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Dr. Riccardo De Giorgi is a Clinical Lecturer at the University of Oxford’s Department of Psychiatry and a senior psychiatric trainee with Oxford Health NHS Foundation Trust. Dr. De Giorgi is deeply engaged in clinical practice and academic research, focusing on treatment-resistant mood disorders. His work explores the role of immunological and metabolic factors in mental illness and the potential for repurposing existing medications, such as statins and GLP1 receptor agonists, to treat patients who don't respond to conventional therapies. Overall, Dr. Riccardo is a passionate educator in the field of psychiatry who is always looking at these disorders from an embodied perspective where the mind is not separate from the body. Note: When discussing ways in which compounds may enter the brain, I used the term "circumventricular brain regions" when the most appropriate way to describe it is through "circumventricular organs (CVOs). This might be too pedantic, but in Science, terminology is very important. Dr. Riccardo's work and papers discussed: GLP-1 Paper: http://doi.org/10.1038/s44220-025-00390-x Statin Paper: DOI: 10.1016/j.jad.2022.05.113 Creatine Paper: http://doi.org/10.1016/j.euroneuro.2024.10.004 Follow Dr.Riccardo's work: https://x.com/rdegiorgi https://orcid.org/0000-0001-5984-8696 Chapters: 0:00 Intro 2:14 Dr.Riccardo's research 4:07 Treatment Resistance in Psychiatry 8:07 Anhedonia and Depression 9:16 Side effects of psychiatric medications 13:43 Ketogenic diet and metabolic interventions 18:20 Do we need to target the brain to heal it? 22:45 Blood-Brain barrier 25:29 GLP-1 RAs and Anhedonia 29:35 Statins & Depression 33:24 Creatine Monohydrate 35:25 Medication and Increased Suicidality 41:06 Stigma and Perceived Uniqueness of Psychiatry 46:03 Biggest Challenges in Psychiatry 49:48 Problems in Science 51:57 Science Denial 52:50 Tips for those struggling #glp1medication #mentalhealth #metabolichealth #ozempic #psychiatry #psychology
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