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The combined use of sodium-glucose transport protein 2 (SGLT2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists may offer notable benefits for optimizing cardiovascular and renal outcomes in patients with diabetes, according to recent research.
A collaborative meta-analysis of 12 trials from the SGLT2 Inhibitor Meta-Analysis Cardio-Renal Trialists’ Consortium (SMART-C) revealed consistent positive impacts on major adverse cardiovascular events, hospitalization for heart failure or cardiovascular death, chronic kidney disease progression, and the occurrence of adverse events with the combined use of SGLT2 inhibitors and GLP-1 receptor agonists.
“That information probably provides the strongest and clearest evidence yet that these drugs have independent and additive effects, and should be used in combination to further optimize cardiorenal prognosis,” Brendon Neuen, MBBS, PhD, said to HCPLive.
#Diabetes #ChronicKidneyDisease #HeartFailure #Cardiology #Nephrology
https://www.hcplive.com/view/brendon-neuen-mbbs-phd-optimizing-cardiorenal-prognosis--glp-1-sglt2-combination
https://www.hcplive.com/view/sglt2-inhibitor-glp-1-ra-combination-improves-cardiovascular-kidney-outcomes-diabetes
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