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A class of medications known as GLP-1 receptor agonists has revolutionized the treatment of type 2 diabetes and obesity. These drugs mimic the action of glucagon-like peptide-1 (GLP-1), a hormone that stimulates insulin secretion and inhibits glucagon release, helping to regulate blood sugar levels and promote weight loss. In this podcast, we’ll talk about the differences among some of the most well-known GLP-1 receptor agonists for type 2 diabetes.
Ozempic (Semaglutide)
Form: Injectable
Dosing Frequency: Once weekly
Uses: Primarily for type 2 diabetes (lower blood sugar and A1c); also approved for reducing the risk of major cardiovascular events like heart attack and stroke in adults with type 2 diabetes and known heart disease.
Keep in mind, Wegovy (semaglutide) is a higher-dose version that’s approved for weight loss. When you start taking Wegovy or Ozempic, you’ll begin with a low dosage. Your prescriber will increase your dosage every four weeks until you reach the target amount. However, the specific dosage you inject will differ depending on the medication. The maximum dose for Ozempic is 2mg weekly, while the target dose for Wegovy is 2.4mg weekly.
Rybelsus (Semaglutide) Form: Oral tablet
Dosing Frequency: Once daily
Uses: Lower blood sugar and A1c in people with type 2 diabetes.
Rybelsus shares the same active ingredient as the injectable medications Ozempic and Wegovy. Ozempic is also approved for Type 2 diabetes, while Wegovy is approved specifically for weight loss.
Rybelsus is available in three different strengths: 3 mg, 7 mg, and 14 mg. Similar to Ozempic, the dose is slowly increased every 4 weeks.
Good to know: It's important to take Rybelsus first thing in the morning with 4 oz of water. After taking it, you should wait at least 30 minutes before eating, drinking, or taking other medications. Failing to do so may reduce its effectiveness.
Currently, Rybelsus is undergoing clinical trials to evaluate its effectiveness for weight loss. The trials involve higher doses than those approved for diabetes treatment. Results indicate that a 50 mg dose of oral semaglutide (Rybelsus) achieves weight loss comparable to Wegovy.
Trulicity (Dulaglutide) Form: Injectable
Dosing Frequency: Once weekly
Uses: Type 2 diabetes; and like Ozempic, it’s also approved for reducing the risk of major cardiovascular events in adults with type 2 diabetes and established cardiovascular disease.
Like Ozempic and Rybelsus, you will start at a low dose to help reduce side effects. Your healthcare provider will then gradually increase the dose, balancing the management of side effects with the benefits of blood sugar control. The maximum dose for Trulicity is 4.5mg weekly.
Victoza (Liraglutide) Form: Injectable
Dosing Frequency: Once daily
Uses: Type 2 diabetes; also approved to reduce the risk of major cardiovascular events in adults with type 2 diabetes and established cardiovascular disease.
Victoza is one of three GLP-1 agonists approved for treating Type 2 diabetes in children aged 10 and older. The other options are Trulicity (dulaglutide) and Bydureon BCise (exenatide). More on this later. Ozempic, however, is only approved for use in adults.
Saxenda and Victoza are both injectable medications containing liraglutide, but they are approved for different uses. Saxenda is FDA-approved for chronic weight management in people 12 and older, while Victoza is approved for treating Type 2 diabetes in people 10 and older. Victoza also helps lower the risk of major adverse cardiovascular events in adults with diabetes and heart disease.
Both medications are injected once a day, starting with a low dose that is gradually increased over time. The target dose for Saxenda is 3 mg once daily, whereas the maximum dose for Victoza is 1.8 mg once daily.
Byetta (Exenatide) Form: Injectable
Dosing Frequency: Twice daily
Uses: Type 2 diabetes.
Additional Benefits: It has a shorter duration of action than other GLP-1 agonists, which may be preferable for some patients.
Byetta, approved in 2005, was the first GLP-1 medication of its kind for diabetes. Its active ingredient, exenatide, is a synthetic version of a substance found in Gila monster saliva.
The recommended starting dose for Byetta is 5 mcg twice daily, administered within 60 minutes before your morning and evening meals. After one month, your healthcare provider may increase the dose to 10 mcg twice daily. Starting at a lower dose helps reduce stomach-related side effects.
Bydureon BCise (Exenatide Extended-Release) Form: Injectable
Dosing Frequency: Once weekly
Uses: Type 2 diabetes.
Additional Benefits: Extended-release formulation provides a more convenient dosing schedule compared to Byetta.
Unlike Byetta, Bydureon BCise has a fixed dose of 2 mg administered once weekly, on the...
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A primary selling point of these weight loss pills is that they are made from natural ingredients that have been carefully determined to work synergistically to melt pounds away. But which ingredients could possibly make Alpilean work, and do these ingredients each actually have the weight loss properties they claim to have in Alpilean? Let’s take a look. The one inscription on its label that claims to single out Alpilean as a markedly effective weight-loss pill is the natural, or as they say, ‘purest’ ingredients it is made from. The ingredients that have been determined by Alpilean pill manufacturers to work synergistically for weight loss include green tea extract, garcinia cambogia and caffeine.
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Testimonials by actual customers could give us some clue on how Alpilean works. After all, if there is any product that customers leave positive comments for, it is health supplements. Especially if the product is as highly rated as this. Many people openly share their stories of Alpilean weight loss pills, including the best, most amazing, and even the complete opposite of what we desire. Some have reported great weight loss with Alpilean pills and magically increased energy levels, while others have seen no results at all.
Read Customer reviews with a critical eye, as sometimes; biased or sponsored reviews can be found. Sometimes, you will see reviews from ‘verified purchasers’ that can be helpful. Consider the general consensus of reviews to decide whether or not you would like to purchase Alpilean weight loss pills. Your results may vary depending on your overall health and lifestyle, so don’t expect same results as someone else within the same time frame or differently.
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Alpilean natural weight loss pills could be the solution you were looking for. Combining a variety of powerful ingredients and positive customer reviews, you could experience the weight loss solution you’re looking for, that is all-natural. However, you should be aware of the fact that weight loss outcomes and success can vary from person to person, and weight loss pills should be used in conjunction with a healthy diet and exercise routine. It’s important to consult your doctor before beginning any weight loss supplement to make sure you’re not taking something that is unsafe for you.
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Should you eat BREAKFAST? If so, what is the right time to eat? How much should you eat? Discussing the recommendation based on the circadian rhythm of hormones.
It is always better to skip dinner than skipping breakfast.
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Dr. Palaniappan Manickam MD, MPH
Internal Medicine | Gastroenterology | Epidemiologist
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