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Semaglutide is a medication that has recently gained popularity for its potential in aiding weight loss. Many people are interested in finding out the average weekly weight loss results that can be achieved while taking Semaglutide. In this article, we will explore the effectiveness of Semaglutide in promoting weight loss and discuss the average weekly weight loss that can be expected.

How Semaglutide Works

Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that works by mimicking the effects of the hormone GLP-1. This hormone helps regulate blood sugar levels, insulin secretion, and appetite. By activating the GLP-1 receptors in the body, Semaglutide can help reduce hunger and food intake, leading to weight loss.

Additionally, Semaglutide has been shown to slow down gastric emptying, which can help people feel full for a longer period after eating. This can further contribute to weight loss by reducing overall calorie intake. The medication is typically administered via subcutaneous injection once a week.





Studies have shown that Semaglutide can be an effective weight loss aid for individuals who are overweight or obese. In clinical trials, participants who took Semaglutide along with a reduced-calorie diet and increased physical activity experienced significant weight loss compared to those who followed the same diet and exercise regimen without the medication.

Average Weekly Weight Loss Expectations

The average weekly weight loss that can be achieved while taking Semaglutide varies from person to person. However, clinical trials have shown that individuals can expect to lose between 5-10% of their initial body weight within the first few months of treatment. This amounts to an average weight loss of 1-2 pounds per week.

It is important to note that the success of Semaglutide in promoting weight loss also depends on other factors such as diet and exercise habits, overall health, and individual metabolism. Some people may experience more significant weight loss results, while others may lose weight at a slower pace.

It is recommended to work closely with a healthcare provider while taking Semaglutide for weight loss. They can help monitor progress, adjust dosage as needed, and provide guidance on maintaining a healthy lifestyle to support weight loss goals.

Potential Side Effects

Like any medication, Semaglutide may cause side effects in some individuals. Common side effects of Semaglutide include nausea, vomiting, diarrhea, and constipation. These side effects are usually mild and temporary, but if they persist or worsen, it is important to consult a healthcare provider.

In rare cases, Semaglutide may also increase the risk of pancreatitis or thyroid tumors. It is important to be aware of these potential risks and discuss any concerns with a healthcare provider before starting treatment with Semaglutide. Overall, the benefits of weight loss achieved with Semaglutide may outweigh the potential risks for many individuals.

Overall, Semaglutide can be an effective weight loss aid for individuals looking to achieve their weight loss goals. By understanding how Semaglutide works, setting realistic expectations for average weekly weight loss, and being aware of potential side effects, individuals can make informed decisions about incorporating Semaglutide into their weight loss journey.

Conclusion

In conclusion, Semaglutide is a promising medication for promoting weight loss in individuals who are overweight or obese. With an average weekly weight loss of 1-2 pounds, Semaglutide can help individuals achieve significant weight loss results when combined with a healthy diet and regular exercise. While there are potential side effects to consider, the benefits of weight loss achieved with Semaglutide may outweigh the risks for many individuals. Consulting with a healthcare provider is essential to ensure safe and effective use of Semaglutide for weight loss goals.

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James Keys and Tunde Ogunlana consider whether American society needs GLP-1 drugs because of the way they work on people’s brains to help them eat less, particularly because the food industry in America apparently has gotten so good at formulating foods that work on people’s brains to make them addictive so people eat more. The guys also consider why so many people feel the need to hide their use of the drugs in light of how popular they are. https://www.nytimes.com/2025/05/07/opinion/ozempic-weight-loss-drugs.html https://www.theguardian.com/lifeandstyle/2025/may/11/weight-loss-drugs-why-do-people-lie-about-taking-ozempic

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Dr. Casey Means is a leading metabolic health expert and doctor from Stanford Medical School, NIH researcher, co-founder of health tech company Levels, and author of New York Times best-selling book Good Energy. She provides a science-based, nuanced perspective on the hot topics of Ozempic, weight loss, and the underlying metabolic crisis in America. Casey and Liz discuss the distinction between obesity and metabolic health, the influence of modern lifestyles on metabolic dysfunction, and the holistic approaches needed to improve metabolic health without relying solely on medications like Ozempic or Wegovy. The conversation also explores practical strategies to enhance mitochondrial function, such as dietary adjustments, movement vs. exercise, and reducing exposure to toxins. If you're looking to understand the science behind metabolic health and gain actionable insights to improve your well-being, this episode is a must-listen. LISTEN / SUBSCRIBE TO THE PODCAST Spotify: https://open.spotify.com/show/6dBAMh1qc4ML7xxbYwYwNj?si=3f255eb8b6c74b46 Apple: https://podcasts.apple.com/us/podcast/the-liz-moody-podcast/id1398442165 Youtube: https://www.youtube.com/@lizmoodypodcast 00:00 Intro 02:24 The Obesity and Metabolic Health Debate 04:57 Understanding Different Types of Fat: Subcutaneous, Visceral, and Intracellular 06:36 Ozempic's Impact on Metabolic Health 07:56 Mitochondria and Metabolic Health 08:32 The Eight Pillars Affecting Mitochondria 12:00 Ozempic: Mechanisms and Physical Effects 26:24 Natural Ways to Boost GLP-1 and Inhibit DPP-4 30:22 The Food Industry and Cravings 37:42 The Consequences of Obesity and the Healthcare System 38:50 Personal Responsibility vs. Systemic Forces 39:43 The Impact of Policy on Health 40:53 Understanding Metabolic Health 45:09 Tracking Biomarkers for Better Health 47:34 Addressing Hidden Health Issues 58:11 The Importance of Movement vs Exercise 59:57 The Dangers of Ultra-Processed Foods 64:21 The Root Cause of Health Issues If you’re new here, I’m Liz Moody! I’m a longtime journalist, thought leader, and best-selling author. I host The Liz Moody Podcast where every week, we’re sharing real science, real stories, and realistic tools that ACTUALLY level up every part of your life. If you want to know more, visit my website or check me out on The TODAY Show with Hoda Kotb and Jenna Bush Hager: https://www.lizmoody.com https://youtu.be/pIE6JJ50CNM?si=-wnv2zF9ft9fqWZw CONNECT WITH ME Instagram: https://www.instagram.com/lizmoody/ Tiktok: https://www.tiktok.com/@lizmoody Order my book 100 Ways to Change Your Life: The Science of Leveling Up Health, Happiness, Relationships & Success: https://www.100waystochangeyourlife.com Newsletter: https://www.lizmoody.com Liz Moody Podcast Club Facebook Group: https://www.facebook.com/groups/thelizmoodypodcast CONNECT WITH DR. CASEY MEANS Website: https://www.caseymeans.com Order her book Good Energy: The Surprising Connection Between Metabolism and Limitless Health: https://www.caseymeans.com/goodenergy Instagram: https://www.instagram.com/drcaseyskitchen/ Youtube: https://www.youtube.com/channel/UCsxX_iM425PEU5VjNCZQ37g Linkedin: https://www.linkedin.com/in/casey-means-md This podcast and website represents the opinions of Liz Moody and her guests to the show. The content here should not be taken as medical advice. The content here is for information purposes only, and because each person is so unique, please consult your healthcare professional for any medical questions. The Liz Moody Podcast Episode 250. #lizmoody #lizmoodypodcast #science #health #nutrition #weightloss