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Incidence of Obesity & Type 2 diabetes is increasing more than ever! The current set of interventions are restricted to tracking blood sugar level using CGM, fad diets, high protein diets & pharmaceutical drugs.No wonder the therapeutic success is dismal! Now India is experiencing another wave of synthetic compound approach- GLP-1 receptor Agonists with a hope to control glycemic control, trigger weight loss & improve cardiovascular health. While at macro level this synthetic compound looks like a effective solution, if we dug deeper it may be starting point of metabolic disaster What exactly is GLP-1? GLP-1 is an incretin hormone naturally produced inside our body. Our gut microbiome could synthesise fibre, polyphenols & even N-oleoyl serinol in olive oil into GLP-1. This incretin hormone promotes satiety regulation, blood sugar control & even regulates heart health If the body is not able to produce GLP-1, then it is a biochemistry problem & the body is not at ease. Since there has been no tech that could measure GLP-1 levels( we the only company in India that can measure & quantify this incretin hormone), it is assumed that people suffering from obesity or type 2 diabetes suffer from GLP-1 deficiency. However no one actually measures specific inflammatory factors causing obesity. Is it really a GLP-1 deficiency? Or high P-cresol production? Low Butyrate Production? Elevated TMAO or high LPS? Until you know the source code for obesity how can you even prescribe interventions to address the disease. GLP-1 receptor Agonists may work for some people who actually have GLP-1 deficiency. However, the effectiveness of this drug depends upon: 1.Functions of your microbiome. Certain microbes can synthesise these drugs into beneficial stuff that have positive correlation with glycemic reduction while some others if active & expressing virulence genes can interfere with synthesis of GLP-1 drugs 2.Certain microbes if active & expressing virulence genes can degrade GLP-1, making you gain weight or develop type 2 diabetes. In such scenario, these drugs cannot help 3.GLP-1 drugs also activates endothelial nitric oxide synthase which could potentiate nitric oxide signalling that could dilate blood vessels, regulate glucose uptake & have anti-obesity impact. However for this to function, this enzyme should be coupled with endothelial cells. If it is uncoupled due to systemic inflammation or oxidative stress, it cannot trigger production of nitric oxide & these GLP-1 drugs will not work 4. These drugs act as an artificial break on your satiety paddle & slow down movement along your digestive tract & would cause constipation, bloating & other digestive troubles. 5. Even for people this drug works, they need to take this continuously as withdrawal from these drugs would lead to weight gain Citations https://diabetesjournals.org/care/article/33/2/453/27096/GLP-1-Based-Therapy-for-Diabetes-What-You-Do-Not https://pmc.ncbi.nlm.nih.gov/articles/PMC8793908/ https://pmc.ncbi.nlm.nih.gov/articles/PMC7021470/ https://pmc.ncbi.nlm.nih.gov/articles/PMC8833664/ https://dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/dom.14725 #glp1medication #glpromaxindonesia #glp1forweightloss #glp1weightloss #glpromax #weightloss #obesityepidemic #obesity #obesitymedicine #obesityprevention #obesitycontrol #obesityawareness