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In this “Ask Me Anything” (AMA) episode, Peter focuses the discussion on two topics getting a lot of attention recently. He first dives deep into GLP-1 agonists, most notably semaglutide and tirzepatide, which originally came to market as diabetes drugs but are now being studied and prescribed for weight loss. He walks through the data and compares the effectiveness of the two drugs, the side effects, and perhaps more importantly, his reservations around wide use of these drugs and who he would consider to be a candidate for them. Next, Peter discusses how metformin, another drug originally brought to market for diabetes management, gained popularity as a potential longevity drug even for non-diabetics. Peter gives his take on this possibility and reviews data from a more recent study investigating the question of whether metformin should be used for general “geroprotection.”
In this sneak peek, we discuss:
00:00 - Intro
00:08 - The hype around semaglutide, tirzepatide, and other GLP-1 agonists for weight loss
04:09 - Overview of GLP-1 agonists and why these drugs are getting so much attention
12:20 - Defining the term “geroprotective”
14:08 - Semaglutide: background, brand names, indications, and more
19:10 - Tirzepatide: background, brand names, indications, and more
In the full episode, we also discuss:
-How semaglutide and tirzepatide compare in their efficacy in terms of weight loss and other metabolic health metrics;
-Data showing sustained weight loss and improved metabolic metrics with after more than a year of using semaglutide and tirzepatide;
-What happens to body weight when a patient discontinues the medication?;
-Noteworthy side effects of GLP-1 agonists and similar classes of drugs;
-Increased resting heart rate and other concerning trends in patients using GLP-1 agonists;
-Changes in body composition (body fat and lean muscle) in patients on GLP-1 agonists;
-Possible reasons for the loss of lean muscle mass and tips for protecting lean mass;
-GLP-1 agonists and thyroid cancer;
-Who might be a candidate for GLP-1 agonists?;
-The large financial cost of this class of drugs;
-Metformin as a geroprotective drug: origin of the idea that metformin could be a longevity agent even for non-diabetic patients;
-A 2022 study on metformin sheds more light on the question of whether metformin should be used for “geroprotection” in non-diabetics;
-Peter’s current approach with metformin for his patients; and
-More.
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About:
The Peter Attia Drive is a weekly, ultra-deep-dive podcast focusing on maximizing health, longevity, critical thinking…and a few other things. With over 45 million episodes downloaded, it features topics including fasting, ketosis, Alzheimer’s disease, cancer, mental health, and much more.
Peter is a physician focusing on the applied science of longevity. His practice deals extensively with nutritional interventions, exercise physiology, sleep physiology, emotional and mental health, and pharmacology to increase lifespan (delay the onset of chronic disease), while simultaneously improving healthspan (quality of life).
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Disclaimer: This podcast is for general informational purposes only and does not constitute the practice of medicine, nursing, or other professional healthcare services, including the giving of medical advice. No doctor-patient relationship is formed. The use of this information and the materials linked to this podcast is at the user's own risk. The content on this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they have, and they should seek the assistance of their healthcare professionals for any such conditions. I take conflicts of interest very seriously. For all of my disclosures and the companies I invest in or advise, please visit my website where I keep an up-to-date and active list of such companies.
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Alissa, our go-to health expert, explains her trifecta for losing weight which is, cardio, weightlifting, and nutrition. Incorporating these three things into your life will help you lose weight. If you are focused on gaining muscle it actually helps burn fat while you are resting.
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There has been a lot of excitement in the medical community around the use of semaglutide for weight loss. Semaglutide is a medication originally developed to treat type 2 diabetes, but recent studies have shown that it can also be highly effective in helping people lose weight. However, finding the optimal dose of semaglutide for weight loss can be a complex process. In this article, we will explore the different factors that can impact the ideal dosage of semaglutide, and how healthcare providers can work with patients to find the right amount for their individual needs.
Understanding Semaglutide for Weight Loss
Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist, which means that it works by mimicking the effects of a hormone called GLP-1 in the body. GLP-1 is naturally released in response to food consumption and helps regulate blood sugar levels, increase feelings of fullness, and slow down digestion. By acting like GLP-1, semaglutide can help control appetite and promote weight loss.
Studies have shown that semaglutide can lead to significant weight loss in people with obesity, even in the absence of diabetes. In fact, some clinical trials have demonstrated weight loss of up to 15% of initial body weight in participants who took semaglutide. This has made semaglutide an attractive option for people struggling to lose weight through diet and exercise alone.
One of the key benefits of semaglutide for weight loss is its once-weekly dosing schedule. This can make it more convenient for patients compared to other weight loss medications that may require multiple daily doses. However, finding the right dose of semaglutide is crucial to achieving optimal weight loss results while minimizing potential side effects.
Factors Affecting Semaglutide Dosage
There are several factors that can influence the ideal dosage of semaglutide for weight loss. One of the most important considerations is the patient’s starting weight and overall health. People with higher body mass indexes (BMIs) or more severe obesity may require higher doses of semaglutide to achieve significant weight loss.
Another factor to consider is the patient’s response to the medication. Some individuals may experience greater weight loss with lower doses of semaglutide, while others may require higher doses to see results. Healthcare providers will need to monitor patients closely to determine how they are responding to treatment and make adjustments to the dosage as needed.
It is also important to take into account any potential side effects of semaglutide when determining the optimal dose. Common side effects of semaglutide for weight loss can include nausea, vomiting, diarrhea, and constipation. These side effects may be dose-dependent, so finding the right balance between efficacy and tolerability is essential.
Optimizing Semaglutide Dosage for Weight Loss
When starting treatment with semaglutide for weight loss, healthcare providers will typically begin with a lower dose and gradually increase it over time. This allows patients to adjust to the medication and gives providers the opportunity to assess how the patient is responding. The goal is to find the lowest effective dose that produces the desired weight loss results with minimal side effects.
Patients should work closely with their healthcare providers to track their progress and communicate any concerns or changes in symptoms. This can help ensure that the dosage of semaglutide is optimized for each individual’s unique needs. It may take some trial and error to find the right dose, but with patience and perseverance, many patients can achieve significant weight loss with semaglutide.
Conclusion
Semaglutide has shown great promise as a medication for weight loss, with studies demonstrating significant reductions in body weight for many participants. Finding the optimal dose of semaglutide for weight loss can be a nuanced process, influenced by factors such as starting weight, response to treatment, and potential side effects. By working closely with healthcare providers and staying vigilant in monitoring progress, patients can maximize the benefits of semaglutide while minimizing any negative effects. With continued research and clinical experience, semaglutide may prove to be a valuable tool in the fight against obesity and its associated health risks.
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