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Gear, Growth, and Gains Ep. 014 Peptide Reconstitution Demystified, Emerging Data on Combined GLP-1 Agonists and Myostatin Inhibitors, Oral Steroids and the Heart, and Coach's Corner - Training Volume Myths Show Time 32 min, 26 sec Show Notes and Description In episode 14 of "Gear Growth and Gains," Type-IIx discusses evidence-based practices in enhanced bodybuilding. He debunks myths about peptide reconstitution, emphasizing normal saline as the optimal solvent. The episode reviews emerging clinical data on combining GLP-1 agonists with myostatin inhibitors for improved muscle retention during weight loss. Type-IIx explains why oral 17 alpha-alkylated steroids pose greater cardiovascular risks than injectables due to their effects on lipid metabolism. Finally, he clarifies that excessive training volume impairs hypertrophy, stressing the importance of quality, intensity, and recovery for muscle growth. Outline and Timestamps Introduction and Episode Overview (00:00:30) Type-IIx introduces the podcast, outlines the four main topics, and provides disclaimers and promotional info. Peptide Reconstitution: Myths and Best Practices (00:02:56) Explains misconceptions about peptide reconstitution, debunks bro science, and emphasizes normal saline as the best solvent. History of Bro Science in Peptide Use (00:04:07) Describes the origins of peptide reconstitution myths in early bodybuilding forums and how misinformation spread. NAD+ and Solvent Confusion (00:06:33) Discusses the rise of NAD+ injections, their ineffectiveness, and confusion about which solvents to use. Normal Saline vs. Bacteriostatic Water (00:08:02) Clarifies why normal saline is preferred for reconstitution, and addresses misconceptions about bacteriostatic water. Properties and Safety of Normal Saline (00:09:05) Explains what normal saline is, its isotonic properties, and why it’s safe and widely used. Risks of Bacteriostatic Water and Solvent Regulation (00:10:24) Compares the risks of homemade bacteriostatic water to normal saline and explains regulatory reasons. GLP-1 Agonists and Myostatin Inhibitors: New Data (00:11:32) Introduces the COURAGE trial and the rationale for combining GLP-1 agonists with trevogrumab. Strategies to Preserve Muscle on GLP-1 Drugs (00:12:38) Outlines three strategies to maintain muscle while using GLP-1 drugs, focusing on drug interventions. Myostatin Inhibitors: Mechanisms and Trials (00:13:48) Reviews the history, mechanisms, and clinical trials of myostatin inhibitors, including new combination therapies with trevogrumab. COURAGE Trial Results and Drug Synergy (00:14:59) Details the COURAGE trial’s experimental groups, results, and the synergy of combining the myostatin inhibitor trevogrumab with GLP-1 drugs. Molecular Pathways in Muscle Growth (00:15:59) Explains the molecular signaling pathways involved in muscle growth and how different drugs interact. Safety and Side Effects of Myostatin/Activin-A Inhibitors (00:16:14) Discusses the safety profile of new myostatin inhibitors like trevogrumab and the side effects of anti-activin A drugs. Oral Steroids and Cardiovascular Risk (00:17:31) Explains why 17 alpha-alkylated oral steroids like Anavar are more harmful to heart health than injectables. Mechanisms of Steroid-Induced Dyslipidemia (00:18:47) Describes how oral steroids negatively affect lipid profiles and increase cardiovascular risk. Estrogen’s Protective Role and Specific Steroid Effects (00:20:08) Covers the protective effects of estrogen on lipids and why certain steroids are harsher on the heart. Summary: Why Some Steroids Are Safer for Lipids (00:21:20) Summarizes why Dianabol is less harsh on lipids and why Trenbolone is still risky despite being injectable. Book Promotion: Bolus Guide (00:21:20) Promotes the Bolus guide for practical bodybuilding drug protocols and research interpretation. Bloodwork and Lab Testing Recommendations (00:23:07) Recommends Fitomics for blood work and explains how to sign up for lab testing and newsletters. Coach’s Corner: Training Volume Myths (00:24:10) Explains why more sets, reps, or sessions are not better for muscle growth and can be counterproductive. Mechanisms of Hypertrophy and Recovery (00:25:25) Discusses the science of muscle growth, the importance of recovery, and the difference between strength and size. Effective Reps and Optimal Training Volume (00:26:35) Emphasizes the importance of effective reps, diminishing returns of excessive volume, and the inverse dose-response curve. Conclusion and Outro (00:26:35) Wraps up the episode and promises more regular content in the future. Topics Gear Growth and Gains, Meso-Rx, enhanced bodybuilding, peptide reconstitution, peptides, broscience, normal saline, GLP-1, trevogrumab, GLP-1 agonists, myostatin inhibitors, Courage trial, semaglutide, muscle retention, fat loss, oral steroids, cardiovascular risk, 17 alpha-alkylated steroid...
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Both GLP-1 medications are game-changers for weight loss & metabolic health, but Tirzepatide (Mounjaro) may have the edge! Here’s why: ✅ Semaglutide (Ozempic, Wegovy) – Targets GLP-1 receptors to improve insulin sensitivity & support weight loss (10-15% of body weight). ✅ Tirzepatide (Mounjaro) – A dual agonist that targets GLP-1 & GIP receptors, leading to greater metabolic benefits and potential 20% weight loss! 📖 Studies in The New England Journal of Medicine & The Lancet confirm these impressive results. Want to know which one might be right for you? Drop a 💊 in the comments & follow for more health insights! 👇 🎧 Listen to the full episode of the Rare Wellness Podcast with Dr. Jamie Lewis. Out Now!
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If you're using Ozempic (semaglutide) or Mounjaro (tirzepatide) for weight loss or type 2 diabetes, avoiding these common pitfalls is critical for your success. In this video, I break down the top 5 mistakes I see patients make while on GLP-1 medications — from dosing errors to diet misconceptions — and explain how to get the best results safely and effectively. Whether you're new to GLP-1s or already on your journey, this guide will help you stay informed and empowered. #ozempic #glp1weightloss #mounjaro #weightloss Timestamp: 00:00 - Introduction 00:17 - Wrong injection site 02:21 - Too many calories 03:08 - Not eating enough 05:21 - Electrolytes 06:31 - Increasing dose too soon 07:39 - Final thoughts If you're looking for even more information on GLP-1 agonists make sure to check out my other videos as well: My personal journey: https://youtu.be/LxSj3mfAoFA?si=2ujsn7sG02aSYzHh New to GLP-1 Agonists? Start here: https://youtu.be/EvC07wUmAvA?si=oxkhROy33FAaFrw8 Find out the best injection site location for GLP-1 Agonists: https://youtu.be/RMFifEo3lfw?si=2FH2eTGX3nyFciyb Learn more about microdosing GLP-1 Agonists: https://youtu.be/MA9KsoZOr3E?si=vVSedcsf28JU6KpO Trying to find the perfect dose? Learn how to use the GLP-1 Plotter here: https://youtu.be/I2Tush6FHOM?si=mR0I-DO-p1gN8snu
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