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http://www.DoctorsToTrust.com @doctorstotrust presents episode 2606 | Dr BEN BIKMAN + expert panel Metabolic Health Summit Metabolic Health Summit panel Q&A… Ben Bikman: question on GLP1 drugs: in early research in low dose as anti-diabetic drug, had been lukewarm -primary mechanism of action: glucagon inhibition for one with hyperglycemia, this was a good way of bringing that down -at higher dose, primary mechanism of action is stomach paralysis [much less enthusiastic] One of the mechanism of improving insulin sensitivity from GLP1 drugs could be an induction of adipocyte hyperplasia [vs hypertrophy]. A sister version of the most popular one has been shown to activate hyperplasia [Liraglutide] How? You can be making new fat cells [hyperplasia] and still lose weight due to stomach paralysis… Concern about long term use of drug: substantial reduction of lean mass— again, due to stomach paralysis The day they want to get off of that drug…consider: middle age woman, lost both fat and lean mass on drug -also have increased number of fat cells -off drug: the fat mass will Easily return But, not all negative: If one can use lowest possible dose, and follow low carb diet--they can be fine |||||||||||||||||||||||||||||||| doctorstotrust.com metabolichealthsummit.com benbikman.com original video on here: https://youtu.be/J_AFik8DMoM?si=XHvwjwLJsYeG3o6g We do not use corruptible, epidemiological survey research as causal science. For each short/sharable video, the original Youtube links are provided above. None of this content is intended to be individual, personalized medical advice. We hope you find value for yourself in these videos & find them easy to share with loved ones! DISCLAIMER The DoctorsToTrust videos are for general informational purposes only and do not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the user’s own risk. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions.

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Loss of water weight was the main focus of weight loss with diuretics (similar to present-day water pills). The loss of water occurs via urination, leading to loss of salt but also essential minerals in the urine. Diuretics are not usually prescribed as a long-term therapy, and some people take them sporadically to shed weight. While water pills work for weight loss, do not underestimate the diuretic impact they have on a body, the risks or benefits associated with them.

The Mechanism of Action of Water Pills

​​They target different sites of the kidney to increase sodium excretion along the route it takes through the kidneys. This increases water excretion in proportion. Currently, there are three types of diuretics: thiazide diuretics, loop diuretics, and potassium-sparing diuretics. Thiazide diuretics target the site where potassium is reabsorbed along the distal tubules of the kidney, thereby promoting a bit more sodium and water excretion. Loop diuretics act on the loop of Henle in the kidney (a longer stretch where sodium is reabsorbed) and are much more effective at increasing urine production. Potassium-sparing diuretics target the collecting ducts in the kidney and retain potassium while promoting sodium and water excretion.

Over the course of the day, then, diuretics should cause the body to eliminate some fluid and thus some weight – although all that’s happening is that water and electrolytes are being shed, not fat.

Potential Side Effects of Water Pills

While water pills may help you lose water weight, they can also cause side effects. According to the US National Library of Medicine and National Institutes of Health, the most common side effects of diuretics include dehydration, electrolyte depletion (eg, low potassium), dizziness, thirst, and urination. More severe side effects of diuretics can include kidney damage, gout, and irregular heart rhythms.

This medication should be used under a doctor’s supervision and in the dose they instruct; prolonged diuretic use can result in dehydration and electrolyte disturbances, and higher doses can have other side-effects.

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Although water pills carry the risks we’ve discussed, they can be beneficial for some medical problems. Heart medicines known as diuretics are prescribed for high blood pressure, heart failure and fluid accumulation in the body (called oedema or fluid retention). By lowering the amount of fluid in one’s system, these pills can decrease blood pressure, reduce the oedema, and relieve the symptoms of heart failure.

Water pills can be a quick fix for those who want to shed some weight and feel lighter, especially for their wedding day by getting rid of the extra bloating and water weight. But, at the same time, if individuals want to shed weight healthily, water pills won’t lead to sustainable and healthy weight loss as any weight loss with a diuretic is just short-term and unnatural. Getting into a healthy weight and maintaining it requires sustainable healthy habits such as having a balanced diet and exercising regularly.

Considerations Before Using Water Pills for Weight Loss

Weight-loss pills meant to excrete more water should be taken with caution. While they might transport water out of the body, which could shed pounds temporarily, they are a route to nowhere. Nor should you start using pills like water pills diuretics without talking to your healthcare provider. These drugs help shed water, but that doesn’t make them magic beans for losing weight.

Also, watch for the possible (though rare) side effects of water pills. You will likely need to drink fluids and have your electrolytes checked while taking them. If you are concerned about any effects from the diuretics, including very bad dizziness, severe muscle cramps or spasms, or irregular heartbeats, contact your doctor right away.

Frequently Asked Questions about Water Pills

1. Can water pills help me lose fat?

No, the water weight lost with water pills is not fat loss and they don’t aid long-term weight management.

2. Are water pills safe for everyone to use?

Needless to say, we disagree strongly that any individual without medical guidance should be taking water pills. It might or might not work, and the issue of side effects and possible risks is significant. People with certain health issues may even find it dangerous to take water pills, and you won’t share this knowledge with them.

3. How long can I safely use water pills for weight loss?

Water pills are helpful for short term relief of water retention and bloating – don’t expect them to lead to long-term weight loss. Talk to your provider about how long you can take the pills.

4. Can I take a ‘magic’ water pill before to an event or occasion?

And although water pills can help with bloating, as well as temporary water weight, they should be used as short-term solutions only, and never overused or intensively. As long as people are happy with their healthy lifestyles, and they make smart choices to avoid junk food, they shouldn’t need these pills over extended periods of time.

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