary changes, Lainey also dedicated time to incorporate physical activity into her routine. She began by engaging in exercises she genuinely enjoyed, which made the process enjoyable rather than a chore. Whether it was dancing, hiking, or yoga, Lainey’s emphasis on finding pleasure in movement transformed exercise from a daunting task into a source of joy and release.

The importance of consistency cannot be overstated in Lainey’s journey. By establishing a regular workout schedule, she created healthy habits that became second nature. This consistency wasn’t about intense workouts every day; rather, it focused on making movement a regular part of her life, encouraging her to stay active while balancing her busy schedule as a musician.

Lainey also recognized the importance of rest and recovery in her fitness routine. Understanding that over-exercising can lead to burnout, she made it a point to listen to her body and allow adequate recovery time. This holistic approach ensured her physical well-being, reducing the risk of injury and keeping her motivated to continue her journey.

Mindset Matters: Building a Positive Body Image

At the core of Lainey Wilson’s weight loss journey is the powerful shift in her mindset toward body image and self-love. Lainey openly shares that embracing her body at every stage was crucial for her mental health. This positive mindset helped her navigate the challenges and setbacks that often accompany a weight loss journey, allowing her to stay focused on her long-term goals instead of becoming disheartened by temporary obstacles.

Confidence plays a significant role in how one perceives their body. For Lainey, learning to appreciate her body for what it could do, rather than merely how it looked, transformed her outlook on health and fitness. This intrinsic motivation—to honor her body through nourishing foods and physical activity—helped her create a sustainable lifestyle that she could maintain over time.

Moreover, Lainey has been a source of inspiration to many who struggle with body image issues. By openly discussing her experiences and challenges, she has fostered a community of support among her fans, encouraging them to love themselves unconditionally. Her message of self-acceptance and resilience strikes a chord with many, reminding them that weight loss is about more than appearances; it’s about overall well-being and self-worth.

Support Systems: The Power of Community

Every weight loss journey is unique, yet one common factor among successful transformations is the support system that surrounds individuals. Lainey Wilson recognized the importance of community support in her journey. She openly credits her friends, family, and fans for their encouragement and motivation, which proved invaluable as she worked towards her weight loss goals.

Sharing her experiences on social media, Lainey has created a platform for interaction and connection, allowing her fans to engage with her journey. This online community became a space for sharing tips, challenges, and triumphs, reinforcing the idea that one does not have to embark on a weight loss journey alone. By fostering this sense of community, Lainey found accountability and encouragement from others who resonated with her goals.

Moreover, Lainey found allies in her professional network, including trainers and nutritional experts, who provided additional guidance during her transformation. Seeking professional advice allowed her to gain insights tailored to her unique circumstances, further enhancing her chances of success. This holistic support network became a pivotal part of her weight loss journey, demonstrating how crucial it is to surround oneself with individuals who uplift and motivate.

Summary: Lessons Learned from Lainey Wilson’s Journey

Lainey Wilson’s weight loss journey serves as an inspiring blueprint for those looking to embark on a similar path. Her approach is refreshingly grounded in natural methods, emphasizing nutrition, exercise, mindset, and community support. By focusing on whole foods and the joy of movement, Lainey has not only transformed her body but has also cultivated a healthier relationship with herself.

The lessons learned from Lainey’s journey highlight the importance of a positive mindset, acknowledging that self-love and acceptance are significant components of lasting change. Her story resonates with anyone struggling with body image or weight loss, encouraging them to prioritize their well-being over societal expectations. It illustrates that weight loss is not merely a physical transformation but a holistic journey toward embracing health, happiness, and self-acceptance.

Ultimately, Lainey Wilson’s journey is a testament to the power of living authentically, embracing one’s true self, and prioritizing health through conscious lifestyle choices. Her willingness to share her experience empowers others to pursue their journeys with confidence and resilience. By taking small, sustainable steps and building a supportive community, anyone can embark on a transformative path toward their best selves. Lainey’s story is proof that weight loss can be a beautiful journey, filled with growth, learning, and self-discovery.

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