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On today’s pharmaphorum podcast, Dr. Tim Church, chief medical officer at digital weight loss clinic Wondr Health joins Editor in Chief Jonah Comstock to chat about these new drugs, how they work, and how they're changing the game for patients.
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Jelly Roll's Photos After His Weight Loss Are A Bit Too Much You’ve seen Jelly Roll’s incredible music career take off—but have you seen his recent weight loss photos? They’re causing quite a stir! In this video, we dive into the inspiring (and sometimes shocking) transformation of the country-rap star, exploring what motivated his dramatic change, the methods he used to shed the pounds, and why some fans are saying these new photos are “a bit too much.” Whether you’ve followed Jelly Roll since day one or are just discovering his music, you won’t want to miss the jaw-dropping before-and-after moments. **Don’t forget to like, comment, and subscribe** for more revealing stories about your favorite celebrities and personalities. Let’s explore Jelly Roll’s journey together!
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Doing core exercises to lose belly fat? That’s not how it works!🚫 You can’t spot-reduce body fat. Training a specific muscle won’t burn fat in that area. To lose belly fat, you need to be in a caloric deficit—eating fewer calories than you burn throughout the day. For men especially, belly fat can be stubborn because it’s where the body tends to store fat the longest. So, if you want to reveal that six-pack, staying consistent with your deficit is key! And remember, most ab circuits give you a good burn, but to build size, you need to train abs like any other muscle—by continuously overloading them. ➡️If you’re tired of all the BS and want someone who keeps it real—SUBSCRIBE for no-nonsense, straight-to-the-point content like this! 💯 #FitnessFacts #FatLoss #AbsWorkout #StayConsistent #CaloricDeficit
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The Future of Obesity Therapy and the Development of GLP-1 Drugs Today, we have Tirzepatide (brand names: Zepbound, Mounjaro) and Semaglutide (Ozempic, Wegovy). Who’s next? When will the next weight loss injection — or finally a weight loss pill — be released in the coming years? Let’s take a look at the overview table together. From left to right: This table provides an overview of upcoming and future pharmaceutical drugs for weight loss or metabolic disorders, categorized by year, company, drug name, and pharmaceutical formulation (oral or injection). Orforglipron (Eli Lilly) – Oral GLP‑1RA small molecule taken once daily Clinical results: Phase III ACHIEVE‑1 (type 2 diabetes): Lowered A1C by 1.3–1.6 pp and body weight by ~7.9% (~16 lb) at 40 weeks vs ~1.6% weight loss for placebo businessinsider.com+5 Oral Semaglutide – Novo Nordisk (“Rybelsus”) Novo Nordisk has submitted an application to the U.S. Food and Drug Administration (FDA) for oral semaglutide (a 25 mg once‑daily formulation of Wegovy) aimed at chronic weight management: ,based on encouraging Phase III OASIS‑4 data 25md oral Semaglutide is showing around 13.6 % mean weight loss at 64 weeks In May 2025, the FDA officially accepted the NDA and will decide in Q4 2025 Retatrutide (LY‑3437943) – Eli Lilly Mechanism: A triple agonist targeting GLP‑1, GIP, and glucagon receptors prnewswire.com+15 hase 2 (48 weeks): 8 mg dose → –22.8% body weight reduction 12 mg dose → –24.2% body weight reduction (~58 lb) Also reduced liver fat in patients with metabolic steatotic liver disease VK2735 – Viking Therapeutics (injectable + oral) Mechanism: Dual GLP‑1 and GIP receptor agonist (similar to tirzepatide) en.wikipedia.org. Formulations: Subcutaneous (weekly): Phase 2 data showed up to 14.7% weight loss in 13 weeks, with 88% of subjects achieving ≥10% weight loss pharmexec.com. Oral (daily): Phase 1 MAD study: Up to 8.2% weight loss over 28 day
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